Container with multi-phase composition for use in diagnostic and therapeutic applications
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-008/00
A61K-009/127
출원번호
US-0052075
(1998-03-31)
발명자
/ 주소
Unger, Evan C.
Matsunaga, Terry
Yellowhair, David
출원인 / 주소
Bristol-Myers Squibb Medical Imaging, Inc.
대리인 / 주소
Woodcock Washburn LLP
인용정보
피인용 횟수 :
68인용 특허 :
216
초록
A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.
대표청구항▼
A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed. lene or hexylene group. 3. The silver halide
A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed. lene or hexylene group. 3. The silver halide photographic light-sensitive material according to claim 1, wherein the carboxylate salt denoted by R in general formulae (I) and (II) is an alkali metal salt, an alkaline earth metal salt, an ammonium salt or an amine salt. 4. The silver halide photographic light-sensitive material according to claim 1, wherein said compound represented by general formulae (I) or (II) is added in an amount of 1×10-5mol/mol of silver to 1×10-2mol/mol of silver. 5. The silver halide photographic light-sensitive material according to claim 1, wherein said compound represented by general formulae (I) or (II) is added in an amount of 1×10-4mol/mol of silver to 5×10-3mol/mol of silver. 6. The silver halide photographic light-sensitive material according to claim 1, further comprising light-insensitive silver halide grains. 7. The silver halide photographic light-sensitive material according to claim 1, wherein said light-sensitive silver halide emulsion layer comprises at least two types of silver halide emulsion having different halogen compositions. 8. The silver halide photographic light-sensitive material according to claim 1, wherein said light-sensitive silver halide emulsion layer comprises at least two types of light-sensitive silver halide emulsion having different grain sizes. 9. The silver halide photographic light-sensitive material according to claim 8, wherein said at least two types of light-sensitive silver halide emulsion have average grain edge lengths that are different by at least 10%. 10. The silver halide photographic light-sensitive material according to claim 1, wherein the light-sensitive silver halide emulsion layer or the hydrophilic colloid layer comprises at least one type of hydrazine derivative represented by general formula (D) as a nucleating agent, (In the formula, R20denotes an aliphatic group, an aromatic group or a heterocyclic group, R10denotes hydrogen or a blocking group, G10denotes a --CO--, --COCO--, --C(=S)--, --SO2--, --SO--, or --PO(R30)-- group (R30denotes the same group as R10,and R30and R10may be identical to or different from each other), or an iminomethylene group. A10and A20both denote hydrogen or one thereof denotes hydrogen and the other thereof denotes a substituted or unsubstituted alkylsulfonyl group, a substituted or unsubstituted arylsulfonyl group, or a substituted or unsubstituted acyl group.) 11. The silver halide photographic light-sensitive material according to claim 1, wherein the light-sensitive silver halide emulsion layer or the hydrophilic colloid layer comprises an amine derivative, an onium salt, a disulfide derivative or a hydroxymethyl derivative as a nucleation accelerator. 12. A method for processing the silver halide photographic light-sensitive material according to claim 1, wherein the amount of developing solution replenished is 200 ml or less per m2of the light-sensitive material. 13. The method according to claim 12 for continuously processing a silver halide photographic light-sensitive material, wherein the developing solution comprises a dihydroxybenzene series developing agent and an auxiliary developing agent that shows superadditivity therewith. 14. The method for processing a silver halide photographic light-sensitive material according to claim 12, wherein the developing solution comprises as a developing agent a combination of a dihydroxybenzene and/or an ascorbic acid derivative and a 1-phenyl-3-pyrazolidone or a p-aminophenol. 15. The method for processing a silver halide photographic light-sensitive material according to claim 12, wherein said developing solution has a pH in the range of 9.0 to 12.0. 16. The method for processing a silver halide photographic light-sensitive material according to claim 12, wherein said developing solut ion has a pH in the range of 9.0 to 11.0. 17. The method for processing a silver halide photographic light-sensitive material according to claim 12, wherein the amount of developing solution replenished is in the range of 30 to 200 ml per m2of the light-sensitive material. 18. The method for processing a silver halide photographic light-sensitive material according to claim 12, wherein the amount of developing solution replenished is in the range of 30 to 180 ml per m2of the light-sensitive material. B>x,ZrSiOx,NiSix,TaSixand ZrSiO. 8. The phase shift mask according to claim 7, wherein said phase shifting material layer is MoSixOyNzhaving a thickness of about 50 nm to about 200 nm. 9. The phase shift mask according to claim 1, wherein the etch stop layer has a plasma etch selectivity with respect to the phase shifting layer of greater than 5 to 1. 10. The phase shift mask according to claim 1, wherein the etch stop layer has a plasma etch selectivity with respect to the phase shifting layer of greater than 10 to 1. 11. The phase shift mask according to claim 1, wherein the etch stop layer has a selectivity with respect to the substrate of between 5 to 1 and 100 to 1. 12. A method of fabricating a phase shift mask, comprising: providing a transparent substrate including a non-opaque etch stop layer disposed on the substrate, a phase shifting layer comprising a phase shifting material disposed on the etch stop layer, and a masking layer disposed on the phase shifting layer, said etch stop layer selected from the group consisting of Cr-containing films; and etching the phase shifting layer using the masking layer as a mask such that the etching stops on the etch stop layer. 13. The method according to claim 12, wherein said providing step includes providing an etch stop having a different etch chemistry from the substrate and from the phase shifting material wherein the etch stop layer has a plasma etch selectivity with respect to the phase shifting layer of greater than 3 to 1. 14. The method according to claim 12, further comprising: etching the etch stop layer. 15. The method according to claim 14, further comprising: removing the masking layer. 16. The method according to claim 12, wherein the masking layer comprises a resist layer disposed on a hard mask layer, and further comprising: performing a lithographic patterning and development of the resist layer; and etching the hard mask layer to form the masking layer. 17. The method according to claim 16, wherein said hard mask etch comprises etching the hard mask layer with a chlorine-based plasma. 18. The method according to claim 17, wherein said phase shifting material layer etching comprises etching the phase shifting material layer with a Halogen-based plasma. 19. The method according to claim 16, wherein said phase shifting material layer etching comprises etching the phase shifting material layer with a Halogen-based plasma. 20. The method according to claim 12, further comprising: etching said etch stop layer with a plasma etch that includes plasma chemistries that are selective to the substrate. 21. The method according to claim 20, wherein said etch stop layer comprises a Cr containing layer having a thickness of about 25 .ANG. to about 300 .ANG. and the plasma etch comprises a fluorine-based plasma etch. 22. An in-process phase shift mask structure, capable of shifting the phase of incident light and/or ultraviolet radiation 180 degrees, comprising: a transparent substrate; a non-opaque etch stop layer disposed on said substrate, said etch stop layer selected from the group consisting of Cr-containing films; a layer comprising a phase shifting material disposed on said etch stop layer; a hard mask layer disposed on said phase shift material layer; and a resist layer disposed on said hard mask layer. 23. The in-process phase shift mask according to claim 22, wherein the etch stop layer, the phase shifting layer, the hard mask layer, and the resist layer are patterned and have the same patterning. 24. The in-process phase shift mask according to claim 22, wherein said mask layer comprises Cr having a thickness of about 30 nm to about 100 nm. 25. The phase shift mask according to claim 22, wherein said mask layer is a polymer material having a thickness of about 100 nm to about 2000 nm. 26. An embedded attenuated phase shift mask, comprising: a transpa rent substrate; a patterned transmissive etch stop layer disposed on the substrate, said etch stop layer selected from the group consisting of Cr-containing films; and a patterned phase shifting material layer disposed on the etch stop layer, wherein the etch stop layer is etch resistant with respect an etchant for etching the phase shifting material layer, and wherein the phase shifting material is partially transmissive to imaging radiation. 27. An in-process phase shift mask structure, capable of shifting the phase of incident light and/or ultraviolet radiation 180 degrees, comprising: a transparent substrate; a non-opaque etch stop layer disposed on said substrate, said etch stop layer selected from the group consisting of Cr-containing films; a phase shifter layer comprising a phase shifting material disposed on said etch stop layer; and a layer disposed on said phase shifter material layer to define the etching boundaries of the phase shifter material layer, said layer selected from the group consisting of polymers and resist materials. chemistry of Room-Temperature Chloroaluminate Molten Salts at Graphitic and Nongraphitic Electrodes," Journal of Applied Electrochemistry, 26, (1996), pp. 1147-1160. Caja, Dunstan, Ryan, Katovic, "Application of Ionic Liquids as Electrolytes in Lithium Rechargeable Cells," Electrochemical Society Proceedings, V. 99-41, pp. 150-159. Cooper, O'Sullivan, "New Stable, Ambient-Temperature Molten Salts," pp. 386-396. Guidotti, Reinhardt, "Characterization of Low-Melting Electrolytes for Potential Geothermal Borehole Power Supplies: The LiBr-KBr-LiF Eutectic," 193rdMeeting of the Electrochemical Society, (1998) pp. 1-9. Guidotti, Reinhardt, "Characterization of the LiSi/CsBr-LiBr-KBr/FeS2System for Potential Use as a Geothermal Battery Source," 196thMeeting of the Electrochemical Society, (1999) pp. 1-13. Guidotti, Reinhardt, "Performance of Li-Alloy/Ag2CrO4Couples in Molten CsBr-LiBr-KBr Eutectic," 196th Meeting of the Electrochemical Society, (1999) pp. 1-11. Guidotti, Reinhardt, "Characterization of High-Voltage Cathodes in CsBr-LiBr-KBr Eutectic Electrolyte," 39thPower Source Conference, (2000) pp. 1-4. Guidotti, Reinhardt, "The Performance of Manganese Oxides as a Function of Temperature in Several Molten-Salt Systems," IBA 2000 Manganese Oxide Battery Symposium at Argonne National Lab, (2000) pp. 1-9.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (216)
Moore Dennis A. (Ferguson MO) Adams Max D. (St. Charles MO) Cacheris William P. (Florissant MO) White David H. (Ballwin MO) Periasamy Muthunadar P. (Chesterfield MO) Rajagopalan Raghavan (Maryland He, 19F magnetic resonance imaging agents which include a nitroxide moiety.
Lanza Gregory M. (Evanston IL) Onyuksel M. Hayat (LaGrange IL) Klegerman Melvin E. (Chicago IL) Vonesh Michael J. (Northbrook IL) McPherson David L. (Chicago IL), Acoustically reflective liposomes and methods to make and use same.
Lanza Gregory M. ; Alkan-Onyuksel M. Hayat ; Klegerman Melvin E. ; McPherson David D. ; Kane Bonnie J. ; Murer Sasha E., Acoustically reflective liposomes and methods to make and use the same.
Nicolau Yves-Claude (La Chapelle FRX) Le Pape Alain (Langeais FRX) Barot-Ciorbaru Rita (Fontenay-Aux-Roses FRX), Aerosol composition for in vivo imaging.
Dory Jacques (91 ; rue des Molveaux 77450 Coupvray-Esblay FRX), Apparatus for examining and localizing tumors using ultra sounds, comprising a device for localized hyperthermia treatme.
Heldebrant Charles M. (Arcadia CA) Crowe Kim C. (Northridge CA) Groveman George R. (Clairmont CA) Davis ; Jr. Charles H. (Mission Viejo CA), Apparatus for oxygenation of liquid state dissolved oxygen-carrying formulation.
Sekins K. Michael (San Diego CA) Shaffer Thomas H. (Lansdowne PA) Wolfson Marla R. (Wyndmoor PA), Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation.
Talish Roger J. (Fairfield NJ) Ryaby John P. (Essex Fells NJ) Scowen Kenneth J. (Springfield NJ) Urgovitch Kenneth J. (Clifton NJ), Apparatus for ultrasonic bone treatment.
Long ; Jr. David M. (El Cajon CA), Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal.
Jay Michael J. (Lexington KY) Ryo U. Yun (Lexington KY), Biodegradable, low biological toxicity radiographic contrast medium and method of x-ray imaging.
Hilmann Juergen (Berlin DEX) Hoffmann Rolf-Ruediger (Berlin DEX) Muetzel Wolfgang (Berlin DEX) Zimmermann Ingfried (Berlin DEX), Carrier liquid solutions for the production of gas microbubbles, preparation thereof, and use thereof as contrast medium.
Grinstaff Mark W. (Pasadena CA) Soon-Shiong Patrick (Los Angeles CA) Wong Michael (Champaign IL) Sandford Paul A. (Los Angeles CA) Suslick Kenneth S. (Champaign IL) Desai Neil P. (Los Angeles CA), Composition useful for in vivo delivery of biologics and methods employing same.
Higgins William A. (Gates Mills OH) Bretz John (Parma OH), Compositions containing basic metal salts and/or non-Newtonian colloidal disperse systems and vinyl aromatic containing.
Cerny David (Chula Vista CA) Mills Gary J. (San Diego CA) Westkaemper Peter J. (San Diego CA), Continuous sonication method for preparing protein encapsulated microbubbles.
Schneider David R. (Birmingham MI) Bis Kostaki G. (Troy MI), Contras agent having an imaging agent coupled to viable granulocytes for use in magnetic resonance imaging of abscess an.
Klaveness Jo (Olso NOX) Rongved Pl (Hellvik NOX) Stubberud Lars (Sodertalje SEX), Contrast agents, consisting of galactose particles and an amphilic carboxylic acid.
Weichselbaum Ralph R. (2031 N. Sedgwick Chicago IL 60616) Hallahan Dennis E. (5343 N. Moody Chicago IL 60630) Sukhatme Vikas P. (1511 E. 56th St. Chicago IL 60637) Kufe Donald W. (179 Grove St. Welle, Control of gene expression by ionizing radiation.
Lohrmann Rolf (La Jolla CA) Widder Kenneth J. (Rancho Santa Fe CA) Krishnan Ashwin M. (San Diego CA) Hong Dung K. (San Diego CA) Meng Jialun (San Diego CA), Emulsions as contrast agents and method of use.
Cullis Pieter R. (Vancouver CAX) Hope Michael J. (Vancouver CAX) Bally Marcel B. (Vancouver CAX), Extrusion technique for producing unilamellar vesicles.
Unger Evan C. (13365 E. Camino La Cebadilla Tucson AZ 85749) Wu Guanli (2602 W. Aiden St. Tucson AZ 85745), Gas filled liposomes and their use as ultrasonic contrast agents.
Unger Evan C. (13365 E. Camino La Cebadilla Tucson AZ 85749) Wu Guanli (2602 W. Aiden St. Tucson AZ 85745), Gas filled liposomes and their use as ultrasonic contrast agents.
Yan Feng (Carouge CHX) Schneider Michel (Troinex CHX) Brochot Jean (Feigeres FRX), Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method.
Cohen Smadar (Petach-Tickva MA ILX) Andrianov Alexander K. (Belmont MA) Wheatley Margaret (Media PA) Allcock Harry R. (State College PA) Langer Robert S. (Newton MA), Gas-filled polymeric microbubbles for ultrasound imaging.
Baldeschwieler John D. (Pasadena CA) Gamble Ronald C. (Pasadena CA) Mauk Marcia R. (Vancouver NJ CAX) Shen Tsung-Ying (Westfield NJ) Ponpipom Mitree M. (Branchburg NJ), Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances.
Axelsson Bengt I. (Genarp SEX) Brattsand Ralph L. (Lund SEX) Dahlbck Carl M. O. (Lund SEX) Kllstrm Leif A. (Sdra Sandby SEX) Trofast Jan W. (Lund SEX), Liposomes containing steroid esters.
Woodle Martin C. (Menlo Park CA) Martin Francis J. (San Francisco CA) Yau-Young Annie (Los Altos CA) Redemann Carl T. (Walnut Creek CA), Liposomes with enhanced circulation time.
Schneider Michel (Troinex CHX) Yan Feng (Geneva CHX) Grenier ; deceased Pascal (late of Ambilly FRX by Nadine Garcel ; legal heir ) Puginier Jerome (Le Chable-Beaumont FRX) Barrau Marie-Bernadette (G, Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the prepa.
Schneider Michel (Troinex CHX) Yan Feng (Genve CHX) Grenier ; deceased Pascal (late of Ambilly FRX by Nadine Garcel ; legal heir) Puginier Jrme (Le Chble-Beaumont FRX) Barrau Marie-Bernadette (Geneva, Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the prepa.
Cline Harvey E. (Schenectady NY) Ettinger Robert H. (Schenectady NY) Rohling Kenneth W. (Burnt Hills NY) Watkins Ronald D. (Niskayuna NY), Magnetic resonance guided focussed ultrasound surgery.
Albert Mitchell S. (Shoreham NY) Balamore Dilip (Shoreham NY) Cates ; Jr. Gordon D. (Skillman NJ) Driehuys Bastiaan (Bristol PA) Happer William (Princeton NJ) Saam Brian (Princeton NJ) Wishnia Arnold, Magnetic resonance imaging using hyperpolarized noble gases.
Desai Neil P. (Los Angeles CA) Soon-Shiong Patrick (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Grinstaff Mark W. (Pasadena CA) Suslick Kenneth S. (Champaign IL), Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell.
Baldeschwieler John D. (Pasadena CA) Gamble Ronald C. (Pasadena CA) Mauk Marcia R. (Vancouver CAX), Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species.
Radhakrishnan Ramachandran (Fremont CA) Mihalko Paul J. (Fremont CA) Abra Robert M. (San Francisco CA), Method and apparatus for administering dehydrated liposomes by inhalation.
Pierschbacher Michael D. (San Diego CA) Cheng Soan (San Diego CA) Craig William S. (San Diego CA) Tschopp Juerg F. (San Diego CA), Method and composition for treating thrombosis.
Arai Toshiyuki (26-46 Nishifukunokawa-cho Okazaki ; Sakyo-ku ; Kyoto 606 NY JPX) Gupte Pradeep M. (3 Larissa Ct. Tallman ; Monsey NY 10952) Lasker Sigmund E. (531 Main St. New York NY 10044), Method for introducing oxygen-17 into tissue for imaging in a magnetic resonance imaging system.
Lambert Karel J. ; Podell Sheila Benay ; Jablonski Edward G. ; Hulle Carl ; Hamilton Kenneth ; Lohrmann Rolf, Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas.
Grinstaff Mark W. (Pasadena CA) Desai Neil P. (Los Angeles CA) Suslick Kenneth S. (Champaign IL) Soon-Shiong Patrick (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Merideth Noma R. (Pacific Palis, Method for the preparation of fluorocarbon-containing polymeric shells for medical imaging.
Giddey Claude (Geneva CHX) Dove Georges (Carouge CHX), Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography.
D\Arrigo Joseph S. (Farmington CT), Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and the.
Bonsen Pieter (Los Altos CA) Wong Patrick S. (Kowloon CA HKX) Theeuwes Felix (Los Altos CA), Method of delivering drug with aid of effervescent activity generated in environment of use.
Lambert Karel J. (San Diego CA) Jablonski Edward G. (Escondido CA) Hulle Carl (San Diego CA), Method of making encapsulated gas microspheres useful as an ultrasonic imaging agent.
Unger Evan C. (Tucson AZ) Fritz Thomas A. (Tucson AZ) Matsunaga Terry (Tucson AZ) Ramaswami VaradaRajan (Tucson AZ) Yellowhair David (Tucson AZ) Wu Guanli (Tucson AZ), Method of preparing gas and gaseous precursor-filled microspheres.
Netting David I. (Springfield PA) Hertzenberg Elliot P. (Wilmington DE), Method of preparing modified hollow, largely spherical particles by spray drying.
Lencki Robert W. J. (1650 Lincoln Ave. ; Apt. 1101 Montreal ; Quebec CAX H3H 1H1) Neufeld Ronald J. (110 Westbank Ave. Pointe Claire ; Quebec CAX H9R 2X6) Spinney Trevor (3739 St. Dominique Montreal , Method of producing microspheres.
Widder Kenneth J. ; Levene Harold B. ; Bales Gary L., Method of ultrasonically quantitating myocardial perfusion using as intravenously injected tracer.
Levene Harold B. (San Diego CA) Villapando Elaine (San Diego CA) Barnhart James L. (Encinitas CA) Widder Kenneth J. (Del Mar CA), Method of ultrasound imaging of the gastrointestinal tract.
Keana John F. W. (Eugene OR), Methods for circumventing the problem of free radial reduction associated with the use of stable nitroxide free radicals.
Unger Evan C. (13365 E. Camino La Cebadilla Tucson AZ 85749), Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes.
Unger Evan C. (Tucson AZ) Fritz Thomas A. (Tucson AZ) Matsunaga Terry (Tucson AZ) Ramaswami VaradaRajan (Tucson AZ) Yellowhair David (Tucson AZ) Wu Guanli (Tucson AZ), Methods of preparing gas-filled liposomes.
Klaveness Jo (Oslo NLX) Rongved Pal (Hellvik NLX) Stubberud Lars (Sodertalje NLX), Microbubble-generating contrast agents for ultrasound and magnetic resonance imaging.
Bara Isabelle (Paris FRX) Mellul Myriam (L\Hay Les Roses FRX), New cosmetic or dermopharmaceutical compositions in the form of aqueous gels modified by the addition of expanded micros.
Grinstaff Mark W. (Pasadena CA) Desai Neil P. (Los Angeles CA) Suslick Kenneth S. (Champaign IL) Soon-Shiong Patrick (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Merideth Noma R. (Pacific Palis, Non-fluorinated polymeric shells for medical imaging.
Schweighardt Frank K. (Allentown PA) Rubertone Joseph A. (Coatesville PA), Perfluoro-crown ethers in fluorine magnetic resonance spectroscopy of biopsied tissue.
Dingle John T. (Whittlesford GB2) Gordon John L. (Cambridge GB2) Jones Geraint (Macclesfield GB2) Knight Clive G. (Huntingdon GB2) Lowe John S. (Wilmslow GB2), Pharmaceutical compositions.
Moore George G. I. (Afton MN) Flynn Richard M. (Mahtomedi MN) Guerra Miguel A. (Woodbury MN), Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use.
Moore George G. I. (Afton MN) Flynn Richard M. (Mahtomedi MN) Guerra Miguel A. (Woodbury MN), Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods of use.
Charpiot Brigitte (Nice FRX) Greiner Jacques (Nice FRX) Le Blanc Maurice (Nice FRX) Manfredi Alexandre (Nice FRX) Riess Jean (Falicon FRX) Zarif Leila (Nice FRX), Polyhydroxylated and highly fluorinated compounds, their preparation and their use as surfactants.
Mathiowitz Edith (Brookline MA) Langer Robert S. (Somerville MA) Warshawsky Abraham (Rehovot MA ILX) Edelman Elazar (Brookline MA), Polymer composite for controlled release or membrane formation.
Halliday Pieter S. J. (Randburg ZAX) Harris Allan J. (Knoppigslaagte ZAX), Process for the production of a cartridged explosive with entrapped bubbles.
Knight Jack V. (Houston TX) Gilbert Brian E. (Houston TX) Wilson Samuel Z. (Houston TX) Six Howard R. (East Stroudsborg PA) Wyde Philip R. (Houston TX), Small particle aerosol liposome and liposome-drug combinations for medical use.
Martin Francis J. (San Francisco CA) Woodle Martin C. (Menlo Park CA) Redemann Carl (Walnut Creek CA) Yau-Young Annie (Palo Alto CA), Solid tumor treatment method and composition.
Schutt Ernest G. (San Diego CA) Evitts David P. (La Jolla CA) Kinner Rene Alta (San Diego CA) Anderson Charles David (Lebanon NJ) Weers Jeffry G. (San Diego CA), Stabilized microbubble compositions.
Schneider Michel (Troinex CHX) Bichon Daniel (Montpellier FRX) Bussat Philippe (Collonge S/Saleve FRX) Puginier Jerome (Le Chable-Beaumont FRX) Hybl-Sutherland Eva (Wiesbaden DEX), Stable microbubbles suspensions injectable into living organisms.
Schneider Michel (Troinex CHX) Bichon Daniel (Montpellier FRX) Bussat Philippe (Collonges S/Saleve FRX) Puginier Jerome (Le Chable-Beaumont FRX) Hybl-Sutherland Eva (Wiesbaden DEX), Stable microbubbles suspensions injectable into living organisms.
Schneider Michel (Troinex CHX) Bichon Daniel (Montpellier FRX) Bussat Philippe (Collonges S/Saleve FRX) Puginier Jerome (Le Chable-Beaumont FRX) Hybl-Sutherland Eva (Wiesbaden DEX), Stable microbubbles suspensions injectable into living organisms.
Schneider Michel (Troinex CHX) Bichon Daniel (Montpellier FRX) Bussat Philippe (Collonges S/Saleve FRX) Puginier Jerome (Le Chable-Beaumont FRX) Hybl-Sutherland Eva (Wiesbaden DEX), Stable microbubbles suspensions injectable into living organisms.
Schneider Michel (Troinex CHX) Bichon Daniel (Montpellier FRX) Bussat Philippe (Collonges S/Saleve FRX) Puginier Jerome (Le Chable-Beaumont FRX) Hybl-Sutherland Eva (Wiesbaden DEX), Stable microbubbles suspensions injectable into living organisms.
Wong Sui-Ming (Collegeville PA) Newington Ian M. (Hazlemere GB2) Liversidge Elaine M. (West Chester PA) McIntire Gregory L. (West Chester PA) Pitt Alan R. (Sandridge GBX) Shaw Jack M. (Aberdeen MD), Sulfated nonionic block copolymer surfactants as stabilizer coatings for nanoparticle compositions.
D\Arrigo Joseph S. (23A Brickyard Rd. Farmington CT 06032), Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures.
Unger Evan C. (Tucson AZ) Fritz Thomas A. (Tucson AZ) Matsunaga Terry (Tucson AZ) Ramaswami VaradaRajan (Tucson AZ) Yellowhair David (Tucson AZ) Wu Guanli (Tucson AZ), Therapeutic delivery systems related applications.
Popescu Mircea (Plainsboro NJ) Swenson Christine E. (Plainsboro NJ) Johnson Sterling C. (Skillman NJ) Lenk Robert P. (Lambertville NJ), Therapeutic treatment by intramammary infusion.
Reinhardt Michael (Berlin DEX) Fritzsch Thomas (Berlin DEX) Heldmann Dieter (Berlin DEX) Siegert Joachim (Berlin DEX), Ultrasonic contrast agents for color Doppler imaging.
Erbel Raimund (Mainz DEX) Zotz Rainer (Mainz DEX) Krone Volker (Flrsheim DEX) Magerstdt Michael (Hofheim am Taunus DEX) Walch Axel (Frankfurt am Main DEX), Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents.
Erbel Raimund (Mainz DEX) Zotz Rainer (Mainz DEX) Krone Volker (Flrsheim DEX) Magerstdt Michael (Hofheim am Taunus DEX) Walch Axel (Frankfurt am Main DEX), Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents.
Erbel Raimund (Mainz) Zotz Rainer (Mainz) Krone Volker (Flrsheim) Magerstdt Michael (Hofheim am Tanus) Walch Axel (Frankfurt am Main DEX), Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents.
Rasor Ned S. (Cupertino CA) Hilmann Jurgen (Berlin DEX) Lange Lothar (Berlin DEX) Fritzsch Thomas (Berlin DEX) Siegert Joachim (Berlin DEX) Zimmermann Ingfried (Weiler DEX), Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use ther.
Vaezy, Shahram; Nguyen, Thuc Nghi; Zderic, Vesna; Foley, Jessica, Acoustic coupler using an independent water pillow with circulation for cooling a transducer.
Pettegrew, Jay W.; McClure, Richard J.; Panchalingam, Kanagasabai; Day, Billy W., Compounds, compositions and methods for medical imaging of neuropsychiatric disorders.
Crum, Lawrence A.; Kaczkowski, Peter J.; Mitchell, Stuart B.; Bailey, Michael R., Method and apparatus for preparing organs and tissues for laparoscopic surgery.
Robinson, Simon P.; Siegler, Robert W.; Nguyen, Nhung Tuyet; Onthank, David C.; Anklekar, Tarakeshwar Vishwanath; Van Kirk, Charles Chester, Methods for making ultrasound contrast agents.
Robinson, Simon P.; Siegler, Robert W.; Nguyen, Nhung Tuyet; Onthank, David C.; Anklekar, Tarakeshwar Vishwanath; Van Kirk, Charles Chester, Methods for making ultrasound contrast agents.
Robinson, Simon P.; Siegler, Robert W.; Nguyen, Nhung Tuyet; Onthank, David C.; Anklekar, Tarakeshwar Vishwanath; Van Kirk, Charles Chester, Methods for making ultrasound contrast agents.
Vaezy, Shahram; Chan, Arthur H.; Fujimoto, Victor Y.; Moore, Donald E.; Martin, Roy W., Methods for using high intensity focused ultrasound and associated systems and devices.
Gulati, Sandeep; Ruchti, Timothy L.; Smith, John L.; Van Antwerp, William, Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing.
Gulati, Sandeep; Ruchti, Timothy L.; Van Antwerp, William; Smith, John L., Systems and methods for blood glucose and other analyte detection and measurement using collision computing.
Gulati, Sandeep; Ruchti, Timothy L.; Van Antwerp, William; Smith, John L., Systems and methods for collision computing for detection and noninvasive measurement of blood glucose and other substances and events.
Gulati, Sandeep; Ruchti, Timothy L.; Smith, John L.; Van Antwerp, William, Systems and methods for control of illumination or radiation collection for blood glucose and other analyte detection and measurement using collision computing.
Gulati, Sandeep; Ruchti, Timothy L.; Van Antwerp, William; Smith, John L., Systems and methods for generating and using projector curve sets for universal calibration for noninvasive blood glucose and other measurements.
Gulati, Sandeep; Ruchti, Timothy L.; Smith, John L., Systems and methods for measurement of heart rate and other heart-related characteristics from photoplethysmographic (PPG) signals using collision computing.
Gulati, Sandeep; Ruchti, Timothy L.; Antwerp, William V.; Smith, John L., Systems and methods for noninvasive blood glucose and other analyte detection and measurement using collision computing.
Gulati, Sandeep; Ruchti, Timothy L.; Van Antwerp, William; Smith, John L., Systems and methods for noninvasive blood glucose and other analyte detection and measurement using collision computing.
Gulati, Sandeep; Ruchti, Timothy L., Systems and methods for synthesis of zyotons for use in collision computing for noninvasive blood glucose and other measurements.
Vaezy, Shahram; Martin, Roy W.; Carter, Stephen J.; Crum, Lawrence A., Use of contrast agents to increase the effectiveness of high intensity focused ultrasound therapy.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.