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Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12P-021/08
  • A61K-039/40
  • A61K-039/395
출원번호 US-0097055 (1998-06-15)
발명자 / 주소
  • Fischer, Gerald W.
  • Schuman, Richard F.
  • Wong, Hing
  • Stinson, Jeffrey R.
출원인 / 주소
  • The Henry M. Jackson Foundation for the Advancement of Military Medicine, Sunol Molecular Corporation
대리인 / 주소
    Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
인용정보 피인용 횟수 : 41  인용 특허 : 28

초록

The present invention encompasses monoclonal and chimeric antibodies that bind to lipoteichoic acid of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro and enhance protection from lethal infection in vivo. The mouse mono

대표청구항

The present invention encompasses monoclonal and chimeric antibodies that bind to lipoteichoic acid of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro and enhance protection from lethal infection in vivo. The mouse mono

이 특허에 인용된 특허 (28)

  1. Kiselev Anatoly Efimovich (ULITSA Kostyakova ; 8/6 ; kv. 182 Moscow SU) Skurkovich Semen Vladimirovich (Frunzensky val ; 38 ; kv. 103 Moscow SU) Golosova Tatyana Vasilievna (ULITSA B. Gruzinskaya ; 6, Antistaphylococcous human immunoglobulin and method of preparing same.
  2. Norcross Neil L. (Ithaca NY) Opdebeeck Johanna P. (Ithaca NY), Bovine mastitis vaccine and method for detecting efficacy thereof.
  3. Fischer Gerald W. (Bethesda MD), Broadly reactive opsonic antibodies that react with common staphylococcal antigens.
  4. Pier Gerald B. (Brookline MA), Capsular polysaccharide adhesin antigen, preparation, purification and use.
  5. Curry Willie M. (New Rochelle NY) Farb David L. (LaGrangeville NY), Composition of intravenous immune globulin.
  6. Curry Willie M. (New Rochelle NY) Farb David L. (LaGrangeville NY), Composition of intravenous immune globulin.
  7. Frank Robert (Strasbourg FRX) Klein Jean P. (Breuschwickersheim FRX) Ackermans Fabienne (Brussels BEX) Bazin Herv (Brussels BEX), Conjugate constituted from a wall adhesin of S. mutans of proteinic nature and from a polysaccharide of 상세보기
  • Carroll Sean B. (Cottage Grove WI) Firca Joseph R. (Vernon Hills IL) Pugh Charles (Madison WI) Padhye Nisha V. (Madison WI), Conjugates for the prevention and treatment of sepsis.
  • Marburg Stephen (Metuchen NJ) Tolman Richard L. (Warren NJ) Jorn Deborah A. (Metuchen NJ), Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogeni.
  • Hk Magnus (Birmingham AL) Jnsson Klas (Studentvgen SEX) Lindberg Kjell M. (Kornvgen SEX) Signs Christer (Hamnesplanaden SEX), DNA encoding a fibronectin binding protein as well as its preparation.
  • Fischer Gerald W., Directed human immune globulin for the prevention and treatment of staphylococcal infections.
  • Hk Magnus (129 Stevens Hill Cir. Birmingham AL 35244) McGavin Martin (1717 Beacon Crest Cir. Birmingham AL 35209) Raucci Guiseppe (Via Tito Speri 10 I-00040 Pomezia ; Rome ITX), Fibronectin binding peptide.
  • Hook Magnus (Birmigham AL) Jonsson Klas (Studentvagen SEX) Lindberg Kjell Martin (Kornvagen SEX) Signas Christer (Hamnesplanaden SEX), Fibronectin binding protein.
  • Hook Magnus ; Jonsson Klas,SEX ; Lindberg Kjell Martin,SEX ; Signas Christer,SEX, Fibronectin binding protein as well as its preparation.
  • Burnham Martin Karl Russel,GBX ; Chopra Ian,GBX ; Critchley Ian Alfred,GBX ; Knowles David Justin Charles,GBX, Fibronectin binding protein polypeptides.
  • Ligler Frances S. (Potomac MD) Whelan James P. (Potomac MD), Lyophilized ligand-receptor complexes for assays and sensors.
  • Gristina Anthony G. (Reston VA) Myrvik Quentin N. (Caswell Beach NC), Method and compositions for the direct concentrated delivery of passive immunity.
  • Krieger Monty (Needham MA) Joiner Keith A. (New Haven CT), Method for treating gram positive septicemia.
  • Emery Daryll A. (Willmar MN) Straub Darren E. (Willmar MN) Huisinga Richard (Willmar MN), Method of priming an immune response in a one-day old animal.
  • Gristina Anthony G. (11605 Deer Forest Rd. Reston VA 22094) Myrvik Quentin N. (404 Palmetto Dr. Caswell Beach NC 28465), Methods and compositions for the direct concentrated delivery of passive immunity.
  • Jolivet-Reynaud Colette,FRX, Mimotopic polypeptides of Toxoplasma gondii and applications.
  • Porro Massimo (Siena ITX), Oligosaccharide conjugate vaccines.
  • Stolle Ralph J. (Lebanon OH) Beck Lee R. (Birmingham AL), Prevention and treatment of rheumatoid arthritis.
  • Fournier Jean-Michel (Paris FRX) Bouvet Anne (Paris FRX) Boutonnier Alain (Paris FRX), Process for the preparation of capsular polysaccharides of staphylococci, the polysaccharides obtained, uses of these po.
  • Proctor, Richard A., Staphylococcal fibronectin receptor, monoclonal antibodies thereto and methods of use.
  • Fattom Ali Ibrahim ; Patel Atulkumar Induprasad, Staphylococcus aureus B-linked hexosamine antigen.
  • d\Hinterland Lucien D. (Castres FRX) Normier Grard (Castres FRX) Pinel Anne-Marie (Castres FRX) Durand Jacques (Castres FRX), Vaccinal complex containing a specific antigen and vaccine containing it.
  • Yoshida Kosaku (2095 Sugao ; Takatu-ku ; Kawasaki ; Kanegawa-ken 213 JPX), Vaccine.
  • 이 특허를 인용한 특허 (41)

    1. Theuer, Charles, Anti-endoglin antibodies and uses thereof.
    2. Theuer, Charles, Anti-endoglin antibodies and uses thereof.
    3. Jiao, Jin-an; Wong, Hing C.; Nieves, Esperanza Liliana; Mosquera, Luis A., Anti-tissue factor antibodies and methods of use thereof.
    4. Jiao, Jin-an; Wong, Hing C.; Wen, Jinghai, Antibodies for inhibiting blood coagulation and methods of use thereof.
    5. Benedict, Suzanne; Manning, Mark Cornell; Murphy, Brian M.; Real, Sharon; Theuer, Charles, Antibody formulations and uses thereof.
    6. Fischer, Gerald W.; Daum, Luke T., Biological specimen collection and transport system.
    7. Fischer, Gerald W.; Daum, Luke T., Biological specimen collection and transport system and method of use.
    8. Fischer, Gerald W.; Daum, Luke T., Biological specimen collection and transport system and method of use.
    9. Fischer, Gerald W; Daum, Luke T., Biological specimen collection and transport system and method of use.
    10. Fischer, Gerald W.; Daum, Luke T., Biological specimen collection and transport system and methods of use.
    11. Fischer, Gerald W.; Daum, Luke T., Biological specimen collection/transport compositions and methods.
    12. Fischer, Gerald W.; Daum, Luke T., Composite antigenic sequences and vaccines.
    13. Fischer, Gerald W.; Daum, Luke T., Composite antigenic sequences and vaccines.
    14. Fischer, Gerald W.; Daum, Luke T., Compositions and methods for detecting and identifying nucleic acid sequences in biological samples.
    15. Fischer, Gerald W.; Daum, Luke T., Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids.
    16. Fischer, Gerald W.; Daum, Luke T., Compositions and methods for rapid, real-time detection of influenza a virus (H1N1) Swine 2009.
    17. Theuer, Charles; Vasquez, Maximiliano, Endoglin antibodies.
    18. Theuer, Charles; Vasquez, Maximiliano, Endoglin antibodies.
    19. Theuer, Charles; Vasquez, Maximiliano, Endoglin antibodies.
    20. Theuer, Charles; Vasquez, Maximiliano, Endoglin antibodies.
    21. Theuer, Charles; Vasquez, Maximiliano, Endoglin antibodies.
    22. Fischer,Gerald Walter; Schuman,Richard F.; Wong,Hing; Stinson,Jeffrey R., Humanized and chimeric antibodies specific for lipoteichoic acid of GRAM positive bacteria.
    23. Fischer, Gerald W.; Daum, Luke T., Immunogenic compositions and methods.
    24. Fischer, Gerald W.; Daum, Luke T., Immunogenic compositions and methods.
    25. Koulchin, Vladimir A.; Moore, Norman J.; Molokova, Elena V., Method for detection of Legionella bacteria employing purified antigen-specific antibodies.
    26. Wong, Hing C.; Jiao, Jin-An; Nieves, Esperanza Liliana; Luepschen, Lawrence, Method for using antibodies for inhibiting blood coagulation.
    27. Schuman,Richard F.; Kokai Kun,John Fitzgerald; Foster,Simon J.; Stinson,Jeffrey R.; Fischer,Gerald Walter, Multifunctional monoclonal antibodies directed to peptidoglycan of gram-positive bacteria.
    28. Fischer, Gerald W.; Schuman, Richard F., Multimodal antimicrobial therapy.
    29. Stinson, Jeffrey R.; Schuman, Richard F.; Mond, James Jacob; Lees, Andrew; Fischer, Gerald Walter, Nucleic acids encoding opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria.
    30. Fischer, Gerald W.; Schuman, Richard F.; Wong, Hing; Stinson, Jeffrey R., Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram posiive bacteria.
    31. Fischer, Gerald W.; Schuman, Richard F.; Wong, Hing; Stinson, Jeffrey R., Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria.
    32. Stinson,Jeffrey R.; Schuman,Richard F.; Mond,James J.; Lees,Andrew; Fischer,Gerald Walter, Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of Gram positive bacteria.
    33. Fischer, Gerald Walter; Schuman, Richard F.; Wong, Hing; Stinson, Jeffrey R., Polynucleotides encoding humanized and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria.
    34. Moore, Norman J.; Konstantin, Mary K.; Koulchin, Vladimir A.; Molokova, Elena V., Process and materials for the rapid detection of Streptococcus pneumoniae employing purified antigen-specific antibodies.
    35. Fischer, Gerald W.; Daum, Luke T., Rapid methods for the extraction of nucleic acids from biological samples.
    36. Fischer, Gerald W.; Daum, Luke T., Rapid methods for the extraction of nucleic acids from biological samples.
    37. Donald, Robert G. K.; Kodali, Srinivas; Vinogradov, Evguenii, Saccharides and uses thereof.
    38. Otto, Michael; Kocianova, Stanislava, Targeting poly-gama-glutamic acid to treat Staphylococcus epidermidis and related infections.
    39. Otto, Michael; Kocianova, Stanislava, Targeting poly-gamma-glutamic acid to treat Staphylococcus epidermidis and related infections.
    40. Otto, Michael; Kocianova, Stanislava; Vuong, Cuong; Voyich, Jovanka; Yao, Yufeng; Fischer, Elizabeth; De Leo, Frank, Targeting poly-γ-glutamic acid to treat Staphylococcus epidermidis and related infections.
    41. Jiao, Jin-An; Wong, Hing C.; Nieves, Esperanza Liliana; Mosquera, Luis A., Use of anti-tissue factor antibodies for treating thromboses.

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