초록 ▼

Novel compounds and compositions for modulating NMDA receptor function comprising Conantokin-G and derivatives thereof; methods for modulating NMDA receptor function and methods for treating neuropsychopharmacological disorders, using the novel compounds and compositions of the invention; and a meth

Novel compounds and compositions for modulating NMDA receptor function comprising Conantokin-G and derivatives thereof; methods for modulating NMDA receptor function and methods for treating neuropsychopharmacological disorders, using the novel compounds and compositions of the invention; and a method for screening compounds capable of binding to a novel allosteric modulatory site, are described.

대표청구항 ▼

Novel compounds and compositions for modulating NMDA receptor function comprising Conantokin-G and derivatives thereof; methods for modulating NMDA receptor function and methods for treating neuropsychopharmacological disorders, using the novel compounds and compositions of the invention; and a meth

Novel compounds and compositions for modulating NMDA receptor function comprising Conantokin-G and derivatives thereof; methods for modulating NMDA receptor function and methods for treating neuropsychopharmacological disorders, using the novel compounds and compositions of the invention; and a method for screening compounds capable of binding to a novel allosteric modulatory site, are described. 973). McDevitt et al., Clin. Orthoped., 252:8-18 (1990). Nehrer et al., "Autologous Chondrocyte-Seeded Type I and II Collagen Matrices Implanted in a Chondral Defect in a Canine Model" 44th Annual Meeting, Orthopaedic Research Society, Mar. 16-19, 1998, New Orleans, Louisiana. Riesle et al., J. Cell Biochem., 71(3):313-327 (1998). Sellers et al., J. of Bone and Joint Surg., 79-A(10):1452-1463 (1997). Sonoda et al., "Characterization of Tissue Healing Following Meniscal Injury and Repair: The Effect of Hyaluronan Treatment" 44th Annual Meeting, Orthopaedic Research Society, Mar. 16-19, 1998, New Orleans, Louisiana. Spilker et al., J. Biomech., 25(9):1027-1045 (1992). Stone et al., J. of Bone and Joint Surg., 79-A(12):1770-1777 (1997). Stone et al., "Surgical Technique of Meniscal Replacement," Technical Note, The Stone Clinic. Temple et al., "Effect of Meniscal Repair and Hyaluronan Treatment on Cartilage Degeneration of the Femur and Tibia in the Rabbit" 45th Annual Meeting, Orthopaedic Research Society, Feb. 1-4, 1999, Anaheim, California.