초록 ▼

Delivery of rapamycin locally, particularly from intravascular stent, directly from micropores in the stent body or mixed or bound to a polymer coating applied on stent, to inhibit neointimal tissue proliferation and thereby prevent restenosis. This invention also facilitates the performance of the

Delivery of rapamycin locally, particularly from intravascular stent, directly from micropores in the stent body or mixed or bound to a polymer coating applied on stent, to inhibit neointimal tissue proliferation and thereby prevent restenosis. This invention also facilitates the performance of the stent in inhibiting restenosis.

대표청구항 ▼

Delivery of rapamycin locally, particularly from intravascular stent, directly from micropores in the stent body or mixed or bound to a polymer coating applied on stent, to inhibit neointimal tissue proliferation and thereby prevent restenosis. This invention also facilitates the performance of the

Delivery of rapamycin locally, particularly from intravascular stent, directly from micropores in the stent body or mixed or bound to a polymer coating applied on stent, to inhibit neointimal tissue proliferation and thereby prevent restenosis. This invention also facilitates the performance of the stent in inhibiting restenosis. relative to said first member by rotation of said shaft member. 7. The apparatus of claim 1 wherein said first member has first and second sections connected by a bridge portion, said opening being disposed in said bridge portion. 8. An apparatus for attaching a cranial flap to a skull during surgery, the cranial flap and the skull being spaced apart by a kerf defined by a first kerf edge on the cranial flap and an oppositely disposed second kerf edge on the skull, said apparatus comprising: at least one attachment device comprising relatively movable first and second members, said first and second members being movable relative to each other along an axis; said first member having a wedge shape defined by said first and second surfaces extending at diverging angles relative to said axis, said first and second surfaces for engaging the first and second kerf edges, respectively, said first member further including an opening extending along said axis; said second member having a wedge shape defined by said third and fourth surfaces extending at diverging angles relative to said axis, said third and fourth surfaces for engaging the first and second kerf edges, respectively; and a shaft member connecting said first and second members, said shaft member being attached to said second member and extending through said opening in said first member; said at least one attachment device being positionable in the kerf and movable from a first condition in which said first surface on said first member and said third surface on said second member are not engaged with the first kerf edge and the second surface on said first member and said fourth surface on said second member are not engaged with the second kerf edge to a second condition in which said at least one attachment device is wedged in the kerf by circumferential pressure and frictional engagement between said first and third surfaces and the first kerf edge and by circumferential pressure and frictional engagement between said second and fourth surfaces and the second kerf edge to thereby attach the cranial flap to the skull and prevent the cranial flap from moving relative to the skull, said at least one attachment device in said second condition being disposed entirely within the kerf; said at least one attachment device being movable from said first condition to said second condition by axial movement of at least one said first and second members toward the other of said first and second members. 9. An apparatus for attaching a cranial flap to a skull during surgery, the cranial flap and the skull being spaced apart by a kerf defined by a first kerf edge on the cranial flap and an oppositely disposed second kerf edge on the skull, said apparatus comprising: at least one attachment device comprising relatively movable first and second members, said first and second members being movable relative to each other along an axis; said first member having oppositely disposed first and second surfaces for engaging the first and second kerf edges, respectively, said first member further including an opening extending along said axis; said second member having oppositely disposed third and fourth surfaces for engaging the first and second kerf edges, respectively; and a shaft member connecting said first and second members, said shaft member being attached to said second member and extending through said opening in said first member; said at least one attachment device being positionable in the kerf and movable from a first condition in which said first surface on said first member and said third surface on said second member are not engaged with the first kerf edge and the second surface on said first member and said fourth surface on said second member are not engaged with the second kerf edge to a second condition in which said at least one attachment device is wedged in the kerf by circumferential pressure and frictional engagement between said first and third surfac