Synergistic compositions for lycopene and Vitamin E for the prevention of LDL oxidation
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/355
A61K-035/78
출원번호
US-0446241
(2000-04-03)
우선권정보
IL-121112 (1997-06-19)
국제출원번호
PCT/IL98/00286
(1998-06-18)
국제공개번호
WO98/57622
(1998-12-23)
발명자
/ 주소
Fuhrman, Bianca
Aviram, Michael
Nir, Zohar
Zelkha, Morris
출원인 / 주소
Lycored Natural Products Industries Ltd.
대리인 / 주소
Browdy and Neimark
인용정보
피인용 횟수 :
7인용 특허 :
2
초록
A synergistic mixture containing lycopene and Vitamin E and its use in the prevention of LDL oxidation. Lycopene is either synthetic or from natural sources. Furthermore the preparation of a pharmaceutical and a dietary composition for arresting the progression of atheroclerosis is described.
대표청구항▼
1. A synergistic pharmaceutical or dietary composition which comprises synergistic effective amounts of lycopene and vitamin E. 2. A composition in accordance with claim 1 wherein the lycopene is selected from the group consisting of lycopene from tomato oleoresin, algal, fermented, fungal, genetica
1. A synergistic pharmaceutical or dietary composition which comprises synergistic effective amounts of lycopene and vitamin E. 2. A composition in accordance with claim 1 wherein the lycopene is selected from the group consisting of lycopene from tomato oleoresin, algal, fermented, fungal, genetically modified organisms (GMO), synthetic lycopene and mixtures thereof. 3. A composition in accordance with claim 1 wherein the concentration of vitamin E is in the range of 0.025 μM to 50 μM. 4. A composition in accordance with claim 1 wherein the concentration of lycopene is in the range of 0.025 μM to 50 μM. 5. A composition in accordance with claim 3 wherein the molar ratio of lycopene to vitamin E is 1:400 to 10:1. 6. A composition in accordance with claim 1 wherein the composition contains a compound selected from the group consisting of dietary components, additives, excipients, binding agents, coatings, preservatives and mixtures thereof. 7. A composition in accordance with claim 1 wherein the lycopene and vitamin E mixture is contained in a dosage form selected from the group consisting of tablets, caplets, vegecaps and hard shell gelatin capsules. 8. A method for arresting the progression of atherosclerosis comprising synergistic effective amounts of administering to a subject in need thereof a synergistic composition containing lycopene and vitamin E. 9. A method in accordance with claim 8 wherein the lycopene is selected from the group consisting of lycopene from tomato, algal, fermented, fungal, genetically modified organisms (GMO), synthetic lycopene and mixtures thereof. 10. A method in accordance with claim 8 wherein the vitamin E concentration is in the range of 0.025 μM to 50 μM. 11. A method in accordance with claim 8 wherein the concentration of lycopene is in the range of 0.025 μM to 50 μM. 12. A method in accordance with claim 8 wherein the molar ratio of lycopene to vitamin E is 1:400 to 10:1. 13. A method in accordance with claim 8 wherein the composition contains a compound selected from the group consisting of dietary components, additives, excipients, binding agents, coatings, preservatives and mixtures thereof. 14. A method in accordance with claim 8 wherein the lycopene and vitamin E mixture is contained in a dosage form selected from the group consisting of tablets, caplets, vegecaps and hard shell gelatin capsules. 15. A method for blocking the oxidation of LDL in serum which comprises synergistic effective amounts of contacting the serum with a synergistic composition which comprises lycopene and vitamin E. 16. A method in accordance with claim 15 wherein the lycopene is selected from the group consisting of lycopene from tomato, algal, fermented, fungal, genetically modified organisms (GMO), synthetic lycopene and mixtures thereof. 17. A method in accordance with claim 15 wherein vitamin E concentration is in the range of 0.025 μM to 50 μM. 18. A method in accordance with claim 15 wherein the concentration of lycopene is in the range of 0.025 μM to 50 μM and most 0.5 μM. 19. A method in accordance with claim 17 wherein the molar ratio of lycopene to vitamin E is 1:400 to 10:1. 20. A method in accordance with claim 15 wherein the composition contains a compound selected from the group consisting of dietary components, additives, excipients, binding agents, coatings, preservatives, and mixtures thereof. 21. A method in accordance with claim 15 wherein the lycopene and vitamin E mixture is contained in a dosage form selected from the group consisting of tablets, caplets, vegecaps and hard shell gelatin capsules. 22. The method of claim 8 wherein the vitamin E concentration is 0.5 μM to 5 μM, the concentration of lycopene is 0.5 μM to 10 μM, and the molar ratio of lycopene to vitamin E is 1:80 to 5:1.
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이 특허에 인용된 특허 (2)
Hennekens Charles H., Beta-carotene vitamin E therapy for inhibition of major vascular events.
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