초록 ▼

Methods, compositions and articles for blocking transepithelial transmission of HIV with ICAM-1 angonist/antagonists are provided. The ICAM-1 agonist/antagonists block viral transmission at the site of exposure to the virus. Blocking viral transmission does not require blocking the binding of ICAM-1

Methods, compositions and articles for blocking transepithelial transmission of HIV with ICAM-1 angonist/antagonists are provided. The ICAM-1 agonist/antagonists block viral transmission at the site of exposure to the virus. Blocking viral transmission does not require blocking the binding of ICAM-1 to LFA-1. The ICAM-1 agonist/antagonists may be applied to mucosal surfaces, on or in contraceptive devices or in oral solutions such as breast milk supplements and infant formula.

대표청구항 ▼

Methods, compositions and articles for blocking transepithelial transmission of HIV with ICAM-1 angonist/antagonists are provided. The ICAM-1 agonist/antagonists block viral transmission at the site of exposure to the virus. Blocking viral transmission does not require blocking the binding of ICAM-1

Methods, compositions and articles for blocking transepithelial transmission of HIV with ICAM-1 angonist/antagonists are provided. The ICAM-1 agonist/antagonists block viral transmission at the site of exposure to the virus. Blocking viral transmission does not require blocking the binding of ICAM-1 to LFA-1. The ICAM-1 agonist/antagonists may be applied to mucosal surfaces, on or in contraceptive devices or in oral solutions such as breast milk supplements and infant formula. M., et al. (1991) "Control of dorso-ventral pattern in vertebrate neural development induction and polarizing properties of the floor plate." Development 113 (Suppl. 2): 105-122. Placzek, M., et al. (1992) "Induction of floor plate differentiation by contact-dependent, homeogenetic signals." Development 117:205-218. Roelink, H. and Nusse, R. (1991) "Expression of two members of the Wnt family during mouse development: restricted temporal and spatial patterns in the developing neural tube." Genes & Dev. 5: 381-388. Roelink, H., et al. (1994) "Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord." Cell 76: 761-775. Tabata, T. (1992) "The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation." Genes Dev. 6: 2835-2646. Tashiro, S. (1993) "Structure and expression of hedgehog, a Drosophila segment-polarity gene required for cell-cell communication." Gene 124: 183-189. Taylor, A.M., et al. (1993) "Contrasting distrubutions of patched and hedgehog proteins in the Drosophila embryo." Mech. Dev. 42: 89-96. Yamada, T., et al. (1991)"Control of cell pattern in the developing nervous system: polarizing activity of the floor plate and notochord." Cell 64: 635-647; and. Yamada, T., et al. (1993) "Control of cell pattern in the neural tube: motor neuron induction by diffusible factors from notochord and floor plate." Cell 73: 673-686. Riddle, R.D. (1993) "Sonic hedgehog mediates the polarizing activity of the ZPA." Cell 75: 1401-1416; and. Echelard, Y. (1993) "Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity." Cell 75: 1417-1430.