Compositions and methods for mucosal delivery
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/495
A61K-009/00
A61K-009/14
A61K-009/70
A61K-031/24
A61K-031/44
A61K-031/50
A61K-031/505
A61K-031/56
출원번호
US-0434878
(1999-11-05)
발명자
/ 주소
Chen, Li-Lan H.
Pfister, William R.
Renn, Donald W.
Buranachokpaisan, Thitiwan
Osborne, James
Tan, Hock Seng
Tao, Li
출원인 / 주소
Lavipharm Laboratories Inc.
대리인 / 주소
Dechert
인용정보
피인용 횟수 :
93인용 특허 :
60
초록▼
Mucosal surface-coat-forming film dosage units containing a water-soluble hydrocolloid, an effective dose of an active agent and a mucosal adhesion enhancer; wherein the active agent is encapsulated within a polymer which is chemically or physically distinct from the hydocolloid; wherein the mucosal
Mucosal surface-coat-forming film dosage units containing a water-soluble hydrocolloid, an effective dose of an active agent and a mucosal adhesion enhancer; wherein the active agent is encapsulated within a polymer which is chemically or physically distinct from the hydocolloid; wherein the mucosal adhesion enhancer is a starch graft copolymer; wherein the film exhibits a dry tack value of less than 3.5 g, a wet tack of greater than 35 g, a gelation temperature that is greater than 70° C. for a 2% polymer solution, a dry film thickness of less than 20 mil, a water content of 0.5 to 10%, a tensile strength greater than 1500 psi, a modulus in the range of 35,000 to 300,000 psi, a % elongation of less than 20%, a tear probagation resistance of 0.001 to 1 N, and a dissolution time in the range of 1 to 600 seconds upon application to an oral mucosal surface.
대표청구항▼
Mucosal surface-coat-forming film dosage units containing a water-soluble hydrocolloid, an effective dose of an active agent and a mucosal adhesion enhancer; wherein the active agent is encapsulated within a polymer which is chemically or physically distinct from the hydocolloid; wherein the mucosal
Mucosal surface-coat-forming film dosage units containing a water-soluble hydrocolloid, an effective dose of an active agent and a mucosal adhesion enhancer; wherein the active agent is encapsulated within a polymer which is chemically or physically distinct from the hydocolloid; wherein the mucosal adhesion enhancer is a starch graft copolymer; wherein the film exhibits a dry tack value of less than 3.5 g, a wet tack of greater than 35 g, a gelation temperature that is greater than 70° C. for a 2% polymer solution, a dry film thickness of less than 20 mil, a water content of 0.5 to 10%, a tensile strength greater than 1500 psi, a modulus in the range of 35,000 to 300,000 psi, a % elongation of less than 20%, a tear probagation resistance of 0.001 to 1 N, and a dissolution time in the range of 1 to 600 seconds upon application to an oral mucosal surface. al infarction, angina, stroke, pulmonary embolism, transient ischemic attack, deep vein thrombosis, thrombotic re-occlusion subsequent to a coronary intervention procedure, heart surgery or vascular surgery, peripheral vascular thrombosis, Syndrome X, heart failure, and a disorder in which a narrowing of at least one coronary artery occurs. 16. A method of inhibiting or reducing platelet activation comprising contacting at least one SSRI with platelets in an amount sufficient to inhibit or reduce the platelet activation, wherein the SSRI is selected from the group consisting of venlafaxine, a venlafaxine metabolite, mirtazapine, a mirtazapine metabolite, buspirone, a buspirone metabolite, trazodone, a trazodone metabolite, nefazadone, a nefazadone metabolite, clomipramine, a clomipramine metabolite, imipramine, a imipramine metabolite, nortriptyline, a nortriptyline metabolite, mianserine, a mianserine metabolite, duloxetine, a duloxetine metabolite, dapoxetine, a dapoxetine me
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