Metered dose inhaler for beclomethasone dipropionate
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IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/12
A61K-009/72
출원번호
US-0506838
(2000-02-18)
발명자
/ 주소
Britto, Ignatius Loy
Ashurst, Ian Car
Herman, Craig Steven
Li-Bovet, Li
Riebe, Michael Thomas
출원인 / 주소
SmithKline Beecham Corp.
대리인 / 주소
Birch, Stewart, Kolasch & Birch, LLP
인용정보
피인용 횟수 :
3인용 특허 :
61
초록▼
A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising beclomethasone dipropionate or a physiologically acceptable
A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising beclomethasone dipropionate or a physiologically acceptable solvate thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients.
대표청구항▼
A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising beclomethasone dipropionate or a physiologically acceptable
A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising beclomethasone dipropionate or a physiologically acceptable solvate thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients. SUB>NR10eR11e,OR10e,and N(R11e)R12e; Ueis selected from: --(CH2)ne--, --(CH2)neO(CH2)me--, --(CH2)neN(R12) (CH2)me--, --NH(CH2)ne--,--(CH2)neC(=O)(CH2)me--, --(CH2)neS(O)pe(CH2)me--, --(CH2)neNHNH(CH2)me--, --N(R10e)C(=O)--, --NHC(=O)(CH2)ne--, --C(=O)N(R10e)--, and --N(R10e)S(O)pe; Geis N or CR19e; Weis --C(=O)--N(R10e)--(C1-C3alkylene)--, in which the alkylene group is substituted by R8eand by R9e: R8eand R9eare independently selected from: H, CO2R18be,C(=O)R18be,CONR17R18be, C1-C10alkyl substituted with 0-1 R6e, C2-C10alkenyl substituted with 0-1 R6e, C2-C10alkynyl substituted with 0-1 R6e, C3-C8cycloalkyl substituted with 0-1 R6e, C5-C6cycloalkenyl substituted with 0-1 R6e, (C1-C10alkyl) carbonyl, C3-C10cycloalkyl(C1-C4alkyl)--, phenyl substituted with 0-3 R6e, naphthyl substituted with 0-3 R6e, a 5-10 membered heterocyclic ring containing 1-3 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-2 R7e, C1-C10alkoxy substituted with 0-2 R7e, hydroxy, nitro, --N(R10e)R11e,--N(R16e)R17e,aryl(C0-C6alkyl)carbonyl, aryl (C3-C6alkyl), heteroaryl (C1-C6alkyl), CONR18aeR20e,SO2R18ae,and SO2NR18aeR20e, providing that any of the above alkyl, cycloalkyl, aryl or heteroaryl groups may be unsubstituted or substituted independently with 1-2 R7e; R6eis selected from: H, C1-C10alkyl, hydroxy, C1-C10alkoxy, nitro, C1-C10alkylcarbonyl, --N(R11e)R12e,cyano, halo, CF3,CHO, CO2R18be,C(=O)R18be,CONR17eR18be,OC(=O)R10e,OR10e,OC(=O)NR10eR11e,NR10eC(=O)R10e,NR10eC(=O)OR21e,NR10eC(=O)NR10eR11e,NR10eSO2NR10eR11e,NR10eSO2R21e,S(O)pR11e,SO2NR10eR11e, aryl substituted with 0-3 groups selected from halogen, C1-C6alkoxy, C1-C6alkyl, CF3,S(O)meMe, and --NMe2, aryl(C1-C4alkyl)--, said aryl being substituted with 0-3 groups selected from halogen, C1-C6alkoxy, C1-C6alkyl, CF3,S(O)peMe, and --NMe2,and a 5-10 membered heterocyclic ring containing 1-3 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substit
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