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Devices and compounds for treating arterial restenosis 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61F-013/00
  • A61F-002/00
출원번호 US-0585886 (2000-05-31)
발명자 / 주소
  • Zahradka, Peter
출원인 / 주소
  • Cardiovascular Solutions, Inc.
대리인 / 주소
    Morrison & Foerster LLP
인용정보 피인용 횟수 : 14  인용 특허 : 21

초록

Described herein is the use of ADPRT decoy substrates to treat or prevent proliferative disorders. In one example, MIBG is shown to prevent restenosis in damaged vessels. In one embodiment, MIBG is combined with an adhesive agent for localizing the mixture to the site of injury. As a result of this

대표청구항

1. A method of inhibiting restenosis comprising: applying an effective amount of a pharmaceutical composition comprising meta-iodobenzylguanidine (MIBG) and a pharmaceutically acceptable excipient to a damaged vessel. 2. The method according to claim 1, wherein said composition inhibits smooth

이 특허에 인용된 특허 (21)

  1. Luedders Wilmer L. (Cincinnati OH), Anti-acne composition.
  2. Thompson Edward D. (Cincinnati OH) Carter Stephen B. (Cincinnati OH) Manring Gary L. (Oxford OH), Anti-acne composition.
  3. Smith ; Donald E., Dermatological compositions.
  4. Smith ; Donald E., Dermatological compositions.
  5. Smith Donald Edward (Hamilton OH), Dermatological compositions.
  6. Smith Donald Edward (Hamilton OH), Dermatological compositions.
  7. Campbell, Patricia S.; Chandrasekaran, Santosh K., Dosage for coadministering drug and percutaneous absorption enhancer.
  8. Dinh Thomas Q. (Minnetonka MN) Tuch Ronald J. (Plymouth MN) Schwartz Robert S. (Rochester MN), Drug eluting stent.
  9. Edelman Elazer R. (Brookline MA) Adams David H. (Boston MA) Karnovsky Morris J. (Newton Centre MA), Extraluminal regulation of the growth and repair of tubular structures in vivo.
  10. Edelman Elazer R. (Brookline MA) Adams David H. (Boston MA) Karnovsky Morris J. (Newton Centre MA), Extraluminal regulation of the growth and repair of tubular structures in vivo.
  11. Lu Tianbao ; Illig Carl R. ; Tomczuk Bruce E. ; Soll Richard M. ; Subasinghe Nalin L. ; Bone Roger F., Guanidino protease inhibitors.
  12. Cooke John P. ; Schwarzacher Sverin ; Lim Tai T.,SGX ; Yeung Alan C., Intramural delivery of nitric oxide enhancer for inhibiting lesion formation after vascular injury.
  13. Patel Dinesh C. (Murray UT) Chang Yunik (Lakewood NJ), Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols.
  14. Rajadhyaksha Vithal J. (Mission Viejo CA), Penetration enhancers for transdermal drug delivery of systemic agents.
  15. Lee Eun S. (Redwood City CA) Yum Su Il (Los Altos CA), Permeation enhancer comprising ethanol and monoglycerides.
  16. Cheng Yu-Ling (Cupertino CA) Nedberge Diane E. (Los Altos CA) Sugihara Edna (Mountain View CA), Skin permeation enhancer compositions using glycerol monolaurate.
  17. Taskovich Lina T. (Palo Alto CA), Skin permeation enhancer compositions using glycerol monooleate.
  18. Fawzi Mahdi B. (Fairfield OH), Topical antimicrobial anti-inflammatory compositions.
  19. Gale Robert M. (Los Altos CA) Enscore David J. (Sunnyvale CA) Nedberge Diane E. (Los Altos CA) Nelson Melinda (Sunnyvale CA) Cheng Yu-Ling (Cupertino CA) Libicki Shari B. (Palo Alto CA), Transdermal administration of progesterone, estradiol esters, and mixtures thereof.
  20. Sanders Harold F. (Palo Alto CA) Cheng Yu-Ling (Cupertino CA) Enscore David J. (Saratoga CA) Libicki Shari B. (Palo Alto CA), Transdermal drug composition with dual permeation enhancers.
  21. Regunathan Soundararajan (Avenel NJ) Reis Donald J. (New York NY), Treating disorders mediated by vascular smooth muscle cell proliferation.

이 특허를 인용한 특허 (14)

  1. Lundstedt, Torbjorn; Seifert, Elisabeth; Lek, Per; Boman, Arne, Aminoguanidines as melanocortin receptor ligands.
  2. Rabiner, Robert A.; Hare, Bradley A.; Marciante, Rebecca I.; Varady, Mark J., Apparatus and method for an ultrasonic medical device operating in torsional and transverse modes.
  3. McKearn, John; Blitzer, Jeremy, Controlled release oral pharmaceutical dosage forms comprising MGBG.
  4. Helmus, Michael N.; Cunanan, Crystal M.; Tremble, Patrice, Delivery systems for periadventitial delivery for treatment of restenosis and anastomotic intimal hyperplasia.
  5. Helmus,Michael N.; Cunanan,Crystal M.; Tremble,Patrice, Delivery systems for periadventitial delivery for treatment of restenosis and anastomotic intimal hyperplasia.
  6. Kutryk, Michael John Bradley; Cottone, Jr., Robert J.; Rowland, Stephen M., Medical device with coating that promotes endothelial cell adherence.
  7. Rabiner, Robert; Hare, Bradley A., Medical systems and related methods.
  8. McKearn, John; Blitzer, Jeremy, Method of treatment with anti-inflammatory and analgesic compounds which are GI-, renal-, and platelet-sparing.
  9. Blitzer, Jeremy; McKearn, John, Methods and compositions for treatment of demyelinating diseases.
  10. McKearn, John; Blitzer, Jeremy, Methods of treating pain with MGBG.
  11. McKearn, John; Blitzer, Jeremy, Pharmaceutical for oral delivery comprising MGBG and methods of treating disease.
  12. Hadlock, Kenneth G.; Lancero, Hope; Yu, Stephanie; Do, Hien Kim, Regulation of osteopontin.
  13. Rabiner,Robert A.; Hare,Bradley A., Ultrasonic device for tissue ablation and sheath for use therewith.
  14. Rabiner,Robert A.; Hare,Bradley A.; Fischer,David M.; Levine,Andy, Ultrasonic medical device operating in a transverse mode.
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