The present invention discloses synthetic oligonucleotides complementary to a nucleic acid spanning the translational start site of human papillomavirus gene E1, and including at least 15 nucleotides. Also disclosed are methods and kits for inhibiting the replication of HPV, for inhibiting the expre
The present invention discloses synthetic oligonucleotides complementary to a nucleic acid spanning the translational start site of human papillomavirus gene E1, and including at least 15 nucleotides. Also disclosed are methods and kits for inhibiting the replication of HPV, for inhibiting the expression of HPV nucleic acid and protein, for detection of HPV, and for treating HPV infections.
대표청구항▼
The present invention discloses synthetic oligonucleotides complementary to a nucleic acid spanning the translational start site of human papillomavirus gene E1, and including at least 15 nucleotides. Also disclosed are methods and kits for inhibiting the replication of HPV, for inhibiting the expre
The present invention discloses synthetic oligonucleotides complementary to a nucleic acid spanning the translational start site of human papillomavirus gene E1, and including at least 15 nucleotides. Also disclosed are methods and kits for inhibiting the replication of HPV, for inhibiting the expression of HPV nucleic acid and protein, for detection of HPV, and for treating HPV infections. UB>and Ar= can be linked to form a 5- to 8-membered ring; Ar'=aryl group; and R=a hydrogen atom or an unsubstituted or substituted alkyl group. 7. A photographic element according to claim 6, wherein X is selected from: R=a hydrogen atom or an unsubstituted or substituted alkyl group. 8. A photographic element according to claim 1, wherein X is of structure (IV): wherein: "ring" represents a substituted or unsubstituted 5-, 6- or 7-membered unsaturated ring. 9. A photographic element according to claim 8, wherein X is selected from: Z3=O, S, Se, or NR; R15=R, OR, or NR2; R16=alkyl, substituted alkyl; and R=a hydrogen atom or an unsubstituted or substituted alkyl group. 10. A photographic element according to claim 1, wherein Y' is selected from (1) through (5): (1) X', where X' is an X group as defined in structures I-IV and may be the same as or different from the X group to which it is attached; where M=Si, Sn or Ge; and R'=alkyl or substituted alkyl where Ar"=aryl or substituted aryl wherein structures I-IV are as follows: R1=R, carboxyl, amide, sulfonamide, halogen, NR2,(OH)n,(OR')n,or (SR)n; R'=alkyl or substituted alkyl; n=1-3; R2=R, or Ar'; R3=R, or Ar'; R2and R3together can form a 5- to 8-membered ring: Ar=aryl group; m=0, 1; Z=O, S, Se, or Te; R2and Ar= can be linked to form a 5- to 8-membered ring; R3and Ar= can be linked to form a 5- to 8-membered ring; Ar'=aryl group, or heterocyclic group; and R=a hydrogen atom or an unsubstituted or substituted alkyl group; wherein: Ar=aryl group; R4=a substituent having a Hammett sigma value of -1 to +1; R5=R, or Ar'; R6=R, Ar'or, if R6is linked to Ar, R6can be a hetero atom; R7=R, or Ar'; R5and Ar= can be linked to form a 5- to 8-membered ring; R6and Ar= can be linked to form a 5- to 8-membered ring; R5and R6can be linked to form a 5- to 8-membered ring; R6and R7can be linked to form a 5- to 8-membered ring; Ar'=aryl group; and R=hydrogen atom or an unsubstituted or substituted alkyl group; wherein: W=O, S, or Se; Ar=aryl group or heterocyclic group; R8=R, carboxyl, NR2,(OR)n,or (SR)n(n=1-3); R9and R10=R, or Ar'; R9and Ar= can be linked to form a 5- to 8-membered ring; Ar'=aryl group; and R=a hydrogen atom or an unsubstituted or substituted alkyl group; wherein: "ring" represents a substituted or unsubstituted 5-, 6- or 7-membered unsaturated ring. 11. A photographic element according to claim 1, wherein the fragmentable electron donor compound is selected from the group consisting of: 12. A photographic element according to claim 1, wherein the dye providing a peak sensitization between 446 and 500 nm is of formula (VII) wherein: Z13and Z14,independently represent the atoms necessary to complete a substituted or unsubstituted benzene or naphthylene; X11and Y11are independently O, S, Se or NR25,wherein R25is an alkyl, alkenyl, aryl, any of which may be substituted or unsubstituted; R23and R24independently represent and alkyl, alkenyl or aryl, any or which may be substituted or unsubstituted. 13. A photographic element according to claim 1, wherein the dye providing a peak sensitization between 400 and 445 nm is of structure (VI): wherein: Z11and Z12independently represent the atoms necessary to complete a substituted or unsubstituted benzene or naphthylene; X10and Y10,are independently O, S, Se or NR25,provided that at least X10or Y10is O o
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이 특허에 인용된 특허 (17)
Bhatnagar Satish K. (Gaithersburg MD) George ; Jr. Albert L. (Gaithersburg MD) Nazarenko Irina (Gaithersburg MD), Amplification of nucleic acid sequences.
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