초록

A matrix is disclosed including a core showing a system of micropores and a surface in which the micropore system has openings. The characterizing feature is that the surface is coated with a polymer (I) having such a large molecular weight that it cannot penetrate into the micropores.

대표청구항 ▼

1. A multifunctional matrix comprising a core showing a micropore system and a surface in which the micropore system has openings, said surface delimiting said openings, wherein the surface is covered with a polymer (I) having a large molecular weight preventing said polymer (I) from penetrating int

1. A multifunctional matrix comprising a core showing a micropore system and a surface in which the micropore system has openings, said surface delimiting said openings, wherein the surface is covered with a polymer (I) having a large molecular weight preventing said polymer (I) from penetrating into the micropore system, said polymer (I) having different functional groups than the micropore system and wherein a material to be separated from a mixture can penetrate the micropore system while at least some of the remaining components in the mixture are excluded. 2. The matrix according to claim 1, wherein the diameter of the openings is less than 1 μm. 3. The matrix according to claim 1, wherein the micropore system represents a diffusive pore system with openings preventing convective mass transport into the system. 4. The matrix according to claim 1, wherein the surface in the micropores and polymer I are hydrophilic. 5. The matrix according to claim 1, wherein the surface in the micropores show hydroxy groups. 6. The matrix according to claim 1, wherein the polymer I has been cross-linked and/or covalently bound to the surface in which the micropore system has openings. 7. The matrix according to claim 1, wherein the core is built of a polymer (II). 8. The matrix according to claim 7, wherein the polymer II is hydrophobic and that its surfaces have been hydrophilized. 9. The matrix according to claim 1, wherein at least one of polymer I and II is a hydrophilic polymer. 10. The matrix of claim 9, wherein said hydrophilic polymer is a polyhydroxypolymer. 11. The matrix of claim 10, wherein said polyhydroxypolymer is a polysaccharide. 12. The matrix of claim 10, wherein said polyhydroxypolymer is cross-linked. 13. The matrix according to claim 1, wherein at least one of polymer I and II are selected from the group consisting of pullulane, starch, cellulose, dextran and agarose. 14. The matrix according to claim 13, wherein the micro pores are more difficult to penetrate than the surface which is coated with polymer I. 15. The matrix according to claim 1, wherein the surface, showing polymer I, and the micropore system in the core have different densities in relation to penetration ability by compounds with a certain molecular weight or shape, or a certain molecular weight and shape. 16. The matrix according to claim 15, wherein the micro pores are easier to penetrate than the surface which is coated with polymer I. 17. The matrix according to claim 1, wherein the micropores or polymer I, or the micropores and polymer I, show at least one ligand selected from the group consisting of a. ion exchanging groups, b. bioaffinity groups, c. hydrophobic groups, d. groups which can be exploited for covalent chromatography, e. chelate or chelating groups, f. groups with aromatic systems which can be exploited for so called π-π-interaction, g. hydrogen binding groups, and h. hydrophilic groups. 18. The matrix according to claim 17, wherein the substitution degree for at least one of the selected ligands in the micropores is different from the substitution degree for the same ligand in the surface layer which is built of polymer I. 19. The matrix according to claim 17, wherein the substitution degree for at least one of the selected ligands in the micropores or in polymer I is substantially 0. 20. The matrix according to claim 1, wherein said matrix is in the form of a set of particles whose particle size is in the interval 1-10,000 μm. 21. The matrix according to claim 20, wherein the particles when filled with a liquid medium, have a density which is distinct from that of the liquid medium. 22. The matrix according to claim 20, wherein said matrix is monodisperse. 23. The matrix according to claim 20, wherein the particles represent sizes or densities, or sizes and densities, within an interval.