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특허 상세정보

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Process for producing small particles of biologically active molecules

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A61K-009/16   
미국특허분류(USC) 424/489; 424/499; 424/502; 424/600
출원번호 US-0006682 (1993-01-21)
발명자 / 주소
출원인 / 주소
대리인 / 주소
    Hamilton, Brook Smith & Reynolds, P.C.
인용정보 피인용 횟수 : 73  인용 특허 : 4
초록
▼

Small diameter particles of biologically active molecules are produced by atomizing solutions of the molecules through a nozzle into very cold liquified gases, which immediately freeze the atomized droplets. The resulting frozen particles having diameters of approximately 10 to 90 micrometers are lyophilized to produce porous particles, suspended in a non-solvent for the molecules, and exposed to ultrasonic energy or homogenization to produce particles having diameters of 0.1 to 10 micrometers with greater than 70 to 95% of the initial biological activit...

대표
청구항
▼

1. A process for making porous particles of biologically active molecules from particles having a diameter of approximately 10 to 90 micrometers comprising: providing a solution of biologically active molecules selected from the group consisting of carbohydrates, nucleotides, inorganic compounds, synthetic organic molecules, polypeptides, and lipids, in a solvent that can be removed by lyophilization; atomizing the solution into a liquified gas selected from the group consisting of nitrogen, argon, and oxygen in a vessel to produce frozen particles co...

이 특허에 인용된 특허 (4)

  1. Senyei Andrew E. (Chicago IL) Widder Kenneth J. (Chicago IL). Method of incorporating water-soluble heat-sensitive therapeutic agents in albumin microspheres. USP1982114357259.
  2. Fong Jones W. (Parsippany NJ). Process for preparation of microspheres and modification of release rate of core material. USP1984104479911.
  3. Knitsch Karl-Wolfgang (Starnberg DE1) Hagen Alexander (Tutzing DE1) Munz Eberhard (Polling DE1) Determann Helmut (Starnberg DE1). Production of porous tablets. USP1979014134943.
  4. Kalopissis ; Gregoire ; Jacquet ; Bernard ; Lang ; Gerard. Protecting skin and hair with cosmetic compositions containing superoxide dismutase. USP1978124129644.

이 특허를 인용한 특허 피인용횟수: 73

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