IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0885693
(2001-06-20)
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발명자
/ 주소 |
- Villagran, Francisco Valentino
- Dria, Glenn James
- Young, Herbert Thomas
- Baughman, John Michael
- Chen, Jing
|
출원인 / 주소 |
- The Procter & Gamble Company
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대리인 / 주소 |
Hemm, Erich D.Chuey, S. RobertRoof, Carl J.
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인용정보 |
피인용 횟수 :
49 인용 특허 :
25 |
초록
▼
Insoluble, denatured, heat-stable protein particles are used in food and beverage products. The particles are easily dispersible in aqueous solutions and take the form of substantially non-aggregated macro-colloids. In a hydrated state the preferred mean diameter particle size distribution of the in
Insoluble, denatured, heat-stable protein particles are used in food and beverage products. The particles are easily dispersible in aqueous solutions and take the form of substantially non-aggregated macro-colloids. In a hydrated state the preferred mean diameter particle size distribution of the insoluble, denatured, heat-stable particles ranges from about 0.1 microns to about 3.0 microns, with less than about 5 percent of the total number of particles exceeding about 3.0 microns in diameter. The majority of the particles are substantially spheroidal in shape and have a substantially smooth, emulsion-like organoleptic character similar to that of high-calorie fats and oils. Additionally, these particles have a degree of protein insolubility of at least about 80%, which provides processing advantages during heat treatment.
대표청구항
▼
Insoluble, denatured, heat-stable protein particles are used in food and beverage products. The particles are easily dispersible in aqueous solutions and take the form of substantially non-aggregated macro-colloids. In a hydrated state the preferred mean diameter particle size distribution of the in
Insoluble, denatured, heat-stable protein particles are used in food and beverage products. The particles are easily dispersible in aqueous solutions and take the form of substantially non-aggregated macro-colloids. In a hydrated state the preferred mean diameter particle size distribution of the insoluble, denatured, heat-stable particles ranges from about 0.1 microns to about 3.0 microns, with less than about 5 percent of the total number of particles exceeding about 3.0 microns in diameter. The majority of the particles are substantially spheroidal in shape and have a substantially smooth, emulsion-like organoleptic character similar to that of high-calorie fats and oils. Additionally, these particles have a degree of protein insolubility of at least about 80%, which provides processing advantages during heat treatment. e improvement of claim 29, wherein the polypeptide is a tumor necrosis factor. 31. The improvement of claim 23, wherein the polypeptide is selected from the group consisting of interferons, interleukins, erythropoietin, granulocyte stimulating factor, growth factors, and enzymes. 32. The improvement of claim 23, wherein R5is H and R2is selected from the group consisting of H, CH3,C2H5and C3H8. 33. The improvement of claim 23, wherein R2and R5are alkyls. 34. A method for improving the blood circulation lifetime of a polypeptide, comprising preparing a polymer-polypeptide conjugate having the general structure: wherein R1is the hydrophilic polymer comprising a linkage for attachment to the dithiobenzyl moiety; R2is selected from the group consisting of H, alkyl and aryl; R3is selected from the group consisting of O(C=O), S(C=O), and O(C=S); R4is the polypeptide; and R5is selected from the group consisting of H, alkyl and aryl; where orientation of CH2--R3is selected from the ortho position and the para position; and n is at least 1. 35. The method of claim 34, wherein n is between about 1 and about 6. 36. The method of claim 34, wherein said hydrophilic polymer R1is selected from the group consisting of polyvinylpyrrolidone, polyvinylmethylether, polymethyloxazoline, polyethyloxazoline, polyhydroxypropyloxazoline, polyhydroxypropyl-methacrylamide, polymethacrylamide, polydimethyl-acrylamide, polyhydroxypropylmethacrylate, polyhydroxyethylacrylate, hydroxymethylcellulose, hydroxyethylcellulose, polyethyleneglycol, polyaspartamide, copolymers thereof, and polyethyleneoxide-polyprop
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