Multiple microchannels chip for biomolecule imaging, and method of use thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-021/64
G01N-021/01
출원번호
US-0634709
(2000-08-07)
발명자
/ 주소
Rahbar-Dehghan, Fariborz
출원인 / 주소
Royce Technologies LLC
대리인 / 주소
Hogan & Hartson, LLP
인용정보
피인용 횟수 :
9인용 특허 :
31
초록▼
A panel chip for supporting biological samples for observation with a microscope. The glass panel defines a top flat surface, a bottom bearing surface, and at least a few channels extending generally parallel to each other from top to bottom surfaces. Each of the channels defines a top access mouth
A panel chip for supporting biological samples for observation with a microscope. The glass panel defines a top flat surface, a bottom bearing surface, and at least a few channels extending generally parallel to each other from top to bottom surfaces. Each of the channels defines a top access mouth for ingress of biological samples, wherein each channel is obliquely inclined so as to make a significant acute angle relative to an axis perpendicular to said top flat surface, in order to facilitate the guidance of maximum light into the channel due to zero loss of reflection and to produce the maximum number of total internal reflection and to guide the maximum light out of the microchannel in such a manner that produces no artifact halo for maximum detection and sensitivity. Each channel has such an inner diameter as to accommodate flow through viscosity of a biological sample containing fluid.
대표청구항▼
A panel chip for supporting biological samples for observation with a microscope. The glass panel defines a top flat surface, a bottom bearing surface, and at least a few channels extending generally parallel to each other from top to bottom surfaces. Each of the channels defines a top access mouth
A panel chip for supporting biological samples for observation with a microscope. The glass panel defines a top flat surface, a bottom bearing surface, and at least a few channels extending generally parallel to each other from top to bottom surfaces. Each of the channels defines a top access mouth for ingress of biological samples, wherein each channel is obliquely inclined so as to make a significant acute angle relative to an axis perpendicular to said top flat surface, in order to facilitate the guidance of maximum light into the channel due to zero loss of reflection and to produce the maximum number of total internal reflection and to guide the maximum light out of the microchannel in such a manner that produces no artifact halo for maximum detection and sensitivity. Each channel has such an inner diameter as to accommodate flow through viscosity of a biological sample containing fluid. im 13, wherein said output velocity profile is a constant velocity profile of said spectral element throughout an oscillation angle. 15. The apparatus of claim 1, further comprising: an optical encoder for defining the postion of said spectral element. 16. The apparatus of claim 1, wherein the position of said spectral element is analytically determined by the geometry of said spatial mechanism and a known angular position of said motive source. 17. The apparatus of claim 16, wherein said analytical determination is made by any of counting steps, coupling an encoder to said motive source, and directly coupling to said second coupler to measure the angular position of said spectral element. 18. The appartus of claim 1, wherein said first coupler defines a slot along which a bushing may be positioned to increase or decrease, as desired, the extent to which said first coupler pulls said link from side to side during each rotation of said rotational input. 19. The apparatus of claim 1, wherein said spatial linkage mechanism is adapted to produce multiple oscillations during each rotation of said rotational input. 20. The apparatus of claim 1, wherein said spatial linkage mechanism is adapted to produce a fractional oscillation during each rotation of said rotational input. 21. The apparatus of claim 1, wherein said spectral element comprises any of a ruled spectral grating, a holographic grating, multiple gratings in which a plurality of gratings are coupled to a same output of said spatial linkage mechanism to allow said grating to be rotated with a same (or offset) angular position, and a prism. 22. The apparatus of claim 1, wherein said spatial linkage mechanism is used in a monochromator having a fixed spectral element and an oscillating mirror, wherein the mirror is coupled to said spatial linkage mechanism. 23. The apparatus of claim 1, wherein said first coupler further comprises a harmonic balancer. 24. An apparatus for oscillating a spectral element of a monochromator, comprising: a spatial linkage mechanism for accepting a rotational input from a motive source and converting said rotational input into an oscillatory motion, said spatial linkage mechanism comprising: a first coupler for receiving said rotational input, said first coupler rotating in accordance therewith, wherein said first coupler defines an aperture that is rotated off axis from a rotational axis of said motive source, wherein said first coupler is affixed to, or formed integrally with, a spectral element drive shaft; a link coupled to said first coupler, said link further comprising a projection that is formed on said link and that is adapted for engagement with the aperture of said first coupler, wherein said projection and said aperture are arranged to move freely, one relative to the other, wherein said link comprises a U-shaped member, wherein said link defines an aperture in each of two projecting segments, and wherein said link is configured to receive opposing, cylindircal projections that are formed on said second coupler; and a second coupler coupled to said link; wherein said link translates said rotational input of said motive source, as supplied thereto by said first coupler, to said oscillatory motion; said link imparts said oscillatory motion to said second coupler, and said second coupler oscillates said spectral element. 25. The apparatus of claim 24, wherein said spatial linkage mechanism oscillates said spectral element through one complete forward and reverse cycle for every one revolution of a shaft of said motive element. 26. The apparatus of claim 24, wherein said spatial linkage mechanism is adapted to produce multiple oscillations during each rotation of said rotational input. 27. The apparatus of claim 24, wherein said spatial linkage mechanism is adapted to produce a fractional oscillation during each rotation of said rotational input. 28. The apparatus of claim 24, wherein said spectral element comprises any of
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이 특허에 인용된 특허 (31)
Clark Carl R. (Rockford IL), Apparatus for rapid immunoassays.
Croteau Andrew J. (Old Orchard Beach ME) Pierson Mark W. (Saco ME) Townsend David E. (Scarborough ME) Naqui Ali (Falmouth ME), Method for quantification of biological material in a sample.
Suovaniemi Osmo A. (Helsinki FIX) Ekholm Pertti (Helsinki FIX) Partanen Paul (Helsinki FIX), Micro-cuvette unit for facilitating the identification of samples.
Manns Roy L. (Marshfield Hills MA) Kolb Alfred J. (Madison CT) Effertz Bernard S. (Meriden CT), Microplate forming wells with transparent bottom walls for assays using light measurements.
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