초록 ▼

Laser machining is often carried out using special machines or apparatus, with the workpieces having to be finished afterwards using appropriately equipped cutting machine tools. According to the invention, a laser beam (5) is supplied on the head-stock (17) of a machine tool (13), by means of a bea

Laser machining is often carried out using special machines or apparatus, with the workpieces having to be finished afterwards using appropriately equipped cutting machine tools. According to the invention, a laser beam (5) is supplied on the head-stock (17) of a machine tool (13), by means of a beam control tube (12). Said beam radiates into a focussing lens (35) at an articulation point (D). Said articulation point (D) is precisely guided and held in place in a centring cone (36) with its focussing lens (35) located underneath. The laser-machining head can be removed from the headstock (17) by means of a swivel mechanism and the machine (13) can carry out cutting operations in the usual way. The laser-machining operations are carried out before the cutting work in the processing cycle, a zero-offset being provided between the laser machining and the cutting work, correcting any system errors with the help of a computer.

대표청구항 ▼

Laser machining is often carried out using special machines or apparatus, with the workpieces having to be finished afterwards using appropriately equipped cutting machine tools. According to the invention, a laser beam (5) is supplied on the head-stock (17) of a machine tool (13), by means of a bea

Laser machining is often carried out using special machines or apparatus, with the workpieces having to be finished afterwards using appropriately equipped cutting machine tools. According to the invention, a laser beam (5) is supplied on the head-stock (17) of a machine tool (13), by means of a beam control tube (12). Said beam radiates into a focussing lens (35) at an articulation point (D). Said articulation point (D) is precisely guided and held in place in a centring cone (36) with its focussing lens (35) located underneath. The laser-machining head can be removed from the headstock (17) by means of a swivel mechanism and the machine (13) can carry out cutting operations in the usual way. The laser-machining operations are carried out before the cutting work in the processing cycle, a zero-offset being provided between the laser machining and the cutting work, correcting any system errors with the help of a computer. Summary in English). Stormann, et al. Arzneim. Forsch; 23; 1973; (Summary in English). Auterhoff, L. Lehrbuch der Pharmazeutischen Chemie. 12thEdition. Cole, B.M., et al. "Discovery of Chiral Catalysts through Ligand Diversity: Ti-Catalyzed Enantioselective Addition of TMSCN to meso Epoxides." Angew.. Chem. Int. Ed. Engl. 35(15): 1668-1671 (1996). Davis, P.W., et al. "Drug Leads from Combinatorial Phosphodiester Libraries." J. Med. Chem. 38: 4363-4366 (1995). Menger, F.M., et al. "Phosphatase Catalysis Developed via Combinatorial Organic Chemistry." J. Org. Chem. 60: 6666-6667 (1995). Pitha, J., et al. "Macromolecular B-adrenergic antagonists discriminating between receptor and antibody." Proc. Natl. Acad. Sci. USA. 77(4): 2219-2223 (1980). Kusiak, J.W., et al. "β-adrenergic pharmacores on the same molecule. A set of agonist-antagonist combinations." Biochem. Pharmacol. 36(2): 269-275 (1987). Zeng, et al. "Automated Analytical/Preparative High Performance Liquid Chromatography-Mass Spectrometry System for the Rapid Characterization and Purification of Compound Libraries." J. Chrom. A. 794:3-13 (1998). Alvarez, et al. J. Med. Chem. 30,7, 1186-1193 (1987). Barnes, P.J. "Current Therapies for Asthma." Chest 111:17S-26S (1997). Beck-Sickinger, A.G. "Structure Characterization and Binding sites of G-Protein-coupled Receptors." DDT, 1, 502-513 (1996). Carrithers, M., et al. "Synthesis and characterization of bivalent peptide ligands targeted to G-protein coupled receptors." Chem. and Biol. 3:537 (1996). Dupuis, DS., et al. "Magnitude of 5-HT1b and 5-HT1A receptor activation in guinea-pig rat brain: evidence from sumatriptan [35S]GTPγSbinding responses." Molecular Brain Research 67: 107-123 (1999).