University of Louisville Research Foundation, Inc.
대리인 / 주소
Schwegman, Lundberg, Woessner & Kluth, P.A.
인용정보
피인용 횟수 :
1인용 특허 :
9
초록▼
Antimicrobial compounds of formula I are disclosed: R1--X--R2 wherein X is a group comprising of from about 4 to about 10 amino acids, wherein at least one of the amide (--CONH--) linkages is replaced by --CRaRaRbNRc--; Ra,Rb,and Rcare each independently hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (
Antimicrobial compounds of formula I are disclosed: R1--X--R2 wherein X is a group comprising of from about 4 to about 10 amino acids, wherein at least one of the amide (--CONH--) linkages is replaced by --CRaRaRbNRc--; Ra,Rb,and Rcare each independently hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C8)cycloalkyl, (C1-C6)alkoxycarbonyl, aryl, or heterocycle; and R1and R2are each independently hydrogen, a saccharide, a lipid, a solubilizing agent, or a suitable protecting group; or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising such compounds or salts, and methods of using such compounds or salts to treat a bacterial infection.
대표청구항▼
Antimicrobial compounds of formula I are disclosed: R1--X--R2 wherein X is a group comprising of from about 4 to about 10 amino acids, wherein at least one of the amide (--CONH--) linkages is replaced by --CRaRaRbNRc--; Ra,Rb,and Rcare each independently hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (
Antimicrobial compounds of formula I are disclosed: R1--X--R2 wherein X is a group comprising of from about 4 to about 10 amino acids, wherein at least one of the amide (--CONH--) linkages is replaced by --CRaRaRbNRc--; Ra,Rb,and Rcare each independently hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C8)cycloalkyl, (C1-C6)alkoxycarbonyl, aryl, or heterocycle; and R1and R2are each independently hydrogen, a saccharide, a lipid, a solubilizing agent, or a suitable protecting group; or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising such compounds or salts, and methods of using such compounds or salts to treat a bacterial infection. w York. Erling A, Methodological considerations in the assessment of health-related quality of life in children, Acta Paediatr Suppl 1999, pp. 106-107, vol. 428, Scandinavian Univ. Press. Savage Mo et al., Growth in Crohn's disease, Acta Paediatr Suppl 1999, pp. 89-92, vol. 428, Scandinavian Univ. Press. Parks JS et al., Growth Hormone Deficiency, Molecular Endocrinology Basic Concepts & Clinical Correlations 1995, Ch. 29, pp. 473-490, Raven Press, Ltd., New York. Thorner MO et al., Extrahypothalamic Browth-Hormone-Releasing Factor (GRF) Secretion Is a Rare Cause of Acromegaly: Plasma GRF Levels in 177 Acromegalic Patients, Journal of Clinical Endocrinology & Metabolism 1984, pp. 846-849, vol. 59, No. 5, The Endocrine Society, USA. Corpas E et al., Continuous Subcutaneous Infusions of Growth Hormone (GH) Releasing Hormone 1-44 for 14 Days Increase GH and Insulin-Like Growth Factor-I Levels in Old Men; Journal of Clinical Endocrinology & Metabolism, 1993, pp. 134-138, vol. 76, No. 1, The Endocrine Society, USA. Esch FS et al., Characterization of a 40 residue peptide from a human pancreatic tumor with growth hormone releasing activity, Biochemical & Biophysical Research Communications, Nov. 16, 1982, pp. 152-158, vol. 109, No. 1, Academic Press. Frohman LA et al., Metabolic Clearance & Plasma Disappearance Rates of Human Pancreatic Tumor Growth Hormone Releasing Factor in Man, J. Clin. Invest., May 1984, pp. 1304-1311, vol. 73, The American Society for Clinical Investigation, Inc. Corpas E et al., Human growth hormone & human aging, Endocrine Reviews, 1993, pp. 20-39, vol. 14, No. 1, The Endocrine Society, USA. Campbell RM et al., GRF analogs & fragments: correlation between receptor binding, activity & structure, Peptides, 1991, pp. 569-574, vol. 12, Pergamon Press plc, USA. Martin RA et al., Dipeptidyl peptidase IV (DPP-IV) from pig kidney cleaves analogs of bovine growth hormone-releasing factor (bGRF) modified at position 2 with Ser, Thr or Val. extended DPP-IV substrate specificity?, Biochimica et Bioshysica Acta, 1993, pp. 252-260, vol. 1164, Elsevier Science Publishers BV. SU C-M et al., In vitro stability of growth hormone releasing factor (GRF) analogs in porcine plasma, Horm.metab.Res, 1991, pp. 15-21, vol. 23, Georg Thieme Verlag Stuttgart NY. Kubiak TM et al., In vitro metabolic degradation of a bovine growth hormone-releasing factor analog LEU27-bGRF(1-29)NH2in bovine & porcine plasma, Drug Metabolism & Disposition 1989, pp. 393-397, vol. 17, No. 4, The American Society for Pharmacology & Experimental Therapeutics, USA. Frohman MA et al., Cloning & character
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (9)
Geria Navin M. (Warren NJ), Antiinflammatory skin moisturizing composition and method of preparing same.
Lehrer Robert I. (Santa Monica CA) Selsted Michael E. (Los Angeles CA) Ganz Tomas (Los Angeles CA), Cationic oligopeptides having microbicidal activity.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.