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A process for preparing a chewing gum tablet includes cooling a chewing gum composition to a temperature at which the gum composition is brittle, and grinding the cooled, brittle gum composition to form a chewing gum powder. The gum composition can be cooled by mixing it with a coolant, such as soli

A process for preparing a chewing gum tablet includes cooling a chewing gum composition to a temperature at which the gum composition is brittle, and grinding the cooled, brittle gum composition to form a chewing gum powder. The gum composition can be cooled by mixing it with a coolant, such as solid carbon dioxide, prior to grinding. The chewing gum powder is mixed with an active composition comprising a nutritional supplement, such as one or more vitamins, minerals, or herbs, to form a nutritional supplement-containing powder. The mixture of gum powder and the nutritional supplement, along with other optional additives, is then granulated to form nutritional supplement-containing granules. These granules are then compressed to form chewing gum tablets.

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A process for preparing a chewing gum tablet includes cooling a chewing gum composition to a temperature at which the gum composition is brittle, and grinding the cooled, brittle gum composition to form a chewing gum powder. The gum composition can be cooled by mixing it with a coolant, such as soli

A process for preparing a chewing gum tablet includes cooling a chewing gum composition to a temperature at which the gum composition is brittle, and grinding the cooled, brittle gum composition to form a chewing gum powder. The gum composition can be cooled by mixing it with a coolant, such as solid carbon dioxide, prior to grinding. The chewing gum powder is mixed with an active composition comprising a nutritional supplement, such as one or more vitamins, minerals, or herbs, to form a nutritional supplement-containing powder. The mixture of gum powder and the nutritional supplement, along with other optional additives, is then granulated to form nutritional supplement-containing granules. These granules are then compressed to form chewing gum tablets. ors," Powder Technology, pp. 302-313 (1984). G.K. Budrik et al., "Ejector Feeders for Pneumatic Transport Systems," Chemical and Petroleum Engineering, vol. 14, Nos. 9-10, Sep.-Oct. 1978. P.R. Byron et al., "Drug Delivery via the Respiratory Tract," J. of Aerosol Medicine, vol. 7, No. 1 (1994), pp. 49-75. Y. W. Chien et al., "Intranasal Drug Delivery for Systemic Medications," CRC Critical Reviews in Therapeutic Drug Carries Systems, vol. 4, Issue 2 (1987), pp. 67-92. P. Colthorpe et al., "The Pharmacokinetics of Pulmonary-Delivered Insulin: A Comparison of Intratracheal and Aerosol Administration to the Rabbit," Pharmaceutical Research, vol. 9, No. 6, 1992, pp. 764-768. Guus S.M.J.E. Duchateau et al., "Bile Salts and Intranasal Drug Absorption," Int'l. J. of Pharmaceuticals, vol. 31, (1986), pp. 193-199. R.B. Elliott et al., "Parenteral Absorption of Insulin from the Lung in Diabetic Children," Aust. Paediatr. J. (1987) vol. 23, 293-297. L.S. Fox et al., "Performance of a Venturi Eductor as a Feeder in a Pneumatic Conveying System," Powder and Bulk Engineering, Mar. 1988, pp. 33-36. T. Friedmann., "Progress Toward Human Gene Therapy," Science, vol. 244, Jun. 16, 1989, pp. 1275-1281. M. Gansslen, "Uber Inhalation von Insulin," Klin. Wochenschr., 1925, vol. 4, No. 71, (without translation). J.F. Habener et al., "Parathyroid Hormone: Secretion and Metabolism In Vivo," Proc. Nat. Acad. Sci. USA, vol. 68, No. 12, pp. 2986-2991, Dec. 1971. R.H. Hastings, "Clearance of Different-Sized Proteins from the Alveolar Space in Humans and Rabbits," The American Physiological Society, 1992, pp. 1310-1316. R.D. Hesch et al., "Pulsatile Secretion of Parathyroid Hormone and its Action on a Type I and Type II PTH Receptor: A Hypothesis for Understanding Osteoporosis," Calcified Tissue International, (1988), vol. 42, pp. 341-344. B.L. Laube et al., "Preliminary Study of the Efficacy of Insulin Aerosol Delivered by Oral Inhalation in Diabetic Patients," JAMA, vol. 269, No. 16, Apr. 28, 1993, pp. 2106-2109. S.W. Lee et al., "Development of an Aerosol Dosage Form Containing Insulin," Reprinted from J. of Pharmaceutical Sciences, vol. 65, No. 4, 1976, pp. 567-572. F. Liu et al., "Pulmonary Delivery of Free and Liposomal Insulin," Pharmaceutical Research, vol. 10, No. 2, 1993, pp. 228-232. M. Nagano et al., "New Method of Insulin Therapy: Transpulmonary Absorption of Insulin," Jikeikai Med. J., vol. 32, No. 3, (1985), pp. 503-506. T. Nagai et al., "Powder Dosage Form of Insulin for Nasal Administration," J. of Controlled Release, vol. 1, (1984), pp. 15-22. R.M. Neer et al., "The Use of Parathyroid Hormone Plus 1,25-Dihydroxyvitamin D to Increase Trabecular Bone in Osteoporotic Men and Postmenopausal Women," Osteoporosis, (1987), pp. 829-835. M.M. Nieminen et al., "Aerosol Deposition in Automatic Dosimeter Neubulization," European J. Resp. Dis., vol. 71, (1987), pp. 145-152. J.S. Patton et al., "Pulmonary Delivery of Peptides ad Proteins for Systemic Action," Advanced Drug Delivery Reviews, (1992) vol. 8, pp. 179-196. M.J. Pikal, "Polymorphism in Pharmaceutical Solids," AAPS, Annual Meeting and Exposition, Nov. 15-19, 1992. A.N. Pittman et al., "Pneumatic Conveying of Bulk Solids Using a Vacuum Aerated Feed Nozzel," Solids Handling Converence, (1986), Paper C4, pp. C-41 to C-51. A.R.G. Rao, "Aerosol Insulin Inhalation Enquiry," Indian J. Physiol. Pharmacol., vol. 3, (1959), pp. 161-167. M.A. Rosenfeld et al., "Adenovirus-Mediated Transfer of a Recombinant α1-Antitrypsin Gene to the Lung Epithelium in Vivo," Science, vol. 252, Apr. 19, 1991, pp. 431-434. L. Ryden et al., "Effect of Polymers and Microspheres on the Nasal Absorption of Insulin in Rats," Int'l. of Pharmaceuticals, vol. 83, (1992), pp. 1-10. F.M. Sakr, "A New Approach for Insulin Delivery via the Pulmonary Route: Design and Pharmacokinetics in Non-Diabetic Rabbits," Int'l. J. of Pharmaceuticals, vol. 86, (1992), pp. 1-7. K.J. Schluter et al., Abstract Reproductio