Coated chewing gum products containing antacid and method of making
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A23G-003/30
A61K-009/68
출원번호
US-0654464
(2000-09-01)
발명자
/ 주소
Zyck, Daniel J.
Greenberg, Michael J.
Barkalow, David G.
Marske, Scott W.
Schnell, Philip G.
Mazzone, Philip
출원인 / 주소
Wm. Wrigley Jr. Company
대리인 / 주소
Shurtz, Steven P.Brinks Hofer Gilson & Lione
인용정보
피인용 횟수 :
11인용 특허 :
165
초록▼
A method of making antacid coated chewing gum products comprises the steps of providing chewing gum cores; providing a coating syrup comprising a bulk sweetener and calcium carbonate having a median particle size of greater than about 3 microns and being suspended in the coating syrup; and applying
A method of making antacid coated chewing gum products comprises the steps of providing chewing gum cores; providing a coating syrup comprising a bulk sweetener and calcium carbonate having a median particle size of greater than about 3 microns and being suspended in the coating syrup; and applying the coating syrup to the cores and drying the syrup to produce a coating on the cores, the coating containing from about 25% to about 60% calcium carbonate.
대표청구항▼
A method of making antacid coated chewing gum products comprises the steps of providing chewing gum cores; providing a coating syrup comprising a bulk sweetener and calcium carbonate having a median particle size of greater than about 3 microns and being suspended in the coating syrup; and applying
A method of making antacid coated chewing gum products comprises the steps of providing chewing gum cores; providing a coating syrup comprising a bulk sweetener and calcium carbonate having a median particle size of greater than about 3 microns and being suspended in the coating syrup; and applying the coating syrup to the cores and drying the syrup to produce a coating on the cores, the coating containing from about 25% to about 60% calcium carbonate. cid-labile proton pump inhibitor with a base, and wherein the acid-labile active compound in the individual active compound units is surrounded by a mixture of at least one sterol and at least one polymer, by at least one fatty alcohol or by a mixture of at least one fatty alcohol and at least one polymer and/or at least one sterol. 5. An oral administration form as claimed in claim 4, wherein the acid-labile active compound in the individual active compound units is surrounded by a mixture of at least one sterol and at least one polymer. 6. An administration form as claimed in claim 1, wherein the acid-labile active compound is an acid-labile proton pump inhibitor, a salt of an acid-labile proton pump inhibitor with a base and a hydrate of a salt of an acid-labile proton pump inhibitor with base. 7. An administration form as claimed in claim 1, wherein the acid-labile active compound is pantoprazole, omeprazole, esomeprazole, lansoprazole or rabeprazole. 8. An administration form as claimed in claim 1, wherein the acid-labile active compound is pantoprazole sodium sesquihydrate. 9. An administration form as claimed in claim 4, wherein the sterol is cholesterol, lanosterol, ergosterol, stigmasterol, sitosterol, brassicasterol, campesterol or a mixture thereof. 10. An administration form as claimed in claim 4, wherein the polymer is polyvidone, vinylpyrrolidone/vinyl acetate copolymer, polyvinyl acetate, methylcellulose, ethylcellulose, hydroxypropylcellulose, cellulose ester or mixtures thereof. 11. An administration form as claimed in claim 4, wherein the fatty alcohol is cetyl alcohol, myristyl alcohol, stearyl alcohol or a mixture thereof. 12. A method for overcoming a need for an enteric layer in preparing a stable oral administration form for an acid-labile active compound which is a member selected from the group consisting of an acid-labile proton pump inhibitor, a salt of an acid-labile proton pump inhibitor with a base, and a hydrate of a salt of an acid-labile proton pump inhibitor with a base, which comprises surrounding a plurality of individual units of the acid-labile active compound by a) a mixture of at least one sterol and at least one polymer, b) at least one fatty alcohol, or c) a mixture of at least one fatty alcohol and at least one polymer and/or at least one sterol. 13. A process for producing an oral administration form as claimed in claim 1 which comprises surrounding the acid-labile active compound with a mixture of a suitable pharmaceutical or auxiliary and a) a mixture of at least one sterol and at least one polymer, b) at least one fatty alcohol, or c) a mixture of at least one fatty alcohol and at least one polymer and/or at least one sterol. 14. A method of orally administering an effective amount of a stable form of acid-labile active compound to a subject in need of such therapy, wherein the acid-labile active compound is in the form as claimed in claim 4. 15. An oral administration form as claimed in claim 1, wherein the salt of an acid-labile proton pump inhibitor with a base is a sodium, potassium, magnesium or calcium salt. 16. An oral administration form as claimed in claim 1, wherein the acid-labile proton pump inhibitor is a pure enantiomer of the acid-labile proton pump inhibitor. 17. An oral administration form as claimed in claim 4, which is a tablet, an effervescent tablet, powder in a sachet, a coated tablet or a capsule. 18. An oral administration form as claimed in claim 4, wherein the individual active compound units have a particle size less than 200 μm. 19. An oral administration form as claimed in claim 4, wherein the individual active compound units have a particle size less than 100 μm. 20. An oral administration form as claimed in claim 4, wherein the individual active compound units have a particle size in the range from 4 to 20 μm. 21. An oral administration form according to claim 5, wherein the amount (in % by weight) of acid-labile active compound in the ind
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