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Method for transferring nucleic acid into multicelled eukaryotic organism cells and combination therefor 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12N-015/87
  • C12Q-001/68
  • C12P-019/34
  • C07H-021/02
  • C07H-021/04
출원번호 US-0446690 (2000-02-02)
우선권정보 FR-0008232 (1997-06-30)
국제출원번호 PCT/FR98/01399 (1998-06-30)
국제공개번호 WO99/01157 (1999-01-14)
발명자 / 주소
  • Bureau, Michel
  • Mir, Lluis
  • Scherman, Daniel
출원인 / 주소
  • Aventis Pharma S.A.
대리인 / 주소
    Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
인용정보 피인용 횟수 : 6  인용 특허 : 57

초록 ▼

The invention concerns an improved method for transferring in vivo multicelled eukaryotic organism cells nucleic acids or nucleic acids combined with products for enhancing the efficacy of such transfers. The invention also concerns the combination of a nucleic acid and the transfer method for use i

대표청구항 ▼

The invention concerns an improved method for transferring in vivo multicelled eukaryotic organism cells nucleic acids or nucleic acids combined with products for enhancing the efficacy of such transfers. The invention also concerns the combination of a nucleic acid and the transfer method for use i

이 특허에 인용된 특허 (57)

  1. Hofmann Gunter A. ; Dev Sukhendu B. ; Dimmer Steven C. ; Levatter Jeffrey I. ; Nanda Gurvinder S., Apparatus for addressing needle array electrodes for electroporation therapy.
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  4. Hofmann Gunter A. (San Diego CA), Apparatus for fusing live cells with electric fields.
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  5. Hofmann Gunter A. (San Diego CA), Applicator for the electroporation of drugs and genes into surface cells.
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  6. Sibalis, Dan, Applicator for the non-invasive transcutaneous delivery of medicament.
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  7. Deletis Vedran (Edison NJ), Catheter for spinal epidural injection of drugs and measurement of evoked potentials.
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  8. Matschke Christain (Alsdorf DEX) Arnold William M. (Jlich DEX) Bchner Karl-Heinz (Jlich DEX) Zimmerman Ulrich (Hrtgenwald-Gey DEX), Chamber for the treatment of cells in an electrical field.
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  9. Hale Ron L. (Woodside CA) Lu Amy (Los Altos CA) Solas Dennis (San Francisco CA) Selick Harold E. (Belmont CA) Oldenburg Kevin R. (Fremont CA) Zaffaroni Alejandro C. (Atherton CA), Compositions and methods for enhanced drug delivery.
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  10. Oldenburg Kevin R. ; Selick Harold E., Compounds with PTH activity.
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  11. Weaver James C. (Sudbury MA) Powell Kevin T. (Boston MA) Langer ; Jr. Robert S. (Newton MA), Control of transport of molecules across tissue using electroporation.
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  12. Zewert Thomas E. ; Pliquett Uwe ; Langer Robert S. ; Weaver James C., Delivery of nucleotides into organisms by electroporation.
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  13. Shapland James E. (Shoreview MN) Knudson Mark B. (Shoreview MN) Shimada Jin (Falcon Heights MN), Drug delivery apparatus and method.
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  14. Shapland James E. (Shoreview MN) Knudson Mark B. (Shoreview MN) Shimada Jin (Falcon Heights MN) Hildebrand Keith R. (Houlton WI), Drug delivery apparatus and method.
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  15. Mir Lluis (Verrieres-le-Buisson FRX) Orlowski Stephane (Bourg-la-Reine FRX) Siros Michel (Antony FRX), Electric pulse applicator using pairs of needle electrodes for the treatment of biological tissue.
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  16. Mir Lluis (Verrires le Buisson FRX), Electrochemotherapy.
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  17. Powers Whitney R. (Topsfield MA) Sisun Henry (Pawtucket RI), Electrodes, electrode assemblies, methods, and systems for tissue stimulation.
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  18. Powers Whitney R. (Topsfield MA) Sisun Henry (Pawtucket RI), Electrodes, electrode assemblies, methods, and systems for tissue stimulation and transdermal delivery of pharmacologica.
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  19. Hofmann Gunter A. (San Diego CA) Zhang Lei (San Diego CA), Electronincorporation enhanced transdermal delivery of molecules.
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  20. Baer Bradford W. (420 Claremont Way Menlo Park CA 94025), Electroporation apparatus and process.
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  21. Crandell Lois J. (San Diego CA) Hofmann Gunter A. (San Diego CA), Electroporation method and apparatus for insertion of drugs and genes into endothelial cells.
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  22. Hofmann Gunter A., Electroporation system with voltage control feedback for clinical applications.
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  23. Hofmann Gunter A. (San Diego CA), Electroporation system with voltage control feedback for clinical applications.
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  24. Hofmann Gunter A. ; Dev Sukhendu B. ; Dimmer Steven C. ; Levatter Jeffrey I. ; Nanda Gurvinder S., Electroporation therapy apparatus.
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  25. Dev Sukhendu B. ; Dev Nagendu B. ; Hofmann Gunter A., Electroporation-mediated intravascular delivery.
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  26. Murry Lynn E. (Portola Valley CA) Sinibaldi Ralph M. (Fremont CA) Dietrich Paul S. (Palo Alto CA) Alfinito Sharon C. H. (Fremont CA), Electrotransformation process.
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  27. Xavier Ravi (732 Ibis Way N. Palm Beach FL 33408), Epidural catheter with nerve stimulators.
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  28. Helmbrecht Peter (Esslingen DEX) Fehlmann Wolfgang (Stuttgart DEX) Schultheiss Gerold (Pforzheim DEX) Junger Dieter (Stuttgart DEX) Kebrich Bodo (Merzweiler DEX) Morel-Fourrier J. Paul (Valencin FRX), Fuel-injection pump.
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  29. Wong Daniel T. (18866 Allendale Ave. Saratoga CA 95070) Wong Tai-Kin (18641 Crabtree Ave. Cupertino CA 95014), High-voltage biological macromolecule transfer and cell fusion system.
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  30. Galindo Anibal (6500 Caballero Blvd. Coral Gables FL 33146), Hypodermic needle.
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  31. Rizk Nabil I. (229 Haymont Dr. Gibsonia PA 15044) Stevens Charles L. (Pittsburgh PA), Implantable electrophoretic pump for ionic drugs and associated methods.
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  32. Hofmann Gunter A. (San Diego CA), Implantable electroporation method and apparatus for drug and gene delivery.
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  33. Sibalis Dan (Stony Brook NY), Indicator for electrophoretic transcutaneous drug delivery device.
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  34. Hofmann Gunter A. (San Diego CA), Injection and electroporation apparatus for drug and gene delivery.
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  35. Kee Douglas P.,CAX ; Russell Douglas M.,CAX ; Hicton Raymond L.,CAX, Intermodal bulk container.
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  36. Ariura Shunsuke (Matsudo JPX) Ogata Tadashi (Fuchu JPX) Kashima Norie (Tokyo JPX) Morihata Michiyo (Fuchu JPX), Iontophoresis device.
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  37. Weaver James C. (Sudbury MA), Method and apparatus for in vivo electroporation of remote cells and tissue.
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  38. Feiring Andrew J. (4454 N. Murray Ave. Milwaukee WI 53211), Method and apparatus for inducing the permeation of medication into internal tissue.
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  39. Baer Bradford W. (Menlo Park CA) Drayna Dennis T. (San Francisco CA) Lawn Richard M. (San Francisco CA) McLean John W. (San Francisco CA), Method and nucleic acid for the preparation of lecithin:cholesterol acyltransferase.
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  40. Tada Yuichi (Mobara JPX), Method for electroporation.
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  41. Mathiesen Iacob,NOX ; Lomo Terje,NOX, Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle.
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  42. Shapland James E. (Shoreview MN) Hildebrandt Keith R. (Houlton WI) Knudson Mark B. (Shoreview MN), Method for iontophoretically delivering drug adjacent to a heart.
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  43. Pliquett Uwe (Leipzig DEX) Prausnitz Mark R. (Dorchester MA) Weaver James C. (Sudbury MA) Langer Robert S. (Newton MA), Method for rapid temporal control of molecular transport across tissue.
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  44. Wenzhi Hu (Nagoya JPX), Method for separating and analyzing ions by electrostatic ion chromatography and a zwitterionic stationary phase for ion.
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  45. Carson Dennis A. ; Raz Eyal, Method for treating allergic lung disease.
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  46. Chang Donald C. (Houston TX), Method of and apparatus for cell portion and cell fusion using radiofrequency electrical pulse.
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  47. Dev Sukhendu B. ; Hofmann Gunter A., Method of treatment using electroporation mediated delivery of drugs and genes.
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  48. Carson Dennis A. (Del Mar CA) Raz Eyal (San Diego CA), Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleoti.
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  49. Carson Dennis A. ; Raz Eyal ; Howell Meredith L., Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptide.
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  50. Hofmann Gunter A. (San Diego CA) Gilbert Richard A. (Tampa FL) Hayakawa Yasuhiko (Ichikawa JPX) Heller Richard (Brandon FL) Jaroszeski Mark J. (Tampa FL), Needle electrodes for mediated delivery of drugs and genes.
    상세보기
  51. Hilliard Jeffrey L. (5256 El Cemonte Davis CA 95616) Moloney Maurice M. (Davis CA), Probe for electrofusion, electroporation, or like procedure.
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  52. Petrucco Toffolo Renato (Roveredo ITX), Sealing assembly for molds used for casting sanitary fixtures.
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  53. Mihayashi Keiji (Kanagawa JPX) Shimada Yasuhiro (Kanagawa JPX), Silver halide color photographic photosensitive materials comprising heterocyclic cyan couplers.
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  54. Blaeser David J. ; Lorentzen Cornelius Linda R. ; Willard Martin R., Stent delivery system having stent securement means.
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  55. Hofmann Gunter A. (San Diego CA), Transdermal drug delivery by electroincorporation of vesicles.
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  56. Hofmann Gunter A. (San Diego CA), Transsurface drug delivery by electrofusion of microbubbles to the tissue surface.
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  57. Nashef Basem (Geylinggasse 30 A-1130 Wien ATX) Urban Gerald (Rembrandstrasse 19 A-1020 Wien ATX) Kovac Werner (Mariahilferstrasse 127 A-1060 Wien ATX) Denck Helmuth (Kirchmayergasse 5-7 Haus C ; A-11, Tubular device for the treatment of hollow organs with electric current.
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이 특허를 인용한 특허 (6)

  1. Draghia-Akli, Ruxandra; Khan, Amir S., Antibody production elicited by a DNA vaccine delivered by electroporation.
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  2. Crouzet,Jo��l; Pitard,Bruno, Formulation of stabilized cationic transfection agent(s)/nucleic acid particles.
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  3. Vankov, Alexander; Chalberg, Thomas W.; Huie, Jr., Philip; Palanker, Daniel V., Method and apparatus for avalanche-mediated transfer of agents into cells.
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  4. Goldfarb, Paul; Rabussay, Dietmar, Method and device for treating microscopic tumors remaining in tissues following surgical resection.
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  5. Chalberg, Jr., Thomas W.; Blumenkranz, Mark; Palanker, Daniel V.; Vankov, Alexander; Huie, Jr., Philip; Marmor, Michael F.; Calos, Michele P., Ocular gene therapy using avalanche-mediated transfection.
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  6. Knoll,Istvan; Stenhede,Claes, Submerged evaporator with integrated heat exchanger.
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