초록 ▼

Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel po

Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel polypeptide chains and host cells transfected with these vectors; (4) methods of producing these polypeptide chains using recombinant DNA technology; (5) antibodies specific for these novel polypeptide chains; (6) osteogenic devices comprising these recombinantly produced proteins in association with an appropriate carrier matrix; and (7) methods of using the osteogenic devices to mimic the natural course of endochondral bone formation in mammals.

대표청구항 ▼

Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel po

Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel polypeptide chains and host cells transfected with these vectors; (4) methods of producing these polypeptide chains using recombinant DNA technology; (5) antibodies specific for these novel polypeptide chains; (6) osteogenic devices comprising these recombinantly produced proteins in association with an appropriate carrier matrix; and (7) methods of using the osteogenic devices to mimic the natural course of endochondral bone formation in mammals. ed Apr. 1995. Myers, M.G. and Harvey, R.G., "Triazine-Resistant Common Lambsquarters Control in Field Corn", Weed Technology 7, (1993) pp. 884-889. Moshier, L.J., "Response of Honeyvine Milkweed to Herbicide Applications", Weed Science (1980) 28(6), 722-724. Roundup Ultra herbicide booklet -21137T1-2/53. 1996. Roundup Ultra herbicide booklet -21137U2-2/53. 1996. Roundup Ultra herbicide booklet -21001S1-28/53. 1994. Material Safety Data Sheet filed with the United States Occupational Safety and Health Administration for Dual Herbicide. 1998. Material Safety Data Sheet filed with the United States Occupational Safety and Health Administration for Solicam DF Herbicide. 1999. "The Pesticide Manual, 10thEdition" (1994). Entries 369, 476, 593, 569, 202,605, 232,332, 582, 36, 148, 22, 664, 627, 577. Moser, H., Rihs, G., Sauter, H.P., and Bohner, B., "Atropisomerism, Chiral Centre and Activity of Metolachlor" Pesticide Chemistry: human welfare and the environment, vol. 1. Synthesis and structure-activity relationships (1983) pp. 315-320. Australian Weed Control Handbook, Tenth Edition, Inkata Press, Melbourne, 1995, pp. 380-396, 138-142, 127-133, 180-181, 217-230, 233-234 and 397-398. "Herbicide Handbook", Weed Science Society of America, Seventh Edition, 1994, pp. 149-152. Herbicides. Chemistry, Degradation, and Mode of Action, vol. 3 (1988), edited by P.C.Kearney and D.D.Kaufman, published by Marcel Dekker, Inc., New York, pp. 338-345 and 374-377. Harr, J., Seckinger, K., Ummel, E. and Hargett L.T. "SAN 582 H -A new herbicide for weed control in corn and soybeans", Proceedings of the Brighton Crop Protection Conference -Weeds -1991, pp. 87-92. Charles, G.W., Constable, G.A. and Kennedy, I.R. "Current and future weed control practices in cotton: the potential use of transgenic herbicide resistance" pp. 89-100 in G.D.McLean and G.Evans, (eds) 1995, Herbicide-resistant Crops and Pastures in Australian Farming Systems. Rasche, E. "Development of glufosinate ammonium tolerant crops and the selective use of the herbicide glufosinate ammonium", pp. 25-33 in G.D.McLean and G.Evans, (eds) 1995, Herbicide-resistant Crops and Pastures in Australian Farming Systems.