IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0790249
(2001-02-21)
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발명자
/ 주소 |
- Dae, Michael W.
- Machold, Timothy R.
- Keller, Wade A.
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출원인 / 주소 |
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대리인 / 주소 |
Buyan, Robert D.Stout, Uxa, Buyan & Mullins, LLP
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인용정보 |
피인용 횟수 :
36 인용 특허 :
20 |
초록
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A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient's vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36
A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient's vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36° C.) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient's shivering threshold (typically approximately 35.5 C.). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient's body to normothermia or near normothermia.
대표청구항
▼
A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient's vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36
A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient's vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36° C.) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient's shivering threshold (typically approximately 35.5 C.). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient's body to normothermia or near normothermia. a second diameter larger than the first diameter mounted on its distal end for compressing plaque found on the walls of the blood vessel. 10. The method of claim 1, wherein the emboli removal device is an aspiration catheter. 11. A method of performing treatment in a blood vessel while isolating emboli to a portion of the blood vessel, the method comprising the steps of: (a) delivering a guidewire having a proximal end and a distal end into the vasculature of a patient until the distal end is near to a treatment site in the blood vessel, the distal end of the guidewire having an occlusive device thereon, the occlusive device being actuatable between an expanded state in which the occlusive device engages at least a portion of the walls of the blood vessel, and a nonexpanded state in which the occlusive device does not engage the walls of the blood vessel; (b) delivering a therapy catheter comprising an elongate catheter shaft having a proximal end and a distal end into the vasculature until the distal end of the therapy catheter is near to the treatment site; (c) actuating the occlusive device at a location distal to the treatment site from its nonexpanded state to its expanded state; (d) performing treatment on the treatment site with the therapy catheter, said treatment resulting in emboli in the vessel proximal to the actuated occlusive device; (e) removing the therapy catheter from the vasculature and from the guidewire; (f) delivering an emboli removal device having a proximal end and a distal end into the vasculature until the distal end of the emboli removal device is near to the treatment site and proximal to the occlusive device; (g) removing emboli from the treatment site with the emboli removal device; and (h) de-actuating the occlusive device; wherein the occlusive device is maintained in its expanded state continuously from step (c) through step (g) to isolate emboli to the treatment site proximal to the occlusive device. 12. The method of claim 11, wherein the occlusive device is an inflatable balloon. 13. The method of claim 11, wherein the occlusive device is a self-expanding member. 14. The method of claim 11, wherein the occlusive device is a mechanically deployed member. 15. The method of claim 11, wherein the therapy catheter is delivered independently of the guidewire. 16. The method of claim 11, wherein the therapy catheter is delivered simultaneously with the guidewire. 17. The method of claim 11, wherein the therapy catheter is delivered while the occlusive device is in its nonexpanded state. 18. The method of claim 11, wherein the therapy catheter is a dilatation catheter. 19. The method of claim 11, wherein the therapy catheter performs treatment selected from the group consisting of stent delivery, drug delivery, atherectomy, shock wave generation, laser ablation, ultrasound ablation, vibration delivery and embolization element delivery for treatment of an aneurysm. 20. The method of claim 11, wherein the therapy catheter includes a lumen which is sized to override the guidewire. 21. The method of claim 11, wherein the emboli removal device is an aspiration catheter. 22. The method of claim 21, wherein the aspiration catheter is delivered over the guidewire. 23. The method of claim 11, further comprising, between steps (e) and (f), the steps of: (i) delivering a second therapy catheter comprising an elongate catheter shaft having a proximal end and a distal end into the vasculature until the distal end of the second therapy catheter is near to the treatment site; (j) performing treatment on the treatment site with the second therapy catheter, said treatment resulting in emboli in the vessel proximal to the actuated occlusive device; and (k) removing the second therapy catheter from the vasculature. 24. A method for exchanging catheters while isolating emboli to a working area in a blood vessel, comprising: delivering a guidewire having a proximal end and a distal end into the blood vessel until the distal end of the guidewire is near to a desired working area, the distal end having an occlusive device thereon; delivering a first catheter having a proximal end and a distal end over the guidewire until the distal end of the first catheter is near to the desired working area; actuating the occlusive device at a location distal to the desired working area such that the device at least partially obstructs blood flow through the vessel; performing treatment in the working area with the first catheter while continuously maintaining actuation of the occlusive device, said treatment resulting in emboli within the working area isolated proximal to the occlusive device; removing the first catheter from the guidewire while continuously maintaining actuation of the occlusive device; delivering an aspiration catheter having a proximal and a distal end over the guidewire while continuously maintaining actuation of the occlusive device such that the distal end of the aspiration catheter is located within the working area; and applying negative pressure to the aspiration catheter to remove emboli isolated within the working area. 25. The method of claim 24, wherein the first catheter is delivered independently of the guidewire. 26. The method of claim 24, wherein the first catheter is delivered simultaneously with the guidewire. 27. The method of claim 24, wherein the first catheter is delivered prior to actuating the occlusive device. 28. The method of claim 24, further comprising removing the aspiration catheter from the guidewire. 29. The method of claim 28, further comprising de-actuating the occlusive device prior to removing the aspiration catheter. 30. The method of claim 28, further comprising delivering a second catheter over the guidewire and performing a second treatment to the blood vessel. 31. The method of claim 30, further comprising re-actuating the occlusive device after delivering the second catheter over the guidewire and continuously maintaining actuation of the occlusive device during said second treatment. 32. A method for exchanging catheters, comprising: delivering a guidewire having a proximal end and a distal end into the blood vessel until the distal end of the guidewire is near to a desired working area, the distal end having an occlusive device thereon; delivering a first catheter having a proximal end and a distal end over the guidewire until the distal end of the first catheter is near to the desired working area; expanding the occlusive device at a location distal to the desired working area such that the device at least partially obstructs blood flow through the vessel; performing treatment in the working area with the first catheter while continuously maintaining the occlusive device in its expanded state, said treatment resulting in emboli within the working area; removing the first catheter from the guidewire while continuously maintaining the occlusive device in its expanded state; delivering an emboli removal device over the guidewire while continuously maintaining the occlusive device in its expanded state; and removing said emboli from the working area. 33. A method for exchanging catheters in a blood vessel, comprising: delivering a guidewire having a proximal end and a distal end into the blood vessel until the distal end of the guidewire is near to a desired working area, the distal end having an occlusive device thereon; actuating the occlusive device at a location distal to the desired working area such that the occlusive device inhibits emboli from moving past the occlusive device; delivering a first catheter having a proximal end and a distal end over the guidewire until the distal end of the first catheter is near to the desired working area; performing a first treatment in the working area with the first catheter while the occlusive device is actuated to inhibit emboli from moving past the occlusive device; removing the first catheter from
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