초록 ▼

A blister pack which confines the movement a dosage form in order to resist damage thereto during handling and transportation while permitting removal of the intact dosage form, and apparatus and methods for the same. In particular, the invention provides a blister pack wherein the blister includes

A blister pack which confines the movement a dosage form in order to resist damage thereto during handling and transportation while permitting removal of the intact dosage form, and apparatus and methods for the same. In particular, the invention provides a blister pack wherein the blister includes a protruding region between the opening and the base, thereby producing a constricted area or "neck" in the blister. In a preferred embodiment, the protruding region comprises an inwardly directed annulus formed in the blister wall. Accordingly, vertical movement of the dosage form is confined as a result of the protruding region, thereby reducing the likelihood of damage to the dosage form caused by agitation of the blister pack. The invention is particularly useful in packaging frangible pharmaceutical dosage forms formed in situ within the blister, such as freeze dried dosage forms and rapidly dissolving oral dosage forms.

대표청구항 ▼

A blister pack which confines the movement a dosage form in order to resist damage thereto during handling and transportation while permitting removal of the intact dosage form, and apparatus and methods for the same. In particular, the invention provides a blister pack wherein the blister includes

A blister pack which confines the movement a dosage form in order to resist damage thereto during handling and transportation while permitting removal of the intact dosage form, and apparatus and methods for the same. In particular, the invention provides a blister pack wherein the blister includes a protruding region between the opening and the base, thereby producing a constricted area or "neck" in the blister. In a preferred embodiment, the protruding region comprises an inwardly directed annulus formed in the blister wall. Accordingly, vertical movement of the dosage form is confined as a result of the protruding region, thereby reducing the likelihood of damage to the dosage form caused by agitation of the blister pack. The invention is particularly useful in packaging frangible pharmaceutical dosage forms formed in situ within the blister, such as freeze dried dosage forms and rapidly dissolving oral dosage forms. itical time selected from the group consisting of a start time for the at least one trip, an arrival time for the at least one trip, a desired start time for the at least one trip, and a day of the week when the at least one trip is to be undertaken, and at least one communication specification selected by that user, at least one processor adapted to perform the following operations processing the trip data, at a predetermined time relative to the critical time and responsive to the conditions of travel, to identify at least one situation relating to the trip data; and causing at least one user to be contacted at a second time relative to the critical time, responsive to the situation and in accordance with the communication specification; at least one communications portal for effecting contact with users and receiving the information regarding the conditions of travel. 11. The device of claim 10, wherein contact with the user further comprises communicating at least one user-specified advisory type via at least one user-specified avenue of communication. 12. The device of claim 10, wherein communication of the situation includes specifying an alternate or preferred route. 13. The device of claim 10, wherein communication of the situation includes specifying information about a delay. 14. The device of claim 10, wherein the trip data further comprises identification of appropriate ones of the trip description structures; and processing the trip data comprises checking the appropriate ones of the trip description structures against the conditions of travel. 15. The device of claim 10, wherein the processing includes comparing current speed with nominal speed, for appropriate ones of the trip description structures. 16. The device of claim 10, wherein the critical time is stored as a range of times. 17. The device of claim 10, wherein the trip data includes more than one critical time and a respective communication specification for each critical time. 18. A medium, readable by a data processing device and embodying code for carrying out operations, the operations comprising: maintaining at least one database comprising; a plurality of trip description structures; information regarding conditions of travel associated with at least one of the trip description structures in view of current information; respective trip data corresponding to at least one trip for each of a plurality of users, the trip data being communicated by the plurality of users and including, for each user: at least one geographic identification, at least one critical time selected from the group consisting of a start time for the at least one trip, an arrival time for the at least one trip, a desired start time for the at least one trip, and a day of the week when the at least one trip is to be undertaken, and at least one communication specification selected by that user, processing the trip data, at a predetermined time relative to the critical time and responsive to the conditions of travel, to identify at least one situation relating to the trip data; and contacting at least one user at a second time relative to the critical time, responsive to the situation and in accordance with the communication specification. 19. The medium of claim 18, wherein contacting a user further comprises communicating at least one user-specified advisory type via at least one user-specified avenue of communication. 20. The medium of claim 18, wherein communication of the situation includes specifying an alternate or preferred route. 21. The medium of claim 18, wherein communication of the situation includes specifying information about a delay. 22. The medium of claim 18, wherein the trip data further comprises identification of appropriate ones of the trip description structures; and processing the trip data comprises checking the appropriate ones of the trip description structures against the conditions of travel. 23. The medium of c laim 18, wherein the information relating to conditions of travel is derived from comparing current speed with nominal speed, for appropriate ones of the trip description structures. 24. The medium of claim 18, wherein the critical time is stored as a range of times. 25. The medium of claim 18, wherein the trip data includes more than one critical time and a respective communication specification for each critical time.