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A flow-through vacuum degassing unit for degassing a mobile phase in liquid chromatography applications includes a relatively flat self-supporting thin membrane disposed in a compact degassing component, whereby the thin membrane is gas-permeable and liquid-impermeable to selectively degas a mobile

A flow-through vacuum degassing unit for degassing a mobile phase in liquid chromatography applications includes a relatively flat self-supporting thin membrane disposed in a compact degassing component, whereby the thin membrane is gas-permeable and liquid-impermeable to selectively degas a mobile phase. The self-supporting thin membrane is disposed on a permeable substrate through which a vacuum is drawn by a connected vacuum source. In a particular embodiment, the self-supporting membrane may be directly cast on the permeable substrate through a solvent-free thermal process.

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1. A degassing system, comprising: a degassing component having a degassing chamber therewithin, such a chamber being divided into first and second portions by a self-supporting film, said film being cast into the chamber without support structures as a gas-permeable and liquid-impermeable membra

1. A degassing system, comprising: a degassing component having a degassing chamber therewithin, such a chamber being divided into first and second portions by a self-supporting film, said film being cast into the chamber without support structures as a gas-permeable and liquid-impermeable membrane, and fluid inlet and outlet channels in fluid communication with the first portion, with the second portion being accessible from a vacuum source. 2. A degassing system as in claim 1 wherein said film is between about 5 micrometers and about 500 micrometers in thickness. 3. A degassing system as in claim 1 wherein said film is between about 10 micrometers and about 125 micrometers in thickness. 4. A degassing system as in claim 1 wherein said film comprises a perfluorinated copolymer. 5. A degassing system as in claim 4, including a liquid-impermeable diffusion layer disposed adjacent to said film between said film and said vacuum source. 6. A degassing system as in claim 5 wherein said film is at least partially adhered to said diffusion layer. 7. A degassing system as in claim 5 wherein said diffusion layer comprises a composite polymeric material. 8. A degassing system as in claim 5 wherein said diffusion layer comprises a ceramic material. 9. A method for creating a membrane degassing system, comprising: a) solvating perfluorinated copolymer in a solvent to form a first solution; b) drying said first solution to form a first membrane layer; c) solvating additional volume of perfluorinated copolymer in a solvent to form a second solution; d) heating said second solution to a gel state; e) coating said gel on a permeable substrate; f) pressing said first membrane layer against an upper surface of said gel such that said gel is disposed between said first membrane layer and said permeable substrate; and g) drying said gel, such that mechanical bonding is created between said first membrane layer and said permeable substrate to thereby form a self-supporting film disposed on said permeable substrate. 10. A method as in claim 9 wherein said gel is dried for about 24 hours at about 200° Celsius. 11. A method as in claim 9, wherein said self-supporting film is between about 5 and about 500 micrometers thick. 12. A method as in claim 9, including continuously pressing said first membrane layer against said upper surface of said gel throughout a time period associated with drying said gel. 13. A method for casting a self-supporting membrane in a degassing apparatus, comprising: a) heating perfluorinated copolymer to a temperature higher than its corresponding glass-transition temperature to create a molten copolymer; b) placing said molten copolymer on an upper surface of a permeable substrate; and c) allowing said molten copolymer to cool, thereby forming said self-supporting membrane. 14. A method as in claim 13, including pressing said molten copolymer against said permeable substrate to mechanically bond said membrane to said permeable substrate.