초록 ▼

A coffee aroma composition and a particulate coffee beverage preparation aroma composition. The aroma composition includes a coffee aroma constituent and a volatile organic carrier constituent. The carrier is in the liquid state at 25° C., and has a vapor pressure of at least 0.01 mm Hg at 25° C., a

A coffee aroma composition and a particulate coffee beverage preparation aroma composition. The aroma composition includes a coffee aroma constituent and a volatile organic carrier constituent. The carrier is in the liquid state at 25° C., and has a vapor pressure of at least 0.01 mm Hg at 25° C., a boiling point in the range of 25 to 250° C., a density of less than 1.0 g/cc, and water solubility of not more than about 10% by weight at 25° C.

대표청구항 ▼

A coffee aroma composition and a particulate coffee beverage preparation aroma composition. The aroma composition includes a coffee aroma constituent and a volatile organic carrier constituent. The carrier is in the liquid state at 25° C., and has a vapor pressure of at least 0.01 mm Hg at 25° C., a

A coffee aroma composition and a particulate coffee beverage preparation aroma composition. The aroma composition includes a coffee aroma constituent and a volatile organic carrier constituent. The carrier is in the liquid state at 25° C., and has a vapor pressure of at least 0.01 mm Hg at 25° C., a boiling point in the range of 25 to 250° C., a density of less than 1.0 g/cc, and water solubility of not more than about 10% by weight at 25° C. the following conditions: (1) the core be located in the innermost portion of the controlled-release formulation; (2) said formulation have at least one release control layer covering the core, with at least one additional release control layer and/or drug release layer being optionally present; (3) the release control layer(s) alternate with the drug release layer(s); (4) the outermost layer be either the release control layer or the drug release layer; (5) if the outermost layer is the drug release layer, it may cover all or part of the surface of the underlying release control layer; (6) the drugs to be contained in the core and the drug release layer of said formulation should be selected independently of each other; (7) the core and the drug release layers be optionally formulated to permit immediate release or slow release of the drugs contained; and (8) if two or more drugs are to be contained in the core and the drug release layer(s) of said formulation, said core and a single drug release layer optionally each be composed of more than one layer containing only one drug. 2. The controlled-release formulation according to claim 1, whose dosage form is a solid preparation. 3. The controlled-release formulation according to claim 2, whose dosage form is a tablet. 4. The controlled-release formulation according to claim 1, which contains an immediate-release portion. 5. The controlled-release formulation according to claim 4, whose core comprises the immediate-release portion. 6. The controlled-release formulation according to claim 4, wherein the immediate-release portion contains a different drug from the drug the release of which is to be controlled. 7. The controlled-release formulation according to claim 1, wherein the base is fumaric acid. 8. The controlled-release formulation according to claim 1, wherein the base is DL-tryptophan. 9. A process for producing a controlled-release formulation that comprises at least the following step A: A. molding a core containing at least one drug the release of which is to be controlled and forming a release control layer by covering said core with a component that has a pharmaceutically acceptable additive incorporated in at least one base selected from among fumaric acid and DL-tryptophan and which is substantially free from the drugs the release of which is to be controlled and thereby forming a shape of a dual structure; said step A being optionally followed by the following step B, or the following steps B and C, or the following steps B-D, or the following steps B-E: B. covering or overlaying the shape of a dual structure with a component containing at least one drug the release of which is to be controlled and thereby forming a drug release layer; C. covering the shape obtained in said step B with a component that has a pharmaceutically acceptable additive incorporated in at least one base selected from among fumaric acid and Dl-tryptophan and which is substantially free from the drugs the release of which is to be controlled and thereby forming a release control layer; D. covering or overlaying the shape obtained in said step C with a component containing at least one drug the release of which is to be controlled and thereby forming a drug release layer; and E. repeating said step C of forming a release control layer and said step D of forming a drug release layer at least once to produce the desired controlled-release formulation which satisfies the following conditions: (1) the core be located in the innermost portion of the controlled-release formulation; (2) said formulation have at least one release control layer covering the core, with at least one additional release control layer and/or drug release layer being optionally present; (3) the release control layer(s) alternate with the drug release layer(s); (4) the outermost layer may be either the release control layer or the drug release layer; (5) if the outermost layer is the drug releas e layer, it may cover all or part of the surface of the underlying release control layer; (6) the drugs to be contained in the core and the drug release layer of said formulation should be selected independently of each other; (7) the core and the drug release layers may be formulated to permit immediate release or slow release of the drugs contained; and (8) if two or more drugs are to be contained in the core and the drug release layer(s) of said formulation, said core and a single drug release layer may each be composed of more than one layer containing only one drug. 10. The process according to claim 9, wherein the release control layer(s) and the drug release layer(s) are formed by means of a tablet machine or a coating machine. 11. The process according to claim 9, which is used to produce a solid preparation. 12. The process according to claim 10, which is used to produce a tablet. 13. The process according to claim 9, which is used to produce a formulation containing an immediate-release portion. 14. The process according to claim 13, which is used to produce a formulation whose core comprises the immediate-release portion. 15. The process according to claim 13, which is used to produce a formulation wherein the immediate-release portion contains a different drug from the drug the release of which is to be controlled. 16. The process according to claim 9, which is used to produce a formulation wherein the drug the release of which is to be controlled is nicorandil. 17. The process according to claim 9, which is used to produce a formulation wherein the base is fumaric acid. 18. The process according to claim 9, which is used to produce a formulation wherein the base is Dl-tryptophan. 19. The controlled-release formulation according to claim 1 wherein the drug the release of which is to be controlled is nicorandil. oil base comprises an oil substitute. 4. The process of claim 1, wherein step (b) comprises adding from about 1.8% to about 2% silica to the oil base. 5. The process of claim 1, wherein step (d) comprises homogenization at a pressure of at least about 2000 psi. 6. The process of claim 4, wherein step (d) comprises homogenization at a pressure of at least about 2000 psi. 7. The process of claim 6, wherein step (e) comprises cooling to from about 70° F. to about 80° F. 8. The process of claim 6, wherein the additional ingredient of step (f) comprises a flavor enhancing agent, lecithin, silicone polymer, or mixtures thereof. 9. The process of claim 6, wherein said flavor enhancing agent has an average particle size of less than about 30 microns. 10. The process of claim 9, wherein said flavor enhancing agent has an average particle size of less than about 10 microns. 11. The process of claim 4, wherein said flavor enhancing agent has an average particle size of less than about 30 microns. 12. The process of claim 11, wherein said flavor enhancing agent has an average particle size of less than about 10 microns. 13. The process of claim 4, wherein step (e) comprises cooling to from about 70° F. to about 80° F. 14. The process of claim 4, wherein the additional ingredient of step (f) comprises a flavor enhancing agent, lecithin, silicone polymer, or mixtures thereof. 15. The process of claim 1, wherein step (e) comprises cooling to from about 70° F. to about 80° F. 16. The process of claim 15, wherein the additional ingredient of step (f) comprises a flavor enhancing agent, lecithin, silicone polymer, or mixtures thereof. 17. The process of claim 15, wherein said flavor enhancing agent has an average particle size of less than about 30 microns. 18. The process of claim 17, wherein said flavor enhancing agent has an average particle size of less than about 10 microns. 19. The process of claim 1, wherein the additional ingredient of step (f) comprises a flavor enhancing agent, lecithin, silicone polymer, or mixtures thereof. 20. The process of claim 1, wherein said flavor enhancing agent has an average particle size of less than about 30 microns. 21. The process of claim 20, wherein said flavor enhancing agent has an average particle size of less than about 10 microns. 22. A process for preparing a food preparation composition in the form of a stable gel, comprising the steps of: (a) providing an oil base; (b) adding from about 1.5% to about 2.2% silica to the oil base; (c) mixing the silica with the oil base to form a mixture; (d) homogenizing the mixture at a pressure of at least about 2000 psi; (e) cooling the mixture; and (f) thoroughly mixing into the mixture at least one additional ingredient to form said food preparation composition. 23. The process of claim 22 wherein step (b) comprises adding from about 1.8% to about 2% silica to the oil base. 24. The process of claim 23, wherein the silica of step (b) comprises less than about 3.5% moisture. 25. The process of claim 24, wherein step (d) comprises homogenization at a pressure of at least about 2000 psi. 26. The process of claim 24, wherein step (e) comprises cooling to from about 70° F. to about 80° F. 27. The process of claim 24, wherein the additional ingredient of step (f) comprises a flavor enhancing agent, lecithin, silicone polymer, or mixtures thereof. 28. The process of claim 24, wherein said flavor enhancing agent has an average particle size of less than about 30 microns. 29. The process of claim 28, wherein said flavor enhancing agent has an average particle size of less than about 10 microns. 30. The process of claim 22, wherein the silica of step (b) comprises less than about 3.5% moisture. 31. A process for preparing a food preparation composition in the form of a stable gel, comprising the steps of: (a) providing an oil base; (b) adding from about 1.5% to about 2.2% silica to the oil base; (c) mixing the silica with the oil base to form