Arrays and methods for detecting nucleic acids
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IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C12Q-001/68
C12M-001/34
C07H-021/04
C07H-021/02
출원번호
US-0768626
(2001-01-25)
발명자
/ 주소
Fodor, Stephen P. A.
Solas, Dennis W.
Dower, William J.
출원인 / 주소
Affymetrix Inc.
대리인 / 주소
Morgan, Lewis & Bockius LLP
인용정보
피인용 횟수 :
156인용 특허 :
167
초록▼
The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and
The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
대표청구항▼
The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and
The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources. gle-Chain Antigen-Binding Proteins", Science, vol. 242, pp. 423-426, Oct. 21, 1988. Carlsen et al., "Human Chorionic Gonadotropin Linear Amino Acid Sequence of the β Subunit", J. Biol. Chem., vol. 248, No. 19, pp. 6810-6827, 1973. *Edmundson et al., "A Search For Site-Filling Ligands in the Mcg Bence-Jones Dimer: Crystal Binding Studies of Fluorescent Compounds", Molecular Immunology, vol. 21, No. 7, pp. 561-576, 1984. *Farkas et al., "Fluorescence properties of bichromophoric molecules", Spectrochimica, vol. 48A, No. 1, pp. 95-99, 1992. 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Stavrianopoulos Jannis (New York NY) Rabbani Elazar (New York NY) Abrams Samuel B. (New York NY) Wetmur James G. (Scardsdale NY), Analyte detection by means of energy transfer.
Malmros Mark K. (P.O. Box 106 Washington Crossing PA 18977), Analytical device having semiconductive organic polymeric element associated with analyte-binding substance.
Dixon Arthur E. (41 Lane Crescent Kitchener ; Ontario CAX N2K 1P2) Damaskinos Savvas (Kitchener CAX) Bowron John W. (Waterloo CAX), Apparatus and method for method for spatially- and spectrally-resolved measurements.
Fodor Stephen P. A. (Palo Alto CA) Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA) Stryer Lubert (Stanford CA), Array of oligonucleotides on a solid substrate.
Palva Airi M. (Helsinki FIX) Ranki Tuula M. (Espoo FIX) Sderlund Hans E. (Espoo FIX), Arrays of alternating nucleic acid fragments for hybridization arrays.
Dattagupta Nanibhushan (West Haven CT) Rae Peter M. M. (Hamden CT) Rabin Daniel U. (Branford CT) Huguenel Edward D. (Guilford CT), Assay for nucleic acid sequences in an unpurified sample.
Andrus William A. (San Francisco CA) McCollum Christie D. (Foster City CA) Zon Gerald (San Carlos CA), Automated system for polynucleotide synthesis and purification.
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Rabbani Elazar (New York NY) Engelhardt Dean L. (New York NY), Composition and method for the detection of the presence of a polynucleotide sequence of interest.
Hubbell Earl A. (Mt. View CA) Lipshutz Robert J. (Palo Alto CA) Morris Macdonald S. (San Jose CA) Winkler James L. (Palo Alto CA), Computer-aided engineering system for design of sequence arrays and lithographic masks.
Hubbell Earl A. (Mt. View CA) Morris MacDonald S. (San Jose CA) Winkler James L. (Palo Alto CA), Computer-aided engineering system for design of sequence arrays and lithographic masks.
Omichinski James G. (Potomac MD) Fassina Giorgio (Padova MD ITX) Olson Arthur D. (Silver Spring MD) Thorgeirsson Snorri S. (Bethesda MD), Computer-assisted design of anti-peptides based on the amino acid sequence of a target peptide.
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Longiaru Mathew (West Orange NJ) Silver Sheryl B. (Fort Lee NJ) Sulzinski Michael A. (Spring Valley NY), Detection of chlamydia trachomatis by polymerase chain reaction using biotin labelled lina primers and capture probes.
Gordon Julian (Arlesheim CHX) Hawkes Richard (Allschwil IL CHX) Niday Evelyn (Arlington Heights IL) Towbin Harry (Allschwil CHX), Devices and kits for immunological analysis.
Schnur Joel M. (6009 Lincolnwood Ct. Burke VA 22015) Schoen Paul E. (5006 Taney Ave. Alexandria VA 22304) Peckerar Martin C. (12917 Buccaneer Rd. Silver Spring MD 20904) Marrian Christie R. K. (6805 , High resolution patterning on solid substrates.
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Hollis Mark A. (Concord MA) Ehrlich Daniel J. (Lexington MA) Murphy R. Allen (Boxboro MA) Kosicki Bernard B. (Acton MA) Rathman Dennis D. (Ashland MA) Chen Chang-Lee (Sudbury MA) Mathews Richard H. (, Optical and electrical methods and apparatus for molecule detection.
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Mullis Kary B. (La Jolla CA) Erlich Henry A. (Oakland CA) Gelfand David H. (Oakland CA) Horn Glenn (Emeryville CA) Saiki Randall K. (Richmond CA), Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme.
Stead Cecil V. (Manchester GB2) Lowe Christopher R. (Saffron Walden GB2), Protein adsorbent including a colored compound containing a quaternary ammonium especially amidinium or guanidimium cati.
Clark Noel A. (Boulder CO) Douglas Kenneth (Boulder CO) Rothschild Kenneth J. (Newton MA), Self-assembled nanometer lithographic masks and templates and method for parallel fabrication of nanometer scale multi-d.
Barrett Ronald W. (Sunnyvale CA) Pirrung Michael C. (Durham NC) Stryer Lubert (Stanford CA) Holmes Christopher P. (Sunnyvale CA) Sundberg Steven A. (San Francisco CA), Spatially-addressable immobilization of anti-ligands on surfaces.
Fodor Stephen P. A. (Palo Alto CA) Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA) Stryer Lubert (Stanford CA), Synthesis and screening of immobilized oligonucleotide arrays.
Kornreich Wayne D. (San Diego CA) Anderson Harry A. (San Diego CA) Porter John S. (Leucadia CA) Rivier Jean E. F. (La Jolla CA), Synthesis of N-substituted peptide amides.
Fuller William D. (San Diego CA) Cohen Michael P. (Salona Beach CA) Naider Fred R. (Staten Island NY) Goodman Murray (LaJolla CA), Urethane-protected amino acid-N-carboxyanhydrides.
Fodor Stephen P. A. (Palo Alto CA) Stryer Lubert (Stanford CA) Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA), Very large scale immobilized polymer synthesis.
Winkler James L. (Palo Alto CA) Fodor Stephen P. A. (Palo Alto CA) Buchko Christopher J. (Palo Alto CA) Ross Debra A. (Fremont CA) Aldwin Lois (San Mateo CA), Very large scale immobilized polymer synthesis using mechanically directed flow paths.
Cozzette Stephen N. (Nepean CAX) Davis Graham (Plainsboro NJ) Itak Jeanne A. (North Brunswick NJ) Lauks Imants R. (Yardley PA) Mier Randall M. (Morrisville PA) Piznik Sylvia (Jackson NJ) Smit Nicolaa, Wholly microfabricated biosensors and process for the manufacture and use thereof.
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Funahashi, Yasuhiro; Kadowaki, Tadashi; Matsui, Junji; Simon, Jason S.; Xu, Lucy, Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds.
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Kersey, Alan; Moon, John A.; Putnam, Martin A., Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same.
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Moon, John A.; Putnam, Martin A.; Kersey, Alan D.; Szczepanek, Paul, Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction.
Casbon, James; Brenner, Sydney; Osborne, Robert; Lichtenstein, Conrad; Claas, Andreas, Method for preparing a counter-tagged population of nucleic acid molecules.
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Williams, Peter; Taylor, Thomas J.; Williams, Daniel J. B.; Gould, Ian; Hayes, Mark A., Method of determining the nucleotide sequence of oligonucleotides and DNA molecules.
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Quake,Stephen; Braslavsky,Ido; Hebert,Benedict; Kartalov,Emil, Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension.
Fu, Glenn; Rudoff, Roger; Stern, David; Wu, George T.; Fodor, Stephen P. A.; Facer, Geoffrey, Methods and systems for digitally counting features on arrays.
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