Chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C07D-487/22
C07F-013/00
A61B-005/05
출원번호
US-0739155
(2000-12-18)
발명자
/ 주소
Pandey, Ravindra K.
Grossman, Zachary
Kanter, Peter
Dougherty, Thomas J.
출원인 / 주소
Health Research, Inc.
대리인 / 주소
Dunn, Michael L.
인용정보
피인용 횟수 :
19인용 특허 :
30
초록▼
Compositions that are a chemical combination of porphyrins, chlorins, bacteriochlorins, and related tetra-pyrrolic compounds with radioactive elements such as Technetium99,Gadolinium, Indium111and radioactive iodine. When the element can form cations, the compound is usually a chelate with the porph
Compositions that are a chemical combination of porphyrins, chlorins, bacteriochlorins, and related tetra-pyrrolic compounds with radioactive elements such as Technetium99,Gadolinium, Indium111and radioactive iodine. When the element can form cations, the compound is usually a chelate with the porphyrin or chlorin structure. When the element forms anions, the compound is usually a direct chemical combination of the radioactive element into the porphyrin or chlorin structure. The invention further includes the method of using the compounds of the invention for diagnostic imaging of hyperproliferative tissue such as tumors and new blood vessel growth as is associated with the wet form of age related macular degeneration and methods of making the compounds. Compounds for MRI contrast imaging of the invention are usually Tc99,In111or Gd(III) complexes of compounds of the formula:
대표청구항▼
Compositions that are a chemical combination of porphyrins, chlorins, bacteriochlorins, and related tetra-pyrrolic compounds with radioactive elements such as Technetium99,Gadolinium, Indium111and radioactive iodine. When the element can form cations, the compound is usually a chelate with the porph
Compositions that are a chemical combination of porphyrins, chlorins, bacteriochlorins, and related tetra-pyrrolic compounds with radioactive elements such as Technetium99,Gadolinium, Indium111and radioactive iodine. When the element can form cations, the compound is usually a chelate with the porphyrin or chlorin structure. When the element forms anions, the compound is usually a direct chemical combination of the radioactive element into the porphyrin or chlorin structure. The invention further includes the method of using the compounds of the invention for diagnostic imaging of hyperproliferative tissue such as tumors and new blood vessel growth as is associated with the wet form of age related macular degeneration and methods of making the compounds. Compounds for MRI contrast imaging of the invention are usually Tc99,In111or Gd(III) complexes of compounds of the formula: Hypothermic Humans, 1997, 0161-7567:1630-1634, The American Pysiological Society. Giuffre, M., J. Finnie, D. A. Lynam, and D. Smith, Rewarming Postoperative Patients: Lights, Blankets, or Forced Warm Air, Dec. 1991, pp. 387-393, Journ. of Post Anaesthesia Nursing, vol. 6, N. 6. Guffin, A., D. Girard, and J. A. Kaplan, Shivering Following Cardiac Surgery: Hemodynamic Changes and Reversal, Feb. 1987, pp. 24-28, Journ. of Cardiothoracic Anesthesia, vol. 1, N. 1. Haley, E. C. et al. "A Randomized Trial of Tirilazad Mesylate in Patients with Acute Stroke (RANTTAS)," Stroke, 27(9):1453-1458, 1996. Iaizzo, Facial Warming Increases the Threshold for Shivering, 1999; pp. 231-239, Journ. of Neurosurgical Anesthesiology, vol. 11, No. 4. Keegan, M. T. et al. Shivering Complicating the Treatment of Neurologically Impaired Surgical and Intensive Care Unit Patients, Anesthesiology, 91(3):874-876, Sep. 1995. Kogaku "Sensor technology to control artifical organs," KLA, 22(4):295-300, Aug. 1984 (in Japanese). Kurz, Martin, et al.; "Naloxone, Meperidine, and Shivering
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Pandey, Ravindra K.; Potter, William R.; Dougherty, Thomas J., Fluorinated photosensitizers related to chlorins and bacteriochlorins for photodynamic therapy.
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