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A patch for iontophoretic transdermal application of a medicant, where the patch includes a border portion disposed about an aperture. The border portion can include a first polarity electrode in electrical communication with the medicant, and a second border portion including a second electrode hav

A patch for iontophoretic transdermal application of a medicant, where the patch includes a border portion disposed about an aperture. The border portion can include a first polarity electrode in electrical communication with the medicant, and a second border portion including a second electrode having a second polarity opposite the first electrode polarity. One patch has a liftable cover, preferably a transparent and non-adherent cover, disposed over the patch aperture. A preferred medicant for inclusion in the present invention is a local anesthetic or analgesic. Other medicants such as anti-inflammatory agents or anti-infective agents may be used to locally reduce inflammation, contain infection, and alleviate pain. The present invention can allow performing a field block anesthetic about an epidermal target site. The present invention can allow observing a target or treatment site while leaving the patch in place. An invasive medical procedure can be performed through the patch aperture, and pre-operative and post-operative procedures can also be performed through the patch aperture.

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A patch for iontophoretic transdermal application of a medicant, where the patch includes a border portion disposed about an aperture. The border portion can include a first polarity electrode in electrical communication with the medicant, and a second border portion including a second electrode hav

A patch for iontophoretic transdermal application of a medicant, where the patch includes a border portion disposed about an aperture. The border portion can include a first polarity electrode in electrical communication with the medicant, and a second border portion including a second electrode having a second polarity opposite the first electrode polarity. One patch has a liftable cover, preferably a transparent and non-adherent cover, disposed over the patch aperture. A preferred medicant for inclusion in the present invention is a local anesthetic or analgesic. Other medicants such as anti-inflammatory agents or anti-infective agents may be used to locally reduce inflammation, contain infection, and alleviate pain. The present invention can allow performing a field block anesthetic about an epidermal target site. The present invention can allow observing a target or treatment site while leaving the patch in place. An invasive medical procedure can be performed through the patch aperture, and pre-operative and post-operative procedures can also be performed through the patch aperture. uid against a carrier signal, thereby yielding a modulated carrier signal; and an amplifier for amplifying the modulated carrier signal. 11. The analyte monitoring device of claim 10, wherein the modulator and amplifier comprise a single integrated circuit. 12. The analyte monitoring device of claim 5, further comprising: a battery mounted upon the substrate and operably coupled to the integrated circuit for providing power to the integrated circuit. 13. The analyte monitoring device of claim 5, wherein the transmitter is configured and arranged to mate with a battery, so as to provide an electrical path for provision of power to the integrated circuit. 14. A method of detecting a level of an analyte in a bodily fluid, comprising: inserting a portion of a sensor transcutaneously, the sensor comprising a substrate, a transmitter and a working electrode, the substrate having the transmitter and the working electrode disposed upon it, the working electrode being configured and arranged to produce a signal representative of a level of an analyte in a bodily fluid; holding a portion of the sensor in a fixed orientation relative to skin through which the portion of the sensor is trancutaneously inserted; and transmitting a signal representing the level of the analyte to a receiver. 15. The method of claim 14, wherein inserting a portion of the sensor transcutaneously comprises inserting a portion of a flexible sensor transcutaneously. 16. The method of claim 14, wherein inserting a portion of the sensor transcutaneously comprises inserting a portion of the sensor, wherein the sensor further comprises an analyte responsive member disposed upon the working electrode. 17. The method of claim 14, wherein inserting a portion of the sensor transcutaneously comprises inserting a portion of the sensor, wherein the working electrode, which partially comprises the sensor, is configured and arranged to produce a signal representative of glucose level in a bodily fluid. 18. The method of claim 14, wherein holding a portion of the sensor in a fixed orientation comprises adhering a portion of the sensor to the skin. 19. The method of claim 14, wherein holding a portion of the sensor in a fixed orientation comprises suturing a portion of the sensor with the skin. 20. The method of claim 14, wherein holding a portion of the sensor in a fixed orientation comprises strapping a portion of the sensor to the skin. 21. The method of claim 14, wherein periodically transmitting a signal representing the level of the analyte comprises transmitting the signal representing the level of the analyte at least once every hour. 22. The method of claim 14, further comprising withdrawing the substrate after a period of use of one day or more. 23. The method of claim 14, further comprising mating a battery with the sensor, thereby providing power to the transmitter. 24. The method of claim 23, wherein mating a battery with the sensor comprises mating a housing to the substrate, the housing at least partially enclosing the battery. 25. An analyte monitoring device comprising: an electrochemical sensor, at least a portion of which is adapted for implantation and intimate contact with bodily fluid, the electrochemical sensor producing a signal representative of an analyte level of the bodily fluid; and a transmitter coupled to the electrochemical sensor for transmitting a signal that is representative of the level of the analyte in the bodily fluid, the transmitter being configured and arranged to employ a set of spreading codes to facilitate transmission of the signal. 26. The analyte monitoring device of claim 25, wherein the electrochemical sensor comprises a flexible substrate. 27. The analyte monitoring device of claim 25, wherein the electrochemical sensor comprises a working electrode with an analyte responsive enzyme disposed upon at least a portion of the working electrode. 28. The analyte monitoring device of claim 25, wherein the electroc hemical sensor is configured and arranged to produce a signal representative of glucose level in the bodily fluid. 29. The analyte monitoring device of claim 25, wherein the transmitter is further configured and arranged to transmit a second identifying signal. 30. The analyte monitoring device of claim 25, wherein the transmitter is configured and arranged to employ a processing gain sufficient to permit at least two transmitters to discernibly transmit in the same region. 31. The analyte monitoring device of claim 30, wherein the transmitter is configured and arranged to employ a processing gain sufficient to pen-nit at least four transmitters to discernibly transmit in the same region. 32. The analyte monitoring device of claim 31, wherein the transmitter is configured and arranged to employ a processing gain sufficient to permit at least eight transmitters to discernibly transmit in the same region. 33. The analyte monitoring device of claim 32, wherein the transmitter is configured and arranged to employ a processing gain sufficient to permit at least sixteen transmitters to discernibly transmit in the same region. 34. A method of manufacturing a population of analyte monitoring devices, each analyte monitoring device comprising an electrochemical sensor and a transmitter, the method comprising: assigning a first set of spreading codes to a first transmitter within a first subset of the population of analyte monitoring devices; assigning a second set of spreading codes to a second transmitter within a second subset of the population of analyte monitoring devices, wherein the second set of spreading codes excludes the first set of spreading codes; and coupling the first transmitter to the electrochemical sensor, so as to provide the first transmitter with a conductive path to receive from the electrochemical sensor a signal representative of an analyte level in a bodily fluid. 35. The method of claim 34, wherein coupling the transmitter to the electrochemical sensor comprises disposing the transmitter upon the electrochemical sensor. 36. The method of claim 35, wherein disposing the transmitter upon the electrochemical sensor comprises disposing the transmitter upon a flexible substrate of the electrical sensor. 37. A method of communicating a digital signal representing a level of an analyte in a bodily fluid, the method comprising: assembling a plurality of data words into a data message, at least one of the data words containing data derived from the digital signal representing a level of an analyte in a bodily fluid, each of the data words comprising a set of bits, wherein for at least two of the data words, the set of bits are organized into a set of data bits and a set of error correction bits; and transmitting the data message, such that the bits comprising one of the plurality of data words assembled into the data message are not transmitted contiguously. 38. The method of claim 37, wherein assembling the plurality of data words into the data message comprises assembling the plurality of data words into the data message, wherein for each of the data words, the set of bits are organized into a set of data bits and a set of error correction bits. 39. The method of claim 37, further comprising: collecting an analog signal representing a level of an analyte in a bodily fluid; converting the analog signal into a digital signal representing a level of an analyte in a bodily fluid. 40. The method of claim 39, wherein transmitting the data message comprises transmitting a first bit of each data word assembled into the data message, followed by a second bit of each data word assembled into the data message, proceeding on to transmit a subsequent bit of each data word assembled into the data message until the entire data message has been transmitted. 41. An analyte monitoring device comprising: an electrochemical sensor, at least a portion of which is adapted for implantation and intimate contact with b