Thermally-activated microchip chemical delivery devices
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/11
A61M-037/00
출원번호
US-0638109
(2000-08-11)
발명자
/ 주소
Santini, Jr., John T.
Cima, Michael J.
Uhland, Scott Albert
출원인 / 주소
MicroCHIPS, Inc.
대리인 / 주소
Sutherland Asbill & Brennan LLP
인용정보
피인용 횟수 :
109인용 특허 :
38
초록▼
Microchip delivery devices are provided that control both the rate and time of release of molecules, wherein the device includes a substrate, at least one reservoir in the substrate containing the molecules, and a reservoir cap positioned on the reservoir over the molecules, wherein the molecules ar
Microchip delivery devices are provided that control both the rate and time of release of molecules, wherein the device includes a substrate, at least one reservoir in the substrate containing the molecules, and a reservoir cap positioned on the reservoir over the molecules, wherein the molecules are released from the reservoir upon heating or cooling the device or a portion thereof sufficient to rupture the reservoir cap. In a preferred embodiment, the device includes a resistor integrated into the reservoir or mounted near the reservoir, which upon application of an electric current through the resistor, causes at least one of the contents of the reservoir to thermally expand, vaporize, phase change, or undergo a thermally driven reaction, such that the reservoir cap ruptures due to mechanical stress. In another preferred embodiment, application of an electric current to a resistor located on or near the reservoir cap causes the cap to expand, contract, or undergo a phase change that results in the rupture of the reservoir cap. The reservoirs can contain multiple drugs or other molecules in variable dosages. Each of the reservoirs of a single microchip can contain different molecules and/or different amounts and concentrations, which can be released independently.
대표청구항▼
Microchip delivery devices are provided that control both the rate and time of release of molecules, wherein the device includes a substrate, at least one reservoir in the substrate containing the molecules, and a reservoir cap positioned on the reservoir over the molecules, wherein the molecules ar
Microchip delivery devices are provided that control both the rate and time of release of molecules, wherein the device includes a substrate, at least one reservoir in the substrate containing the molecules, and a reservoir cap positioned on the reservoir over the molecules, wherein the molecules are released from the reservoir upon heating or cooling the device or a portion thereof sufficient to rupture the reservoir cap. In a preferred embodiment, the device includes a resistor integrated into the reservoir or mounted near the reservoir, which upon application of an electric current through the resistor, causes at least one of the contents of the reservoir to thermally expand, vaporize, phase change, or undergo a thermally driven reaction, such that the reservoir cap ruptures due to mechanical stress. In another preferred embodiment, application of an electric current to a resistor located on or near the reservoir cap causes the cap to expand, contract, or undergo a phase change that results in the rupture of the reservoir cap. The reservoirs can contain multiple drugs or other molecules in variable dosages. Each of the reservoirs of a single microchip can contain different molecules and/or different amounts and concentrations, which can be released independently. ng a stored health profile of a previously registered user with a current health profile received from a personal health monitoring system associated with said previously registered user. 4. The method for auditing public health according to claim 1, said step of compiling a plurality of health profiles from a plurality of personal health monitoring systems, further comprising the step of: compiling said plurality of health profiles from said plurality of personal health monitoring systems associated with a plurality of employees of a company. 5. The method for auditing public health according to claim 1, said step of compiling a plurality of health profiles from a plurality of personal health monitoring systems, further comprising the step of: compiling said plurality of health profiles from said plurality of personal health monitoring systems associated with a plurality of participants in an experiment. 6. The method for auditing public health according to claim 1, said method further comprising the step of: performing statistical analysis on percentages of said plurality of health profiles including said particular health affecting factor. 7. The method for auditing public health according to claim 1, said method further comprising the step of: analyzing said plurality of health profiles in view of selected health affecting factors to determine which users are affected. 8. The method for auditing public health according to claim 1, said method further comprising the step of: providing incentives to meet certain health requirements to those users associated with said percentage of said plurality of health profiles that are acceptable in view of said model health profile. 9. A system for auditing public health, said system comprising: means for compiling a plurality of health profiles from a plurality of personal health monitoring systems each respectively monitoring a current health profile including physical parameters and environmental parameters indicative of the current health of one of a plurality of users; means for comparing said physical parameters and said environmental parameters of each of said plurality of health profiles to determine health affecting factors for said plurality of users, such that health affecting factors of public health are audited; means for comparing said plurality of health profiles with a model health profile; means for determining a percentage of said plurality of health profiles that are acceptable in view of sai
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