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The solid state thermoelectric device includes at least an array of metallic conductor and/or N-type and P-type semiconductor thermoelectric elements assembled on a printed circuit and forming thermoelectric couples electrically connected in series. The structure of the device is formed of at least

The solid state thermoelectric device includes at least an array of metallic conductor and/or N-type and P-type semiconductor thermoelectric elements assembled on a printed circuit and forming thermoelectric couples electrically connected in series. The structure of the device is formed of at least a pair of laminated elements each formed of a supporting layer made of polymeric material and at least a layer of conductive material, a layer of joining material interposed between the two laminated elements of polymeric material for firmly connecting them one to the other. The printed circuit is made from the layer of conductive material of the laminated elements and electrically connects in series the thermoelectric elements to form thermoelectric couples having the hot or cold sides, respectively, on only one side of the structure. The structure of the thermoelectric device has a spirally or circularly wound configuration.

대표청구항 ▼

The solid state thermoelectric device includes at least an array of metallic conductor and/or N-type and P-type semiconductor thermoelectric elements assembled on a printed circuit and forming thermoelectric couples electrically connected in series. The structure of the device is formed of at least

The solid state thermoelectric device includes at least an array of metallic conductor and/or N-type and P-type semiconductor thermoelectric elements assembled on a printed circuit and forming thermoelectric couples electrically connected in series. The structure of the device is formed of at least a pair of laminated elements each formed of a supporting layer made of polymeric material and at least a layer of conductive material, a layer of joining material interposed between the two laminated elements of polymeric material for firmly connecting them one to the other. The printed circuit is made from the layer of conductive material of the laminated elements and electrically connects in series the thermoelectric elements to form thermoelectric couples having the hot or cold sides, respectively, on only one side of the structure. The structure of the thermoelectric device has a spirally or circularly wound configuration. 53, (Oct. 1984). French, A.L., et al., "Poisoning with the North American Jack O' Lantern Mushroom", Clinical Toxicology, 26 (1&2), 81-88, (1988). Giovanella, B.C., et al., "Correlation Between Response to Chemotherapy of Human Tumors in Patients and in Nude Mice", Cancer, 52, 1146-1152, (1983). Giovanella, B.C., et al., "DNA Topoisomerase I-Targeted Chemotherapy of Human Colon Cancer in Xenografts", Science, 246 (4933), 1046-1048, (Nov. 24, 1989). Goldin, A., et al., "Current Results of the Screening Program at the Division of Cancer treatment, National Cancer Institute", Europ. J. Cancer, 17, 129-142, (1981). Goldin, A., et al., "Historical Development and Current Strategy of the National Cancer Institute Drug Development Program", In: Methods of Cancer Research, vol. XVI, Cancer Drug Development Part A, Chapter V, Academic Press, Inc., New York, 165-245, (1979). Greene, T.W., Protective Groups in Organic Synthesis, Chapters 4, 5 & 6, John Wiley & Sons, Inc., New York, pp. 114-217, (1981). Hanson, J.R., et al., "Studies in Terpenoid Biosynthesis. Part XV. Biosynthesis of the Sesquiterpenoid Illuden M", Journal of the Chemical Society, Perkin Transactions I, 876-880, (1976). Hara, M., et al., "6-Deoxyilludin M, a New Antitumor Antibiotic: Fermentation, Isolation and Structural Identification", The Journal of Antibiotics, 40, 1643-1646, (Nov., 1987). Harttig, U., et al., "Leaianafulvene, a Sesquiterpenoid Fulvene Derivative from Cultures of Mycena Leaiana", Phytochemistry, 29 (12), 3942-3944, (1990). Hirono, I., et al., "Repreoduction of Acute Bracken Poisoning in a Calf with Ptaquiloside, a Bracken Constituent", The Veterinary Record, 115 (15), 375-378, (Oct., 1984). Inoue, K., et al., "Antitumor Efficacy of Seventeen Anticancer Drugs in Human Breast Cancer Xenograft (MX-1) Transplantated in Nude Mice", Cancer Chemother. Pharamacol., 10, 182-186, (1983). Kawato, Y., et al., "Antitumor Activity of a Camptothecin Derivative, CPT-11, Against Human Tumor Xenografts in Nude Mice", Cancer Chemother. Pharmacol., 28, 192-198, (1991). Kelner, M.J., et al., "In Vitro and In Vivo Studies on the Anticancer Activity of Dehydroilluden M", Anticancer Research, 15, 873-878, (1995). Kelner, M.J., et al., "Nonresponsiveness of the Metastatic Human Lung Carcinoma MV522 Xenograft to Conventional Anticancer Agents", Anticancer Research, 15, 867-872, (1995). Kelner, M.J., et al., "Preclinical Evaluation of Illudens as Anticancer Agents", Cancer Research, 47, 3186-3189, (1987). Kelner, M.J., et al., "Preclinical Evaluation of Illudens as Anticancer Agents: Basis for Selective Cytotoxicity", J. Natl. Cancer Inst., 82 (19), 1562-1565, (1987). Matsumoto, T., et al., "An Alternative Synthesis of Illuden M", Tetrahedron Letters, 14, 1171-1174, (Mar. 1970). Matsumoto, T., et al., "Synthesis of Illudin S", Tetrahedron Letters, 23, 2049-2052, (May 1971). McMorris, T.C., et al., "(Hydroxymethyl) Acyfulvene: An Illuden Derivative with Superior Antitumor Properties", Journal of Natural Products, 59 (9), 896-899, (Sep. 1996). McMorris, T.C., et al., "(Hydroxymethyl)acylfulvene: An Illudin Derivative with Superior Antitumor Properties", Chemical Abstracts, abstract No. 196032, vol. 125, No. 15, (Oct. 7, 1996). McMorris, T.C., et al., "Acylfulvenes, a New Class of Potent Antitumor Agents", Experientia, 52 (1), 75-80, (Apr. 21, 1995). McMorris, T.C., et al., "An Acetal Derivative of Illudin S with Improved Antitumor Activity", Tetrahedron letters, 38 (10), 1697-1698, (1997). McMorris, T.C., et al., "Design and Synthesis of Antitumor Acylfulvenes", The Journal of Organic Chemistry 62(9), 3015-3018, (1997). McMorris, T.C., et al., "Fungal Metabolites. The Structures of the Novel Sesquiterpenoids Illudin -S and -M", J. of Amer. Chem. Soc., 87 (7), 1594-1600, (1965). McMorris, T.C., et al., "Metabolism of Antitumor Acylfulvene by Rat Liver Cytosol", Biochemical Pharmacology, 57, pp. 83-88, (1999). McMorris, T.C., et al., "On the Mechanism of