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A communication system 100 includes a plurality of controller stations 114 and 116, and at least one controlled station 104 to 112. The stations are interconnected via a communication network 120. The functionality of each controlled station is associated with a respective abstract representation, r

A communication system 100 includes a plurality of controller stations 114 and 116, and at least one controlled station 104 to 112. The stations are interconnected via a communication network 120. The functionality of each controlled station is associated with a respective abstract representation, referred to as AR. The AR provides an interface for software elements in the system to control functionality of the controlled station by means of messages exchanged with the AR via the communication network. The AR may be implemented using platform-independent code, such as Java. Each controller station includes control means for executing at least one AR of a controlled station and assigned to the local controller station. The system includes leader selection means for selecting a single one of the controller stations as a leading controller station. AR distribution means of the leading controller station determines which controller station should preferably execute the AR(s) of the respective controlled station(s) and assigns each AR to at most to one of the controller stations.

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A communication system 100 includes a plurality of controller stations 114 and 116, and at least one controlled station 104 to 112. The stations are interconnected via a communication network 120. The functionality of each controlled station is associated with a respective abstract representation, r

A communication system 100 includes a plurality of controller stations 114 and 116, and at least one controlled station 104 to 112. The stations are interconnected via a communication network 120. The functionality of each controlled station is associated with a respective abstract representation, referred to as AR. The AR provides an interface for software elements in the system to control functionality of the controlled station by means of messages exchanged with the AR via the communication network. The AR may be implemented using platform-independent code, such as Java. Each controller station includes control means for executing at least one AR of a controlled station and assigned to the local controller station. The system includes leader selection means for selecting a single one of the controller stations as a leading controller station. AR distribution means of the leading controller station determines which controller station should preferably execute the AR(s) of the respective controlled station(s) and assigns each AR to at most to one of the controller stations. , Gln, Glu, Pro or Ser; d. when a substitution occurs at position 63, the substituting amino acid is Asn, Asp, Gln, Glu, Pro or Ser; and e. when a substitution occurs at position 64, the substituting amino acid is Asn, Asp, Gln, Glu, Gly, Pro Ser; B. when a substitution occurs in the second loop region, the substitution occurs at one or more of positions 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104 or 105; wherein a. when substitution occurs at position 93, the substituting amino acid is Ala, Asn, Asp, Cys, Gln, Glu, Gly, His, Met, Pro, Ser or Thr; b. when a substitution occurs at position 94, the substituting amino acid is Ala, Asn, Asp, Cys, Gln, Glu, Gly, His, Ile, Met, Pro, Ser, Thr or Val; c. when a substitution occurs at position 95, the substituting amino acid is Asn, Asp, Gln, Glu, Pro or Ser; provided that if position 96 or position 207 is substituted with Asp, and the variant is a double mutation variant, then position 95 is not substituted with Asp; and when position 95 is substituted the variant is not a double, triple, quadruple, quintuple, sextuple, or septuple mutation variant having substitution at position selected from the group consisting of 102, 153, 154, 160, 183, and 211; d. when a substitution occurs at position 96, the substituting amino acid is Asn, Asp, Gln, Glu, Gly, His, Pro, Ser or Thr; provided that if position 207 is substituted with Asp, and the variant is a double mutation variant, then position 96 is not substituted with Asp; and when position 96 is substituted the variant is not a double, triple, quadruple, quintuple, or sextuple mutation variant having a substitutions at positions selected from the group consisting of 102, 154, 160, 183, and 211; e. when a substitution occurs at position 97, the substituting amino acid is Asp or Glu; but when position 97 is substituted the variant is not a double, triple, quadruple, quintuple, or sextuple mutation variant having a substitutions at positions selected from the group consist