Thermal preactivation of gaseous precursor filled compositions
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-008/00
A61K-009/127
출원번호
US-0929847
(1997-09-15)
발명자
/ 주소
Unger, Evan C.
출원인 / 주소
Bristol-Myers Squibb Medical Imaging, Inc.
대리인 / 주소
Woodcock Washburn LLP
인용정보
피인용 횟수 :
72인용 특허 :
236
초록▼
The present invention describes, among other things, the surprising discovery that gaseous precursor filled compositions are profoundly more effective as acoustically active contrast agents when they are thermally preactivated to temperatures at or above the boiling point of the instilled gaseous pr
The present invention describes, among other things, the surprising discovery that gaseous precursor filled compositions are profoundly more effective as acoustically active contrast agents when they are thermally preactivated to temperatures at or above the boiling point of the instilled gaseous precursor prior to their in vivo administration to a patient. Further optimization of contrast enhancement is achieved by administering the gaseous precursor filled compositions to a patient as an infusion. Enhanced effectiveness is also achieved for ultrasound mediated targeting and drug delivery.
대표청구항▼
The present invention describes, among other things, the surprising discovery that gaseous precursor filled compositions are profoundly more effective as acoustically active contrast agents when they are thermally preactivated to temperatures at or above the boiling point of the instilled gaseous pr
The present invention describes, among other things, the surprising discovery that gaseous precursor filled compositions are profoundly more effective as acoustically active contrast agents when they are thermally preactivated to temperatures at or above the boiling point of the instilled gaseous precursor prior to their in vivo administration to a patient. Further optimization of contrast enhancement is achieved by administering the gaseous precursor filled compositions to a patient as an infusion. Enhanced effectiveness is also achieved for ultrasound mediated targeting and drug delivery. 000, Bruckner et al., 106/403; US-5595347, 19970100, Walpole; US-5601630, 19970200, Hoecker; US-5679131, 19971000, Obushenko; US-5688439, 19971100, Chopin et al., 252/309; US-5698177, 19971200, Pratsinis et al., 423/613; US-5698205, 19971200, Bruckner et al.; US-5714260, 19980200, Okuda et al., 428/402; US-5730774, 19980300, Hollitt et al.; US-5730795, 19980300, Herkimer; US-5770310, 19980600, Noguchi et al., 428/403; US-5826162, 19981000, Aral et al.; US-5833892, 19981100, Gurav et al.; US-5840111, 19981100, Wiederhoft et al., 106/436; US-6001326, 19991200, Kim et al., 423/598; US-6037289, 20000300, Chopin; US-6099634, 20000800, Uenishi et al., 106/436
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이 특허에 인용된 특허 (236)
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