System and method for the production of autologous platelet gel
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B01D-021/26
A61K-035/16
출원번호
US-0833234
(2001-04-09)
발명자
/ 주소
Baugh, Robert F.
Lim, Lisa M.
Johnston, Julie S.
Rivera, John G.
Dolecek, Victor D.
출원인 / 주소
Medtronic, Inc.
대리인 / 주소
Petersen, Steven C.O'Rourke, Sarah S.Hogan & Hartson LLP
인용정보
피인용 횟수 :
97인용 특허 :
23
초록▼
A centrifuge system for the formation of an autologous platelet gel wherein all of the blood components for the gel are derived from a patient to whom the gel is to be applied. First a platelet rich plasma and a platelet poor plasma are formed by centrifuging a quantity of anticoagulated whole blood
A centrifuge system for the formation of an autologous platelet gel wherein all of the blood components for the gel are derived from a patient to whom the gel is to be applied. First a platelet rich plasma and a platelet poor plasma are formed by centrifuging a quantity of anticoagulated whole blood that was previously drawn from the patient. The platelet rich plasma or platelet poor plasma is then automatically drawn out of the centrifuge bag and proportioned into separate chambers in a dispenser. The first portion is activated where a clot is formed and thrombin is obtained. The thrombin is then latter mixed with the second portion to obtain a platelet gel.
대표청구항▼
A centrifuge system for the formation of an autologous platelet gel wherein all of the blood components for the gel are derived from a patient to whom the gel is to be applied. First a platelet rich plasma and a platelet poor plasma are formed by centrifuging a quantity of anticoagulated whole blood
A centrifuge system for the formation of an autologous platelet gel wherein all of the blood components for the gel are derived from a patient to whom the gel is to be applied. First a platelet rich plasma and a platelet poor plasma are formed by centrifuging a quantity of anticoagulated whole blood that was previously drawn from the patient. The platelet rich plasma or platelet poor plasma is then automatically drawn out of the centrifuge bag and proportioned into separate chambers in a dispenser. The first portion is activated where a clot is formed and thrombin is obtained. The thrombin is then latter mixed with the second portion to obtain a platelet gel. rained particles, the cyclone including: a body having a circumferential side wall extending between upper and lower ends and defining an interior space, the side wall comprising an upper wall portion and adjacent lower wall portion tapering inwardly in a direction away from the upper wall portion, the upper wall portion defining an inlet for introducing fluid and entrained particles into the interior space and the lower wall portion defining an underflow outlet extending in the direction of the longitudinal axis of the body for removing some fluid and entrained particles; and a vortex finder projecting substantially axially into the interior space through the upper end of the body and terminating at an internal end positioned below the inlet, the vortex finder defining an overflow outlet which removes the remaining fluid and entrained particles from the cyclone; wherein the vortex finder and the upper wall portion are configured to define a feed zone of decreasing cross sectional area from the inlet to the internal end of the vortex finder. 2. A cyclone according to claim 1, wherein the vortex finder defines an outer wall surface that tapers outwardly from the inlet to the internal end of the vortex finder. 3. A cyclone according to claim 2, wherein the outer wall surface of the vortex finder tapers outwardly from the upper end of the body to the internal end of the vortex finder. 4. A cyclone according to claim 3, wherein the vortex finder tapers outwardly at an angle of 83° to 88° relative to an axis extending orthogonally to the longitudinal axis of the body. 5. A cyclone according to claim 4, wherein the ratio of the diameter of the outer wall of the vortex finder at the internal end of the vortex finder to the diameter of the aligned upper wall portion of the body is 0.65 to 0.85. 6. A cyclone according to claim 2, wherein the diameter of the outlet defined in the vortex finder is less than one half of the diameter of the outer wall surface of the vortex finder at the internal end of the vortex finder. 7. A cyclone according to claim 1, wherein the thickness of the outer wall of the vortex finder is 17%-23% of the diameter of the body of the cyclone at a position aligned with the internal end of the vortex finder. 8. A cyclone according to claim 1, wherein the upper wall portion tapers radially inwardly in a longitudinal direction away from the inlet. 9. A cyclone according to claim 8, wherein the upper wall portion tapers inwardly at an angle of 3° to 10° relative to the longitudinal axis of the body. 10. A cyclone according to claim 1, wherein the lower wall portion tapers inwardly away from the upper wall portion at an angle of 4° to 10° relative to the longitudinal axis of the body for fine particle separation. 11. A cyclone according to claim 1, wherein the lower wall portion defines a formation projecting inwardly into the interior space of the body substantially transverse to the longitudinal axis of the body. 12. A cyclone according to claim 11, wherein the formation is a shoulder extending substantially fully around the circumference of the lower wall portion. 13. A cyclone according to claim 12, wherein the shoulder has a depth of 1 mm to 5 mm or the shoulder has a depth of 3% to 6% of the diameter of the underflow outlet. 14. A cyclone according to claim 13, wherein the lower wall portion forms a spigot adjacent the lower end of the body and the shoulder is formed proximate the spigot. 15. A cyclone for effecting a separation on a fluid stream containing entrained particles, the cyclone including a body having a circumferential side wall extending between upper and lower ends and defining an interior space, the side wall comprising an upper wall portion and adjacent lower wall portion tapering inwardly in a direction away from the upper wall portion, the upper wall portion defining an inlet for introducing fluid and entrained particles into the interior space and the lower wall portion defining an underflow outlet extending in the direction of the longitudinal axis of the body for removing some fluid and entrained particles; and a vortex finder projecting substantially axially into the interior space through the upper end of the body and terminating at an internal end positioned below the inlet, the vortex finder defining an overflow outlet which removes the remaining fluid and entrained particles from the cyclone; wherein the vortex finder flares outwardly from the upper end of the body to its internal end and occupies at least 40% of the cross sectional area of the body of the cyclone at a position aligned with the internal end of the vortex finder. 16. A cyclone according to claim 15, wherein the vortex finder occupies between 40% and 60% of the cross sectional area of the body of the cyclone at a position aligned with the internal end of the vortex finder. 17. A cyclone according to claim 16, wherein the vortex finder occupies between 40% and 55% of the cross sectional area of the body of the cyclone at a position aligned with the internal end of the vortex finder. 18. A cyclone for effecting a separation on a fluid stream containing entrained particles, the cyclone including a body having a circumferential side wall extending between upper and lower ends and defining an interior space, the side wall comprising an upper wall portion and adjacent lower wall portion tapering inwardly in a direction away from the upper wall portion, the upper wall portion defining an inlet for introducing fluid and entrained particles into the interior space and the lower wall portion defining an underflow outlet extending in the direction of the longitudinal axis of the body for removing some fluid and entrained particles; and a vortex finder projecting substantially axially into the interior space through the upper end of the body and terminating at an internal end positioned below the inlet, the vortex finder defining an overflow outlet which removes the remaining fluid and entrained particles from the cyclone; wherein the lower wall portion includes a formation extending radially inwardly into the interior space substantially perpendicular to the longitudinal axis. 19. A cyclone according to claim 18, wherein the formation is a shoulder extending substantially fully around the circumference of the lower wall portion, and the shoulder is positioned adjacent to the underflow outlet. 20. A cyclone according to claim 19, wherein the shoulder has a depth of 1 mm to 5 mm. 21. A cyclone for effecting a separation on a fluid stream containing entrained particles, the cyclone including a body having a circumferential side wall extending between upper and lower ends and defining an interior space, the side wall comprising an upper wall portion and adjacent lower wall portion tapering inwardly in a direction away from the upper wall portion, the upper wall portion defining an inlet for introducing fluid and entrained particles into the interior space and the lower wall portion defining an underflow outlet extending in the direction of the longitudinal axis of the body for removing some fluid and entrained particles; and a vortex finder projecting substantially axially into the interior space through the upper end of the body and terminating at an internal end positioned below the inlet, the vortex finder defining an overflow outlet which removes the remaining fluid and entrained particles from the cyclone; wherein the vortex finder defines an outer wall surface which tapers outwardly from the upper end of the body towards its internal end and the upper wall portion also tapers radially inwardly in a longitudinal direction from the inlet towards the lower wall portion. 22. A cyclone according to claim 21, wherein the outer wall surface of the vortex finder tapers outwardly at an angle of 83° to 88° to an axis extending perpendicularly to the longitudinal axis through the body of the cyclone. 23. A dense media cyclone fo
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