초록 ▼

An oral pharmaceutical modified release multiple-units composition for the administration of a therapeutically and/or prophylactically effective amount of a non-steroid anti-inflammatory drug substance to obtain both a relatively fast onset of the therapeutic effect and the maintenance of a therapeu

An oral pharmaceutical modified release multiple-units composition for the administration of a therapeutically and/or prophylactically effective amount of a non-steroid anti-inflammatory drug substance to obtain both a relatively fast onset of the therapeutic effect and the maintenance of a therapeutically active plasma concentration for a relatively long period of time is disclosed.

대표청구항 ▼

An oral pharmaceutical modified release multiple-units composition for the administration of a therapeutically and/or prophylactically effective amount of a non-steroid anti-inflammatory drug substance to obtain both a relatively fast onset of the therapeutic effect and the maintenance of a therapeu

An oral pharmaceutical modified release multiple-units composition for the administration of a therapeutically and/or prophylactically effective amount of a non-steroid anti-inflammatory drug substance to obtain both a relatively fast onset of the therapeutic effect and the maintenance of a therapeutically active plasma concentration for a relatively long period of time is disclosed. Mucin composition in primates, 1985.* Madara, JL et al, Gastroenterology, vol. 88, pp. 13-19, 1985.* Dielman, LA et al, Gastroenterology, vol. 114(4 of part 2), pp. A965, Apr. 15, 1998(abstract).* Kullberg, MC et al;, Infection Immunity, vol. 66(11), pp. 5157-5166, Nov. 1998 (abstract).* Sartor, RB, Gastroenterology clinics of North America, vol. 24(3), pp. 475-507, Sep. 1995.* Wakefield, AJ et al, Gastroenterology, vol. 108(3), Mar. 1995, pp. 911-916, (abstract).* Maehlen, J et al, Tidsskr Nor Laegeforen, Sep. 1997, vol. 117(22), pp. 3262-3263, (abstract).* Braegger, CP, ACTA Paediatr. suppl. (Norway), Apr. 1994, vol. 83(395), pp. 18-21 (abstract).* Macpherson, A et al, Gut, Mar. 1996, vol. 38(3), pp. 365-375, (abstract).* Heap, K et al, Microb. Ecol. Health Dis, vol. 4, abstract S119, Oct. 7-10, 1991.* Dunkley, ML et al, Microb. Ecol. Health Dis. vol. 4(spec. issue), p. S148, abstract, Oct. 7-10, 1991.* Chen, M et al, Gastroenterology, vol. 104(14), Apr. 1993, p. 681, col. 1, bottom of col., abstract only.* Monath, TP et al, American Journal of Gastroneterology, vol. 89, p. 1383, abstract No. 393, Aug. 1994.* Varga Laszlo et al, Kazuisztika, pp. 359-361, Issue 6, 1992, Helicobacter pylori allergia, (English translation) 1992.* Tomb, JF et al, Nature, vol. 388, pp. 539-547, Aug. 1997.* James, SP et al, Aliment Pharmacol. Ther. vol. 10(suppl. 2), pp. 1-9, (abstract) 1996.* Duchmann, R et al, Eur. J. Immunol., Apr. 1996, vol. 26(4), pp. 934-936, 1995.* Cahill et al, Gastroenterology, vol. 110 (4 suppl), p. A875, 1996.* Mayer, D et al, Gastroenterology, vol. 110 (4) Apr., p. 960, 1996.* Cahill et al, Gut, vol. 39, (Suppl. 2) p. A78, abstract No. 3B:123, 1996.* Halme et al, Gut, Mar. 1996, vol. 38(3), pp. 379-383, Mar.* Ruuska, T. et al, Journal of Pediatric Gastroenterology and Nutrition, Aug. 1994, vol. 19(2), pp. 181-186,(abstract).* Foltz, C.J. et al, Laboratory Animal Science, vol. 46(2), pp. 193-197, (abstract), 1996.* Czinn et al, Infection and Innumity, pp. 2359-2363, 1991.* Czinn et al, Vaccine, vol. 11 (6), pp. 637-638, 1993.* Pappo et al, Infection and Immunity, Apr. 1995, pp. 1246-1252, vol. 63(4).* Cuenca et al, Gastroenterology, vol. 110, pp. 1770-1775, 1996.* Davin, C et al, Gastroenterology, vol. 104(4), Apr., p. A1035, (abstract) 1993.* Corthesy-Theulaz et al, Gastroenterology, vol. 109, pp. 115-121, 1995.* "Cecil's Textbook of Medicine" Eds. Wyngaarden and Smith, W.B. Saunders Co.: 1985. The Merck Manual of Diagnosis and Therapy. Merck Sharp & Dohme Research Laboratories: 1982. "Harrison's Principles of Internal Medicine", 12th Ed. McGraw-Hill, Inc.: 1991. "Inflammatory Bowel Disease", Eds. Kirsner, J.B. et al. 3rd ed Philadelphia:Lea and Febiger, 1988. "Digestive Diseases And Sciences", Ed. Zipser, R.D., 33 Suppl.: 1S-87S: 1988. Engstrand, L. "Potential Animal Models of Helicobacter pylori Infection In Immunological And Vaccine Research," FEMS Immunology and Medical Microbiology 10:265-270, 1995. Ferrero, R. et al., "Local Immunoglobulin G Antibodies In The Stomach May Contribute To Immunity Against Helicobacter Infection In Mice," Gastroenterology 112:185-194, 1997. Lee and Chen, "Successful Immunication Against Gastric Infection With Helicobacter Species: Use Of A Cholera Toxin B-Subunit-Whole-Cell Vaccine," Infection and Immunity 3594-3597, Aug. 1994. Weltzin, et al., "Generation Of Systemic And Mucosal Antibody Responses By Repeated Intranasal Immunization Without Adjuvant," FASEB 9:A216, 1995. Weltzin, et al., "Novel Intranasal Immunization Techniques For Antibody Induction And Protection Of Mice Against Gastric Helicobacter felis Infection," Vaccine 15:370-376, 1997. es suitable for use in such treatment.