초록 ▼

The invention relates to a method for the production of a coating and excipient agent for oral or dermal dosage forms, consisting of (a) 35-98% by weight of a copolymer consisting of radically polymerized C1-C4 esters of acrylic or methacrylic acid and additional (meth)acrylate monomers having funct

The invention relates to a method for the production of a coating and excipient agent for oral or dermal dosage forms, consisting of (a) 35-98% by weight of a copolymer consisting of radically polymerized C1-C4 esters of acrylic or methacrylic acid and additional (meth)acrylate monomers having functional tertiary ammonium groups and (b) 1-50% by weight of a softener and 1-15% by weight of an emulgator with an HLB value of less than 14, wherein constituents (a), (b) and (c) are mixed with or without adding water and optionally adding a pharmaceutical active substance and other conventional additives and the coating and excipient agent is produced by melting, casting, spreading or spraying. The invention is characterized in that the copolymer (a) is applied in powder form with a mean particle size of 1-40 μm.

대표청구항 ▼

The invention relates to a method for the production of a coating and excipient agent for oral or dermal dosage forms, consisting of (a) 35-98% by weight of a copolymer consisting of radically polymerized C1-C4 esters of acrylic or methacrylic acid and additional (meth)acrylate monomers having funct

The invention relates to a method for the production of a coating and excipient agent for oral or dermal dosage forms, consisting of (a) 35-98% by weight of a copolymer consisting of radically polymerized C1-C4 esters of acrylic or methacrylic acid and additional (meth)acrylate monomers having functional tertiary ammonium groups and (b) 1-50% by weight of a softener and 1-15% by weight of an emulgator with an HLB value of less than 14, wherein constituents (a), (b) and (c) are mixed with or without adding water and optionally adding a pharmaceutical active substance and other conventional additives and the coating and excipient agent is produced by melting, casting, spreading or spraying. The invention is characterized in that the copolymer (a) is applied in powder form with a mean particle size of 1-40 μm. 49/398; US-5068523, 19911100, Chandraratna, 514/543; US-5089509, 19920200, Chandraratna, 514/337; US-5130335, 19920700, Chandraratna, 514/510; US-5134159, 19920700, Chandraratna, 514/456; US-5162546, 19921100, Chandraratna, 549/023; US-5175185, 19921200, Chandraratna, 514/445; US-5183827, 19930200, Chandraratna, 514/444; US-5202471, 19930400, Chandraratna, 562/473; US-5231113, 19930700, Chandraratna, 514/510; US-5234926, 19930800, Chandraratna, 514/253; US-5248777, 19930900, Chandraratna, 546/165; US-5264456, 19931100, Chandraratna, 514/461; US-5264578, 19931100, Chandraratna, 546/269; US-5272156, 19931200, Chandraratna, 514/314; US-5278318, 19940100, Chandraratna, 549/023