IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0028956
(2001-12-27)
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발명자
/ 주소 |
- Young, Eric P.
- Reynolds, John
- Curran, Mathew
- Gast, Danny
- Wurts, Joseph
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출원인 / 주소 |
- Lockheed Martin Corporation
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대리인 / 주소 |
Bracewell & Patterson, L.L.P.
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인용정보 |
피인용 횟수 :
8 인용 특허 :
0 |
초록
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A parachute system for a miniature aircraft having a storable parachute mounted on an upper surface of the aircraft. The system includes a canopy having a stored condition and an expanded condition. A plurality of suspension lines have first ends connected to the periphery of the canopy and second e
A parachute system for a miniature aircraft having a storable parachute mounted on an upper surface of the aircraft. The system includes a canopy having a stored condition and an expanded condition. A plurality of suspension lines have first ends connected to the periphery of the canopy and second ends connected to an elastic member. First and second risers are connected by their first ends to the upper surface of the aircraft between the front end and center of gravity on either side of the longitudinal axis and by their second ends to the elastic member. A restraint system releasably restrains the parachute in the stored condition on the top surface of the aircraft; and a release system coupled to the restraint system releases the parachute upon command such that aerodynamic forces will cause the parachute to open.
대표청구항
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A parachute system for a miniature aircraft having a storable parachute mounted on an upper surface of the aircraft. The system includes a canopy having a stored condition and an expanded condition. A plurality of suspension lines have first ends connected to the periphery of the canopy and second e
A parachute system for a miniature aircraft having a storable parachute mounted on an upper surface of the aircraft. The system includes a canopy having a stored condition and an expanded condition. A plurality of suspension lines have first ends connected to the periphery of the canopy and second ends connected to an elastic member. First and second risers are connected by their first ends to the upper surface of the aircraft between the front end and center of gravity on either side of the longitudinal axis and by their second ends to the elastic member. A restraint system releasably restrains the parachute in the stored condition on the top surface of the aircraft; and a release system coupled to the restraint system releases the parachute upon command such that aerodynamic forces will cause the parachute to open. teroaryl; R15is chosen from hydrogen, alkyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, substituted alkyl, substituted aryl, substituted alkylaryl, substituted heteroaryl, and substituted alkylheteroaryl; R16is chosen from alkoxy, amino, alkylamino, dialkylamino, N-heterocyclyl and substituted N-heterocyclyl; under conditions suitable for said compound to bind to said KSP kinesin; (b) adding a candidate agent under conditions suitable for said agent to bind to said KSP kinesin, thereby displacing at least a portion of said compound that had been bound to said KSP kinesin; and (c) determining the binding of said agent to said KSP by monitoring the amount of said compound either bound to said KSP or displaced therefrom. 2. The method of claim 1, wherein said label directly or indirectly provides a detectable signal. 3. The method of claim 1, wherein said label is selected from the group consisting of a radioisotope, a fluorescent group, an enzyme, a magnetic particle group, a specific binding molecule and a chemiluminescent group. 4. The method of claim 1, wherein, in step (a), said conditions suitable for said compound to bind to said KSP comprise incubating said compound with said kinesin. 5. The method of claim 4, wherein said incubation is performed at a temperature of between 4 and 40° C. 6. The method of claim 4, wherein after incubating said compound with said kinesin, said method further comprises washing to remove excess compound. 7. The method of claim 1, wherein, in step (b), said conditions suitable for said agent to bind to said KSP kinesin comprise incubating said agent with said kinesin. 8. The method of claim 1, wherein the screening occurs in the presence of microtubules. 9. A method of screening for compounds that bind to KSP kinesin comprising the steps of: (a) combining a KSP kinesin with a labeled candidate agent under conditions suitable for said agent to bind to said KSP kinesin; and (b) adding a compound under conditions suitable for said compound to bind to said KSP kinesin and displace said agent therefrom, wherein said compound is chosen from the group consisting of: wherein: R1is chosen from hydrogen, alkyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, substituted alkyl, substituted aryl, substituted alkylaryl, substituted heteroaryl, and substituted alkylheteroaryl; R2and R2' are independently chosen from hydrogen, alkyl, oxaalkyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, substituted alkyl, substituted aryl, substituted alkylaryl, substituted heteroaryl, and substituted alkylheteroaryl; or R2and R2' taken together form a 3- to 7-membered ring; R3is chosen from hydrogen, alkyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, substituted alkyl, substituted aryl, substituted alkylaryl, substituted heteroaryl, substituted alkylheteroaryl, oxaalkyl, oxaalkylaryl, substituted oxaalkylaryl, R15O-- and R15--NH--; R3'is chosen from hydrogen, alkyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, substituted alkyl, substituted aryl, substituted alkylaryl, substituted heteroaryl, substituted alkylheteroaryl and R15--NH--; R3"is chosen from alkyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, substituted alkyl, substituted aryl, substituted alkylaryl, substituted heteroaryl, and substituted alkylheteroaryl; R4is chosen from hydrogen, alkyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, substituted alkyl, substituted aryl, substituted alkylaryl, substituted heteroaryl, substituted alkylheteroaryl, and R16-alkylene-; R5,R6,R7and R8are independently chosen from hydrogen, alkyl, alkoxy, halogen, fluoroalkyl, nitro, dialkylamino, alkylsulfonyl, alkylsulfonamido, sulfonamidoalkyl, sulfonamidoaryl, alkylthio, carboxyalkyl, carboxamido, aminocarbonyl, aryl and heteroaryl; R15is chosen from hydrogen, alkyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, substituted alkyl, substituted aryl, substituted alkylaryl, substituted heteroaryl, and substituted alkylheteroaryl; R16is chosen from alkoxy, amino, alkylamino, dialkylamino, N-heterocyclyl and substituted N-heterocyclyl; and (c) determining the binding of said agent to said KSP kinesin by monitoring the amount of labeled compound either bound to KSP or displaced therefrom. 10. The method of claim 9, wherein said label directly or indirectly provides a detectable signal. 11. The method of claim 10, wherein said label is selected from the group consisting of a radioisotope, a fluorescent group, an enzyme, a magnetic particle group, a specific binding molecule and a chemiluminescent group. 12. The method of claim 9, wherein, in step (a), said conditions suitable for said agent to bind to said KSP comprise incubating said agent with said kinesin. 13. The method of claim 12, wherein said incubation is performed at a temperature of between 4 and 40° C. 14. The method of claim 12, wherein after incubating said agent with said kinesin, said method further comprises washing to remove excess agent. 15. The method of claim 9, wherein, in step (b), said conditions suitable for said compound to bind to said KSP comprise incubating said compound with said kinesin. 16. The method of claim 15 wherein said incubation is performed at a temperature of between 4 and 40° C. 17. The method of claim 9, wherein the screening occurs in the presence of microtubules. 18. A method according to claims 1 or 9, wherein said compound has a formula: 19. A method according to claim 18 wherein R1is chosen from hydrogen, lower alkyl, substituted lower alkyl, benzyl, substituted benzyl, phenyl, naphthyl and substituted phenyl. 20. A method according to claim 19 wherein R1is chosen from hydrogen, ethyl, propyl, methoxyethyl, naphthyl, phenyl, bromophenyl, chlorophenyl, methoxyphenyl, ethoxyphenyl, tolyl, dimethylphenyl, chorofluorophenyl, methylchlorophenyl, ethylphenyl, phenethyl, benzyl, chlorobenzyl, methylbenzyl, methoxybenzyl, tetrahydrofuranylmethyl and (ethoxycarbonyl)ethyl. 21. A method according to claim 18 wherein R2is chosen from hydrogen, lower alkyl and substituted lower alkyl, and R2' is hydrogen. 22. A method according to claim 21 wherein R2is chosen from hydrogen, methyl, ethyl, propyl, methylthioethyl, aminobutyl, (CBZ)aminobutyl, cyclohexylmethyl, benzyloxymethyl, methylsulfinylethyl, methylsulfinylmethyl, hydroxymethyl, benzyl and indolylmethyl. 23. A method according to claim 18, wherein R3is chosen from C1-C13alkyl; substituted lower alkyl; phenyl; naphthyl; phenyl substituted with one or more halo, lower alkyl, loweralkoxy, nitro, carboxy, methylenedioxy or trifluoromethyl; biphenylyl; benzyl; phenoxymethyl; halophenoxymethyl; phenylvinyl; heteroaryl; heteroaryl substituted with lower alkyl; and benzyloxymethyl. 24. A method according to claim 23 wherein R3is chosen from ethyl, propyl, chloropropyl, butoxy, heptyl, butyl, octyl, tridecanyl, (ethoxycarbonyl)ethyl, dimethylaminoethyl, dimethylaminomethyl, phenyl, naphthyl, halophenyl, dihalophenyl, cyanophenyl, halo(trifluoromethyl)phenyl, chlorophenoxymethyl, methoxyphenyl, carboxyphenyl, ethylphenyl, tolyl, biphenylyl, methylenedioxyphenyl, methylsulfonylphenyl, methoxychlorophenyl, chloronaphthyl, methylhalophenyl, trifluoromethylphenyl, butylphenyl, pentylphenyl, methylnitrophenyl, phenoxymethyl, dimethoxyphenyl, phenylvinyl, nitrochlorophenyl, nitrophenyl, dinitrophenyl, bis(trifluoromethyl)phenyl, benzyloxymethyl, benzyl, furanyl, benzofuranyl, pyridinyl, indolyl, methylpyridinyl, quinolinyl, picolinyl, pyrazolyl, and imidazolyl. 25. A method according to claim 18 wherein R3is R15--NH-- and R15is chosen from lower alkyl; cyclohexyl; phenyl; and phenyl substitut
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