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특허 상세정보

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Methods for providing differentiated stem cells

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) C12N-005/00    C07H-021/02    C07H-021/04    C07H-021/00   
미국특허분류(USC) 435/325; 536/023.1; 536/023.4; 536/024.1; 536/255
출원번호 US-0783203 (2001-02-13)
발명자 / 주소
  • Gold, Joseph D.
  • Lebkowski, Jane S.
출원인 / 주소
  • Geron Corporation
대리인 / 주소
    Schiff, J. MichaelEarp, David J.
인용정보 피인용 횟수 : 63  인용 특허 : 17
초록
▼

This invention provides a system for producing differentiated cells from a stem cell population for use wherever a relatively homogenous cell population is desirable. The cells contain an effector gene under control of a transcriptional control element (such as the TERT promoter) that causes the gene to be expressed in relatively undifferentiated cells in the population. Expression of the effector gene results in depletion of undifferentiated cells, or expression of a marker that can be used to remove them later. Suitable effector sequences encode a toxi...

대표
청구항
▼

This invention provides a system for producing differentiated cells from a stem cell population for use wherever a relatively homogenous cell population is desirable. The cells contain an effector gene under control of a transcriptional control element (such as the TERT promoter) that causes the gene to be expressed in relatively undifferentiated cells in the population. Expression of the effector gene results in depletion of undifferentiated cells, or expression of a marker that can be used to remove them later. Suitable effector sequences encode a toxi...

이 특허에 인용된 특허 (17)

  1. Taketo Makoto (Bar Harbor ME), Cellular enhancer for expressing genes in undifferentiated stem cells.
  2. Levesque Michel F. ; Neuman Toomas, Conversion of non-neuronal cells into neurons: transdifferentiation of epidermal cells.
  3. Woo Savio L. C. (Houston TX) Chen Shu-Hsia (Houston TX), Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk.
  4. Carpenter Melissa, Human CNS neural stem cells.
  5. Gearhart John D. ; Shamblott Michael Joseph, Human embryonic pluripotent germ cells.
  6. Tsukamoto Ann ; Baum Charles M. ; Aihara Yukoh,JPX ; Weissman Irving, Human hematopoietic stem cell.
  7. Anderson David J. (Altadena CA) Stemple Derek L. (Newton MA), Immoralized neural crest stem cells and methods of making.
  8. Weiss Samuel,CAX ; Reynolds Brent,CAX ; Hammang Joseph P. ; Baetge E. Edward, In vitro growth and proliferation of multipotent neural stem cells and their progeny.
  9. Bruder Scott P. ; Caplan Arnold I. ; Haynesworth Stephen E., Lineage-directed induction of human mesenchymal stem cell differentiation.
  10. Gage Fred H. ; Ray Jasodhara, Method for production of neuroblasts.
  11. Gage Fred H. (La Jolla CA) Rosenberg Michael B. (San Diego CA) Friedmann Theodore (La Jolla CA), Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system.
  12. Gay David A. (San Diego CA), Method of isolating a lineage specific stem cell in vitro.
  13. Orgill Dennis P. ; Butler Charles E. ; Barlow Mark ; Ritterbush Scott ; Yannas Ioannis V. ; Compton Carolyn C., Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft.
  14. Shay Jerry (Dallas TX) West Michael David (Belmont CA) Wright Woodring E. (Arlington TX), Methods for cancer diagnosis and prognosis.
  15. Thomson James A., Primate embryonic stem cells.
  16. Wheeler Matthew B., Transgenic swine compositions and methods.
  17. Wheeler Matthew B. (Tolono IL), Transgenic swine compositions and methods.

이 특허를 인용한 특허 (63)

  1. Fraser, John K.; Hedrick, Marc H., Adipose-derived regenerative cells for treating liver injury.
  2. Fraser, John K.; Hedrick, Marc H., Autologous adipose tissue implant with concentrated stem cells.
  3. Hedrick, Marc H.; Fraser, John K.; Schulzki, Michael J.; Byrnes, Bobby; Carlson, Grace; Schreiber, Ronda Elizabeth; Wulur, Isabella, Automated methods for isolating and using clinically safe adipose derived regenerative cells.
  4. Hyde, Roderick A.; Kindsvogel, Wayne R.; McKnight, Gary L., Compositions and methods including cytotoxic B lymphocyte cell line expressing exogenous membrane immunoglobulin different from secreted immunoglobulin.
  5. Hyde, Roderick A.; Kindsvogel, Wayne R., Compositions and methods including recombinant B lymphocyte cell line including an exogenously incorporated nucleic acid expressing an exogenous membrane immunoglobulin reactive to a first antigen and including an endogenous gene expressing an endogenous secreted immunoglobulin reactive to a second antigen.
  6. Hyde, Roderick A.; Kindsvogel, Wayne R., Compositions and methods including recombinant B lymphocyte cell line including an exogenously incorporated nucleic acid expressing an exogenous membrane immunoglobulin reactive to a first antigen and including an endogenous gene expressing an endogenous secreted immunoglobulin reactive to a second antigen.
  7. Hyde, Roderick A.; Kindsvogel, Wayne R., Compositions and methods including recombinant B lymphocyte cell line including an exogenously incorporated nucleic acid expressing an exogenous membrane immunoglobulin reactive to a first antigen and including an endogenous gene expressing an endogenous secreted immunoglobulin reactive to a second antigen.
  8. Hyde, Roderick A.; Kindsvogel, Wayne R., Compositions and methods including recombinant B lymphocyte cell line including an exogenously incorporated nucleic acid expressing an exogenous membrane immunoglobulin reactive to a first antigen and including an endogenous gene expressing an endogenous secreted immunoglobulin reactive to a second antigen.
  9. Hyde, Roderick A.; Kindsvogel, Wayne R., Compositions and methods including recombinant B lymphocyte cell line including at least one endogenous gene expressing at least one endogenous membrane immunoglobulin reactive to a first antigen and including at least one exogenously incorporated nucleic acid expressing at least one exogenous secreted immunoglobulin reactive to a second antigen.
  10. Hyde, Roderick A.; Kindsvogel, Wayne R., Compositions and methods including recombinant B lymphocyte cell line including at least one endogenous gene expressing at least one endogenous membrane immunoglobulin reactive to a first antigen and including at least one exogenously incorporated nucleic acid expressing at least one exogenous secreted immunoglobulin reactive to a second antigen.
  11. Hyde, Roderick A.; Kindsvogel, Wayne R., Compositions and methods including recombinant B lymphocyte cell line including at least one endogenous gene expressing at least one endogenous membrane immunoglobulin reactive to a first antigen and including at least one exogenously incorporated nucleic acid expressing at least one exogenous secreted immunoglobulin reactive to a second antigen.
  12. Amit, Michal; Itskovitz-Eldor, Joseph, Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state.
  13. Mandalam, Ramkumar; Xu, Chunhui; Gold, Joseph D.; Carpenter, Melissa K., Human embryonic stem cells genetically modified to contain a nucleic acid and cultured with fibroblast growth factor.
  14. Gold, Joseph D.; Lebkowski, Jane S., In vitro differentiated cell and human embryonic stem cell population.
  15. Offen, Daniel; Bahat-Stromza, Merav; Melamed, Eldad, Isolated cells and populations comprising same for the treatment of CNS diseases.
  16. Offen, Daniel; Bahat-Stromza, Merav; Melamed, Eldad, Isolated cells and populations comprising same for the treatment of CNS diseases.
  17. Gold, Joseph D; Lebkowski, Jane S, Isolated in vitro cell population comprising primate pluripotent stem cells containing a nucleic acid construct and differentiated progeny of the pluripotent stem cells.
  18. Amit, Michal; Itskovitz-Eldor, Joseph, Media for culturing stem cells.
  19. Amit, Michal; Itskovitz-Eldor, Joseph, Medium comprising transforming growth factor beta 1 and basic fibroblast growth factor.
  20. Amit, Michal; Itskovitz-Eldor, Joseph, Medium comprising transforming growth factor beta 1 and basic fibroblast growth factor.
  21. Amit, Michal; Itskovitz-Eldor, Joseph, Medium comprising transforming growth factor β1 and basic fibroblast growth factor.
  22. Kadouri, Avinoam; Bar-Ilan, Avihay; Melamed, Eldad; Offen, Daniel; Sadan, Ofer; Bahat-Stromza, Merav, Mesenchymal stem cells for the treatment of CNS diseases.
  23. Kadouri, Avinoam; Bar-Ilan, Avihay; Melamed, Eldad; Offen, Daniel; Sadan, Ofer; Bahat-Stromza, Merav, Mesenchymal stem cells for the treatment of CNS diseases.
  24. Kadouri, Avinoam; Bar-Ilan, Avihay; Melamed, Eldad; Offen, Daniel; Sadan, Ofer; Bahat-Stromza, Merav, Mesenchymal stem cells for the treatment of CNS diseases.
  25. Kadouri, Avinoam; Bar-Ilan, Avihay; Melamed, Eldad; Offen, Daniel; Sadan, Ofer; Bahat-Stromza, Merav, Mesenchymal stem cells for the treatment of CNS diseases.
  26. Hedrick, Marc H.; Fraser, John K.; Riley, Susan Lynn; Tai, Joseph W., Method for processing and using adipose-derived stem cells.
  27. Chesnut, Jonathan D.; Carrino, John; Leong, Louis; Madden, Knut; Gleeson, Martin; Fan, James; Brasch, Michael; Cheo, David; Hartley, James L.; Byrd, Devon R.; Temple, Gray F., Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites.
  28. Chesnut, Jonathan; Carrino, John; Leong, Louis; Madden, Knut; Gleeson, Martin; Fan, James; Brasch, Michael; Cheo, David; Hartley, James; Byrd, Devon; Temple, Gary, Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites.
  29. Chesnut, Jonathan; Carrino, John; Leong, Louis; Madden, Knut; Gleeson, Martin; Fan, James; Brasch, Michael; Cheo, David; Hartley, James; Byrd, Devon; Temple, Gary, Methods and compositions for synthesis of nucleic acid molecules using multiplerecognition sites.
  30. Amit, Michal; Itskovitz-Eldor, Joseph, Methods of expanding embryonic stem cells in a suspension culture.
  31. Amit, Michal; Itskovitz-Eldor, Joseph, Methods of expanding embryonic stem cells in a suspension culture.
  32. Fraser, John K.; Hedrick, Marc H., Methods of making enhanced, autologous fat grafts.
  33. Hedrick, Marc H.; Fraser, John K.; Riley, Susan Lynn; Schreiber, Ronda Elizabeth, Methods of using adipose derived regenerative cells to promote restoration of intevertebral disc.
  34. Fraser, John K.; Hedrick, Marc H.; Daniels, Eric, Methods of using adipose derived stem cells to promote wound healing.
  35. Fraser, John K.; Hedrick, Marc H.; Daniels, Eric, Methods of using adipose derived stem cells to treat acute tubular necrosis.
  36. Hedrick, Marc H.; Fraser, John K., Methods of using adipose tissue-derived cells in augmenting autologous fat transfer.
  37. Hedrick, Marc H.; Fraser, John K., Methods of using adipose tissue-derived cells in augmenting autologous fat transfer.
  38. Hedrick, Marc H.; Fraser, John K., Methods of using adipose tissue-derived cells in augmenting autologous fat transfer.
  39. Fraser, John K.; Hedrick, Marc H.; Zhu, Min; Strem, Brian M.; Daniels, Eric; Wulur, Isabella, Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions.
  40. Alfonso, Zeni; Fraser, John K., Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease.
  41. Alfonso, Zeni; Fraser, John K., Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease.
  42. Fraser, John K.; Hedrick, Marc H.; Daniels, Eric, Methods of using adipose-derived regenerative cells in the treatment of peripheral vascular disease and related disorders.
  43. Hedrick, Marc H.; Fraser, John K.; Riley, Susan L.; Schreiber, Ronda E., Methods of using regenerative cells in the treatment of cartilage defects.
  44. Fraser, John K.; Hedrick, Marc H.; Daniels, Eric, Methods of using regenerative cells in the treatment of erectile dysfunction.
  45. Hedrick, Marc H.; Fraser, John K.; Riley, Susan Lynn; Schreiber, Ronda Elizabeth, Methods of using regenerative cells in the treatment of musculoskeletal disorders.
  46. Fraser, John K.; Hedrick, Marc H.; Strem, Brian M., Methods of using regenerative cells in the treatment of stroke and related diseases and disorders.
  47. Fraser, John K.; Hedrick, Marc H.; Daniels, Eric, Methods of using regenerative cells to promote epithelialization or neodermis formation.
  48. Fraser, John K.; Hedrick, Marc H.; Daniels, Eric, Methods of using regenerative cells to promote wound healing.
  49. Fraser, John K.; Hedrick, Marc H.; Daniels, Eric, Methods of using regenerative cells to treat a burn.
  50. Fraser, John K.; Hedrick, Marc H.; Daniels, Eric, Methods of using regenerative cells to treat an ischemic wound.
  51. Hariri, Robert J.; Stirling, David I.; Moutouh-De Parseval, Laure A.; Chan, Kyle W. H., Modulation of stem and progenitor cell differentiation, assays, and uses thereof.
  52. Hariri,Robert J.; Stirling,David I.; Moutouh De Parseval,Laure A.; Chan,Kyle W. H., Modulation of stem and progenitor cell differentiation, assays, and uses thereof.
  53. Stice, Steve; Shin, Soojung; Dhara, Sujoy, Neuronal progenitors from feeder-free human embryonic stem cell culture.
  54. Stice, Steve; Shin, Soojung; Dhara, Sujoy, Neuronal progenitors from feeder-free human embryonic stem cell culture.
  55. Lu, Baisong; Zhao, Qingguo; Yoo, James; Atala, Anthony, Non-viral episomal suicide construct.
  56. Chesnut, Jon; Leong, Louis, Nucleic acid molecules containing recombination sites and methods of using the same.
  57. Chesnut, Jonathan; Leong, Louis, Nucleic acid molecules containing recombination sites and methods of using the same.
  58. Mandalam, Ramkumar; Xu, Chunhui; Gold, Joseph D.; Carpenter, Melissa K., Primate pluripotent stem cell expansion without feeder cells and in the presence of FGF and matrigel or Engelbreth-Holm-Swarm tumor cell preparation.
  59. Mandalam, Ramkumar; Xu, Chunhui; Gold, Joseph D.; Carpenter, Melissa K., Screening methods for human embryonic stem cells.
  60. Mandalam, Ramkumar; Li, Yan; Nadeau-Demers, Isabelle, Suspension culture of human embryonic stem cells.
  61. Hedrick, Marc H.; Fraser, John K.; Schulzki, Michael J.; Byrnes, Bobby; Carlson, Grace; Schreiber, Ronda Elizabeth; Wulur, Isabella, Systems and methods for isolating and using clinically safe adipose derived regenerative cells.
  62. Hedrick, Marc H.; Fraser, John K.; Schulzki, Michael J.; Byrnes, Bobby; Carlson, Grace; Shanahan, Robert K., Systems and methods for separating and concentrating adipose derived stem cells from tissue.
  63. Peterson, Alvin; Fornace, Lucas, Systems, methods and compositions for optimizing tissue and cell enriched grafts.

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