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A dialyzer is provided comprising a casing defining an interior and including a dialysate inlet and a dialysate outlet. A plurality of fibers are located in the interior of the casing and define a fiber bundle. A dialysate inlet fluid channel is provided in fluid communication with the dialysate inl

A dialyzer is provided comprising a casing defining an interior and including a dialysate inlet and a dialysate outlet. A plurality of fibers are located in the interior of the casing and define a fiber bundle. A dialysate inlet fluid channel is provided in fluid communication with the dialysate inlet and includes a plurality of flutes that extend into a portion of the fiber bundles, the flutes define an opening for allowing dialysate to flow from the inlet fluid channel into the interior of the casing. Methods of providing dialysis are also provided.

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A dialyzer is provided comprising a casing defining an interior and including a dialysate inlet and a dialysate outlet. A plurality of fibers are located in the interior of the casing and define a fiber bundle. A dialysate inlet fluid channel is provided in fluid communication with the dialysate inl

A dialyzer is provided comprising a casing defining an interior and including a dialysate inlet and a dialysate outlet. A plurality of fibers are located in the interior of the casing and define a fiber bundle. A dialysate inlet fluid channel is provided in fluid communication with the dialysate inlet and includes a plurality of flutes that extend into a portion of the fiber bundles, the flutes define an opening for allowing dialysate to flow from the inlet fluid channel into the interior of the casing. Methods of providing dialysis are also provided. conditions, to produce a first stage effluent comprising (i) a liquid boiling in the diesel fuel range reduced in heteroatom compounds and (ii) a vapor containing vaporous heteroatom species produced by the reaction; b) passing said first stage effluent to a stripping stage wherein it is contacted with a stripping gas to form a stripped first stage liquid effluent and a stripping stage vapor effluent comprised of the first reaction stage vapor and said stripping gas; c) removing said stripping stage vapor effluent; d) passing said stripped liquid into a second reaction stage reaction stage operated in a cocurrent manner, where the stripped liquid reacts with hydrogen treat gas under second stage catalytic conversion conditions, in the presence of a second catalyst selective for aromatics removal, to remove aromatic compounds and produce second stage liquid and vapor effluents, wherein said vapor contains unreacted hydrogen and said liquid comprises a diesel boiling-range hydrocarbon having a heteroatom and aromatics content lower than that of said feed; e) separating the second stage liquid and vapor effluents and recovering said second stage liquid effluent; and f) passing said second stage vapor effluent into said first stage, said two reaction stages and said stripping stage being in a common vessel. 2. A process according to claim 1 wherein said second stage vapor effluent supplies at least a portion of said hydrogen required for said first stage reaction. 3. A process according to claim 2 wherein said first and second stages operate at a pressure of at least 850 psia. 4. A process according to claim 3 wherein said second stage is located above said first stage and said second stage vapor is passed directly from said second stage, down into said first stage. 5. A process according to claim 4 wherein said stripping stage is located below said first reaction stage. 6. A process according to claim 5 wherein said second stage contains a catalyst comprising a noble metal catalytic component for aromatics removal. 7. A process according to claim 6 wherein said second stage also removes heteroatom compounds. 8. A process according to claim 7 wherein said first and second stages operate at a pressure of at least 950 psia. 9. A process according to claim 8 wherein said second stage vapor effluent supplies all of the hydrogen for said first stage for said heteroatom removal. 10. A method for upgrading an existing diesel hydrotreating facility comprising one or more reaction vessels, strippers and associated equipment and which produces a hydroprocessed diesel fraction, said method comprising: a) reacting said hydroprocessed diesel fraction feed and hydrogen in a first reaction stage operated in a cocurrent manner under first catalytic conversion conditions in the presence of a first catalyst selective for removal of heteroatom compounds, to produce a first stage effluent comprising (i) a liquid effluent containing a diesel fraction reduced in heteroatom compounds and (ii) a vapor effluent containing vaporous heteroatom species produced by the reaction; b) passing said first stage effluent to a stripping stage wherein it is contacted with a stripping gas to form a stripped first stage liquid effluent and a stripping stage vapor effluent comprised of the first reaction stage vapor and said stripping gas; c) removing said stripping stage vapor effluent; d) passing said stripped liquid into a second reaction stage operated in a cocurrent manner, in which it reacts with hydrogen under second stage catalytic conversion conditions, in the presence of a second catalyst selective for aromatics removal, to remove aromatic compounds and produce second stage liquid and vapor effluents, wherein said vapor effluent contains unreacted hydrogen and said liquid effluent contains a diesel boiling-range hydrocarbon fraction having a heteroatom and aromatics content lower than that of said hydroprocessed diesel fraction fed into the first