Sildenafil citrate chewing gum formulations and methods of using the same
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/68
A61K-047/00
A61K-009/20
A61K-009/14
출원번호
US-0714571
(2000-11-16)
발명자
/ 주소
Gmunder, Charlean B.
Li, Weisheng
Ream, Ronald L
출원인 / 주소
Wm. Wrigley Jr. Company
대리인 / 주소
Bell, Boyd & Lloyd LLC
인용정보
피인용 횟수 :
7인용 특허 :
154
초록▼
Methods and chewing gum formulations for delivering a medicament, namely sildenafil citrate, to an individual are provided. Further, an improved dosage form and method of treating erectile dysfunction are provided. Methods of treating esophageal spasms, dysphagia, and gastroparesis utilizing chewing
Methods and chewing gum formulations for delivering a medicament, namely sildenafil citrate, to an individual are provided. Further, an improved dosage form and method of treating erectile dysfunction are provided. Methods of treating esophageal spasms, dysphagia, and gastroparesis utilizing chewing gum formulations containing sildenafil citrate are also provided.
대표청구항▼
Methods and chewing gum formulations for delivering a medicament, namely sildenafil citrate, to an individual are provided. Further, an improved dosage form and method of treating erectile dysfunction are provided. Methods of treating esophageal spasms, dysphagia, and gastroparesis utilizing chewing
Methods and chewing gum formulations for delivering a medicament, namely sildenafil citrate, to an individual are provided. Further, an improved dosage form and method of treating erectile dysfunction are provided. Methods of treating esophageal spasms, dysphagia, and gastroparesis utilizing chewing gum formulations containing sildenafil citrate are also provided. voltage controller having a sensing switch such that the thermal and electrical cycling of the pyroelectric energy converter are synchronized. 2. Apparatus of claim 1 wherein said sensing switch is a magnetic proximity switch. 3. Apparatus of claim 1 wherein the layers of pyroelectric films are stacked back to back such that no electrical insulation is required. 4. Apparatus of claim 1 wherein the stack comprises an even number of layers of pyroelectric films back-to-back, whereby charge applied to the surface of the outer facing pyroelectric films is low. 5. Apparatus of claim 1 further consisting of a number of stacks of pyroelectric films arranged in a first and second set, said second set comprising one less stack than the first set, means delivering hot fluid to the first stack of the first set, means flowing said fluid on to the first stack of the second set, means flowing said fluid on to the second stack of the first set, means to permit subsequent similar transfers of fluid to subsequent stacks until the fluid in the last stack of the first set flows out as a cooled fluid, means alternately delivering a cold fluid to the last stack of the first set, means flowing said fluid to the last stack of the second set; means flowing said fluid to the next to last stack of the first set, means permitting subsequent similar transfers of said fluid to subsequent stacks until the fluid in the first stack of the first set flows out as a heated fluid. 6. Apparatus according to claim 5 wherein the means for alternatingly delivering a flow of hot and cold fluids over the surface of the pyroelectric films comprises a tube connected to a first and second outlet pipes and an inlet pipe, a solid half-cylinder rotating in the tube alternatingly blocking the first or second outlet pipes such that the input pipe can be switched between the first and second outlet pipes. 7. Apparatus according to claim 6 wherein a magnetic proximity switch is attached to the solid half-cylinder, said proximity switch sending electric signals to the voltage controller to synchronize electrical and thermal cycling. 8. Apparatus according to claim 5 wherein the first and second set comprise a stage and a plurality of stages comprise a plate-type generator system wherein hot fluid input flowed from the first stack of the first set to a subsequent stage as a recycled hot fluid source and wherein the fluid flowed from the last stack of the first set is delivered to a subsequent stage as a recycled cold fluid source. 9. Apparatus according to claim 8 wherein there are two plate-type generator systems receiving alternate inputs of hot and cold fluid such that there is no interruption of flow of hot and cold fluid. 10. Apparatus according to claim 9 wherein the stacks are separate film assemblies thermally and electrically insulated from adjacent film assemblies. 11. Apparatus according to claim 10 wherein each stack has a thickness of less than 370 microns. 12. Apparatus according to claim 5 wherein each stack has a thermal response time of less than one second. 13. A method of converting heat to electric energy consisting of the steps of providing a first and second stack of a plurality of thin layers of pyroelectric films, applying an electric energy source to the first stack providing a variable high-voltage, applying in electric energy source to the second stack providing a constant low voltage, heating the first stack when at a high voltage while cooling the second stack when at a constant low voltage, thereafter reducing the voltage from the variable high voltage source, switching electrical connections of the first and second stacks when at the constant low voltage, increasing the voltage on the second stack to a high-voltage, heating the second stack at said high voltage while cooling the first stack at said constant low voltage, thereafter reducing the variable high voltage source. 14. The method of claim 13 wherein the steps are repeate
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