IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
|
출원번호 |
US-0991182
(1992-12-10)
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발명자
/ 주소 |
- Wong, Chi-Huey
- Kondo, Hirosato
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출원인 / 주소 |
- The Scripps Research Institute
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대리인 / 주소 |
Lewis, Donald G.Fitting, Thomas
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인용정보 |
피인용 횟수 :
0 인용 특허 :
6 |
초록
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Phosphite linked nucleotide sugars, e.g. nucleoside-monophosphite-glycosides, are synthesized using phosphoramiditing agents. The success of the synthetic method is largely independent of the choice of sugar and of nucleotide. The phosphite linked nucleotide sugars are shown to be useful, in the pre
Phosphite linked nucleotide sugars, e.g. nucleoside-monophosphite-glycosides, are synthesized using phosphoramiditing agents. The success of the synthetic method is largely independent of the choice of sugar and of nucleotide. The phosphite linked nucleotide sugars are shown to be useful, in the presence of an oxidizing agent, for the production of phosphate linked nucleotide sugars, e.g. nucleoside-monophosphate-glycosides.
대표청구항
▼
Phosphite linked nucleotide sugars, e.g. nucleoside-monophosphite-glycosides, are synthesized using phosphoramiditing agents. The success of the synthetic method is largely independent of the choice of sugar and of nucleotide. The phosphite linked nucleotide sugars are shown to be useful, in the pre
Phosphite linked nucleotide sugars, e.g. nucleoside-monophosphite-glycosides, are synthesized using phosphoramiditing agents. The success of the synthetic method is largely independent of the choice of sugar and of nucleotide. The phosphite linked nucleotide sugars are shown to be useful, in the presence of an oxidizing agent, for the production of phosphate linked nucleotide sugars, e.g. nucleoside-monophosphate-glycosides. in Human Neutrophils," Journal of Pharmaceutical Pharmacology, 49(5), 562-566 (May, 1997). Kim et al., "Structural Identification of Glycerolipid Molecular Species Isolated from Cyanobacterium Synechocytis sp. PCC 6803 Using Fast Atom Bombardment Tandem Mass Spectrometry," Analytical Biochemistry, 267, 260-270 (1999). Yoshiyuki Mizushina, Shonen Yoshida, Akio Matsukage and Kengo Sakaguchi, "The Inhibiting Action of Fatty Acids on DNA Polymerase β", Biochemica et Biophysica Acta, 1336, (1997), 509-521. Keisuke Ohta et al., "Sulfoquinovosyldiacylglycerol, KMO43, a New Potent Inhibitor of Eukaryctic DNA Polymerases and HIV-Reverse Transcriptase Type 1 from a Marine Red Alga, Gigartina tenella", Chem. Pharm. Bull., 46(4), 684-696 (1998). Yoshiyuki Mizushina et al., "Studies on Inhibitors of Mammalian DNA Polymerase αand β", Biochemical Pharmacology, 55, 537-541 (1998). H. Sahra et al., "In vivo anti-tumour effect of 3'-sulphonoquinovosyl 1'-monoacylglyceride isolated from sea urchin (Strongylocentrotus intermedius) intestine", British Journal of Cancer, 75(3), 324-332 (1997). Dan M. Gordon et al., "Synthesis of a Cyanobacterial Sulfolipid: Confirmation if Its Structure, Stereochemistry, and Anti-HIV-1 Activity", J. Amer. Chem. Soc., 114, 659-663 (1992). Roy Gigg et al., "Synthesis of 3-O-(6-Deoxy-6-sulpho-α-D-glucopyranosyl)-1, 2-di-O-hexadecanoyl-L-glycerol, Sulphoquinovosyl Diglyceride", Journal of the Chemical Society Perkin Transaction I, 2490-2493 (1980). Hideaki Shirahashi et al., "Isolation and Identification of Anti-tumor-Promoting Principles from the Fresh-Water Cyanobacterium Phormidium tenue", Chem. Pharm. Bull., 41(9), 1664-1666 (1993). *Pharm Quang Lien et al., "Structures, teneurs et compositions des esters sulfuriques, sulfoniques, phosphoriques des glycosyldiglcerides de trois fucasees", Biochimie, 58, 1367-1380 (1976). Michael Keusgen et al., "Sulfoquinovosyl Diacylglycerols from the Alga Heterosigma carterae", Lipids, 1101-1112, 32, (1997). Byeng Wha Son, "Glycolipids from Gracilaria Verrucosa", Pyhtochemistry, 29, 307-309 (1990). Luca Rastrelli, "Glycolipids from Byrsonima Crassifolia", Phytochemistry, 45, 647-650 (1997).
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