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Polymers for delivery of nucleic acids 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-048/00
  • A61K-009/127
  • C12N-015/85
  • C12N-005/00
  • C12N-015/63
출원번호 US-0336390 (1999-06-18)
발명자 / 주소
  • Mao, Hai-Quan
  • Lin, Kevin Y.
  • Hendriks, Bart S.
  • Leong, Kam W.
  • Haller, Michael F.
출원인 / 주소
  • Johns Hopkins University School of Medicine
대리인 / 주소
    Foley Hoag, LLP
인용정보 피인용 횟수 : 30  인용 특허 : 32

초록

The present invention relates to compositions and methods for delivery of nucleic acids. In particular, the invention provides a polymeric delivery formulation including a nucleic acid to be transfected into a host cell, formulated in a biodegradable polymer having phosphorous-based linkages.

대표청구항

The present invention relates to compositions and methods for delivery of nucleic acids. In particular, the invention provides a polymeric delivery formulation including a nucleic acid to be transfected into a host cell, formulated in a biodegradable polymer having phosphorous-based linkages.

이 특허에 인용된 특허 (32)

  1. Leong Kam W. (Ellicott City MD), Biocompatible and biodegradable poly (phosphoester-urethanes).
    상세보기
  2. DeLuca Patrick P. (Lexington KY) Rypacek Frantisek (Leckova CSX), Biodegradable microspheres as a carrier for macromolecules.
    상세보기
  3. Mao Hai-quan ; Leong Kam W., Biodegradable poly (phosphoester-co-desaminotyrosyl L-tyrosine ester) compounds, compositions, articles and methods for.
    상세보기
  4. Leong Kam W. (Perry Hall MD), Biodegradable poly(phosphate esters).
    상세보기
  5. Leong Kam W. (8525 E. Heathrow Ct. Perry Hall MD), Biodegradable poly(phosphoesters).
    상세보기
  6. Mao Hai-Quan ; Leong Kam W. ; Zhao Zhong ; English James P., Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same.
    상세보기
  7. Gorman Cori M., Cationic lipid DNA complexes for gene targeting.
    상세보기
  8. Ludwig Nelson H. (Greenfield IN) Ose Earl E. (Greenfield IN), Controlled release formulations and method of treatment.
    상세보기
  9. Pardoll Drew ; Azhari Rosa,ILX ; Leong Kam W. ; Golumbek Paul ; Jaffee Elizabeth ; Levitsky Hyam ; Lazenby Audrey, Controlled release of pharmaceutically active substances for immunotherapy.
    상세보기
  10. Leong Kam W. ; Azhari Rosa V.,ILX, Controlled release of pharmaceutically active substances from coacervate microcapsules.
    상세보기
  11. Felgner Philip L. (Rancho Santa Fe CA) Wolff Jon A. (Madison WI) Rhodes Gary H. (Leucadia CA) Malone Robert W. (Chicago IL) Carson Dennis A. (Del Mar CA), Delivery of exogenous DNA sequences in a mammal.
    상세보기
  12. Login Robert B. (Woodhaven MI) Newkirk David D. (Woodhaven MI), Linear saturated polyesters of phosphoric acid and halogenated diols as flame-retardant additives and coatings.
    상세보기
  13. Login Robert B. (Woodhaven MI) Newkirk David D. (Woodhaven MI), Linear saturated polyesters of phosphoric acid and halogenated diols as flame-retardant additives and coatings.
    상세보기
  14. Login Robert B. (Woodhaven MI) Newkirk David D. (Woodhaven MI), Linear saturated polyesters of phosphoric acid and halogenated diols as flame-retardant additives and coatings.
    상세보기
  15. Tice Thomas R. (Birmingham AL) Gilley Richard M. (Birmingham AL) Eldridge John H. (Birmingham AL) Staas Jay K. (Birmingham AL) Hollingshead Melinda G. (Birmingham AL) Shannon William M. (Birmingham A, Method of potentiating an immune response.
    상세보기
  16. Tice Thomas R. (Birmingham AL) Gilley Richard M. (Birmingham AL), Microencapsulation process and products therefrom.
    상세보기
  17. Hedley Mary Lynne ; Curley Joanne M. ; Langer Robert S., Microparticles for delivery of nucleic acid.
    상세보기
  18. Kohn Joachim (Brookline MA) Langer Robert S. (Somerville MA), Non-peptide polyamino acid bioerodible polymers.
    상세보기
  19. Landh Tomas (Lund SEX) Larsson Kare (Bjrred SEX), Particles, method of preparing said particles and uses thereof.
    상세보기
  20. Reader Arthur M. (Waynesboro VA), Phosphonate polymers.
    상세보기
  21. Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill Jennifer L. (Austin TX), Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
    상세보기
  22. Zalipsky Samuel (Princeton NJ) Bolikal Durgadas (Edison NJ) Nathan Aruna (Piscataway NJ) Kohn Joachim B. (Highland Park NJ), Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon.
    상세보기
  23. Engelhardt Fritz (Frankfurt am Main DEX) Steckelberg Willi (Hofheim/TS DEX) Keil Karl-Heinz (Hanau DEX) Zerrer Ralf (Alzenau DEX), Polycondensates containing phosphinic and phosphonic acid groups.
    상세보기
  24. Yeh Ming-Kung,TWX ; Coombes Alan Gerald,GBX ; Jenkins Paul George,GBX ; Davis Stanley Stewart,GBX, Polymer microparticles for drug delivery.
    상세보기
  25. Schacht Etienne (Staden BEX) Crommen Jan (Gent BEX), Polyphosphazenes and their synthesis.
    상세보기
  26. DeLuca Patrick P. (Lexington KY) Kanke Motoko (Fukuyama JPX) Sato Toyomi (Tokyo CA JPX) Schroeder Hans G. (Encinitas CA), Porous microspheres for drug delivery and methods for making same.
    상세보기
  27. De Luca Patrick P. (Lexington KY) Rypacek Frantisek (Leckova CZX), Preparation of biodegradable microspheres useful as carriers for macromolecules.
    상세보기
  28. Zhao Zhong, Solution polymerization of high molecular weight poly(phosphoesters) in toluene.
    상세보기
  29. Kohn Joachim B. (Highland Park NJ) Pulapura Satish K. K. (Piscataway NJ), Synthesis of amino acid-derived bioerodible polymers.
    상세보기
  30. Kossovsky Nir (Los Angeles CA) Hnatyszyn H. James (Los Angeles CA) Gelman Andrew (Los Angeles CA), Targeted transfection nanoparticles.
    상세보기
  31. Unger Evan C. (Tucson AZ) Fritz Thomas A. (Tucson AZ) Matsunaga Terry (Tucson AZ) Ramaswami VaradaRajan (Tucson AZ) Yellowhair David (Tucson AZ) Wu Guanli (Tucson AZ), Therapeutic drug delivery systems.
    상세보기
  32. Zhao Zhong ; Mao Hai-quan ; Leong Kam W., Two-stage solution polymerization of high molecular weight poly(phosphoesters).
    상세보기

이 특허를 인용한 특허 (30)

  1. Ritter,Vladimir; Ritter,Marina; Tendler,Mark; Feitelberg,Lev, Compositions comprising microspheres with anti-inflammatory properties for healing of ocular tissues.
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  2. Thorstensen-Woll, Robert William; Smelko, Joseph, Container seal with removal tab and security ring seal.
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  3. Thorstensen-Woll, Robert William, Inner seal with a sub tab layer.
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  4. Thorstensen-Woll, Robert William, Inner seal with a sub tab layer.
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  5. Thorstensen-Woll, Robert William, Inner seal with a sub tab layer.
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  6. Thorstensen-Woll, Robert William, Inner seal with a sub tab layer.
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  7. Thorstensen-Woll, Robert William, Inner seal with a sub tab layer.
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  8. Thorstensen-Woll, Robert William, Inner seal with a sub tab layer.
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  9. Thorstensen-Woll, Robert William, Inner seal with a sub tab layer.
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  10. Thorstensen-Woll, Robert William, Inner seal with an overlapping partial tab layer.
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  11. Thorstensen-Woll, Robert William, Inner seal with an overlapping partial tab layer.
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  12. Norman, Gary L.; Shums, Zakera, Methods and assays for detecting GP73-specific autoantibodies.
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  13. Bonnet, Isabelle; De Matteis, Charlotte; Perrier, Eric, Particles comprising a biopolymer which is degradable under the effect of an electromagnetic wave as emitted by a solar radiation.
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  14. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Costantino, Henry R.; Smith, Christine; Lokensgard, David M.; Fineman, Mark; Ong, John, Poly(lactide-co-glycolide) based sustained release microcapsules comprising a polypeptide and a sugar.
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  15. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Costantino, Henry R., Polymer-based sustained release device.
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  16. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Costantino, Henry R., Polymer-based sustained release device.
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  17. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Costantino, Henry R., Polymer-based sustained release device.
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  18. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Costantino, Henry R., Polymer-based sustained release device.
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  19. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Costantino, Henry R., Polymer-based sustained release device.
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  20. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Fineman, Mark; Smith, Christine; Ong, John; Lokensgard, David M.; Costantino, Henry R., Polymer-based sustained release device.
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  21. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Fineman, Mark; Smith, Christine; Ong, John; Lokensgard, David; Costantino, Henry R., Polymer-based sustained release device.
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  22. Wright,Steven G.; Christenson,Troy; Yeah,Thean Y.; Rickey,Michael E.; Hotz,Joyce M.; Kumar,Rajesh; Costantino,Henry R., Polymer-based sustained release device.
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  23. Rickey, Michael E.; Ramstack, J. Michael; Kumar, Rajesh, Residual solvent extraction method and microparticles produced thereby.
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  24. Rickey, Michael E.; Ramstack, J. Michael; Kumar, Rajesh, Residual solvent extraction method and microparticles produced thereby.
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  25. Rickey, Michael E.; Ramstack, J. Michael; Kumar, Rajesh, Residual solvent extraction method and microparticles produced thereby.
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  26. McLean, Andrew Fenwick; O'Brien, David John; Sachs, Victor; Thornhill, Craig Warren, Seal stock laminate.
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  27. Thorstensen-Woll, Robert William; Brucker, Steven A., Sealing member with removable portion for exposing and forming a dispensing feature.
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  28. Thorstensen-Woll, Robert William; Smelko, Joseph, Tabbed sealing member with improved heat distribution for a container.
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  29. Thorstensen-Woll, Robert William; Smelko, Joseph, Tabbed sealing member with improved heat distribution for a container.
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  30. Thorstensen-Woll, Robert William, Tamper evident tabbed sealing member having a foamed polymer layer.
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