Infant formula and methods of improving infant stool patterns
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/20
A23D-009/00
출원번호
US-0789035
(2001-02-20)
발명자
/ 주소
Masor, Marc L.
Ponder, Debra L.
Benson, John D.
Katz, Gary E.
출원인 / 주소
Abbott Laboratories
대리인 / 주소
Winter, William J.
인용정보
피인용 횟수 :
17인용 특허 :
19
초록▼
The invention is directed to an improved infant formula containing a lipid blend that softens the firmer stools associated with typical infant formula. A specific formula in accordance with the invention comprises carbohydrates, proteins, vitamins and minerals and a lipid mixture of high oleic saffl
The invention is directed to an improved infant formula containing a lipid blend that softens the firmer stools associated with typical infant formula. A specific formula in accordance with the invention comprises carbohydrates, proteins, vitamins and minerals and a lipid mixture of high oleic safflower oil, soy oil and coconut oil at specific levels and ratios. The invention also discloses novel mixtures of fatty acids that provides infant stool patterns more closely resembling the breast-fed infant.
대표청구항▼
The invention is directed to an improved infant formula containing a lipid blend that softens the firmer stools associated with typical infant formula. A specific formula in accordance with the invention comprises carbohydrates, proteins, vitamins and minerals and a lipid mixture of high oleic saffl
The invention is directed to an improved infant formula containing a lipid blend that softens the firmer stools associated with typical infant formula. A specific formula in accordance with the invention comprises carbohydrates, proteins, vitamins and minerals and a lipid mixture of high oleic safflower oil, soy oil and coconut oil at specific levels and ratios. The invention also discloses novel mixtures of fatty acids that provides infant stool patterns more closely resembling the breast-fed infant. B>and X2together form =O; R1is (1) hydrogen or R6, where R6is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, heterocyclo, or heterocycloalkyl, each of which is unsubstituted or substituted with Z1,Z2and one or more groups Z3; (2) --OH or --OR6; (3) --SH or --SR6; (4) --C(O)2H, --C(O)qR6,or --O--C(O)qR6,where q is 1 or 2; (5) --SO3H or --S(O)qR6; (6) halo; (7) cyano; (8) nitro; (9) --Z4--NR7R8; (10) --Z4--N(R9)--Z5--NR10R11; (11) --Z4--N(R12)--Z5--R6; (12) --P(O)(OR6)2; R2is hydrogen, R6,--Z4--R6,or --Z13--NR7R8; R3is --Z4--R6wherein Z4is a single bond and wherein R6is aryl substituted with at least one group Z3 where Z3is --Z4--NZ7Z8where Z4is a bond Z7is hydrogen or alkyl and Z8is heterocyclo-substituted alkyl; R4and R5are each independently (1) hydrogen or R6; (2) --Z4--N(R9)--Z5--NR10R11; (3) --N(R9)Z4R6; or (4) together with the nitrogen atom to which they are attached complete a 3- to 8-membered saturated or unsaturated heterocyclic ring which is unsubstituted or substituted with Z1,Z2and Z3,which heterocyclic ring may optionally have fused to it a benzene ring itself unsubstituted or substituted with Z1,Z2and Z3; R7,R8,R9,R10,R11and R12 (1) are each independently hydrogen or R6; (2) R7and R8may together be alkylene, alkenylene or heteroalkyl, completing a 3- to 8-membered saturated or unsaturated ring with the nitrogen atom to which they are attached, which ring is unsubstituted or substituted with Z1,Z2and Z3; or (3) any two of R9,R10and R11may together be alkylene or alkenylene completing a 3- to 8-membered saturated or unsaturated ring together with the nitrogen atoms to which they are attached, which ring is unsubstituted or substituted with Z1,Z2and Z3; R13is (1) cyano; (2) nitro; (3) --NH2; (4) --NHOalkyl; (5) --OH; (6) --NHOaryl; (7) --NHCOOalkyl; (8) --NHCOOaryl; (9) --NHSO2alkyl; (10) --NHSO2aryl; (11) aryl; (12) heteroaryl; (13) --Oalkyl; or (14) --Oaryl; R14is (1) --NO2; (2) --COOalkyl; or (3) --COOaryl; R15is (1) hydrogen; (2) alkyl; (3) aryl; (4) arylalkyl; or (5) cycloalkyl; Z1,Z2and Z3are each independently (1) hydrogen or Z6,where Z6is (i) alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, alkylaryl, cycloalkylaryl, heterocyclo, or heterocycloalkyl; (ii) a group (i) which is itself substituted by one or more of the same or different groups (i); or (iii) a group (i) or (ii) which is substituted by one or more of the following groups (2) to (16) of the definition of Z1,Z2and Z3; (2) --OH or --OZ6; (3) --SH or --SZ6; (4) --C(O)qH, --C(O)qZ6,or --O--C(O)qZ6; (5) --SO3H, --S(O)qZ6; or S(O)qN(Z9)Z6; (6)
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