초록 ▼

The present invention relates to a process for the reaction of at least one organic compound with one oxygen-delivering substance, for example a hydroperoxide, in the presence of at least one catalyst containing a metal-organic framework material comprising pores and a metal ion and an at least bide

The present invention relates to a process for the reaction of at least one organic compound with one oxygen-delivering substance, for example a hydroperoxide, in the presence of at least one catalyst containing a metal-organic framework material comprising pores and a metal ion and an at least bidentate organic compound, said bidentate organic compound being coordinately bound to the metal ion. Further, the present invention is directed to the products being obtainable by the process according to the invention.

대표청구항 ▼

The present invention relates to a process for the reaction of at least one organic compound with one oxygen-delivering substance, for example a hydroperoxide, in the presence of at least one catalyst containing a metal-organic framework material comprising pores and a metal ion and an at least bide

The present invention relates to a process for the reaction of at least one organic compound with one oxygen-delivering substance, for example a hydroperoxide, in the presence of at least one catalyst containing a metal-organic framework material comprising pores and a metal ion and an at least bidentate organic compound, said bidentate organic compound being coordinately bound to the metal ion. Further, the present invention is directed to the products being obtainable by the process according to the invention. and R2is aryl which cannot be substituted with OH or a phenolic ester group and must be substituted with a heterocyclo group at the 4-position which is a fully saturated or unsaturated ring of five or six atoms containing one or two oxygen and/or sulfur atoms and/or one to four nitrogen atoms provided that the total number of hetero atoms in the ring is four or less, or the heterocyclic group is a bicyclic ring wherein the five or six-membered ring containing oxygen and/or sulfur and/or nitrogen atoms as defined above is fused to a benzene ring; with the proviso that (1) the heterocyclo group substituted on the R2aryl is exclusive of where X1is --CRaRb-- and Y1is O, S or --NRc-- where Ra,Rb,and Rc,which may be the same or different, are independently H or C1-4alkyl; (2) R1is exclusive of aminoalkyl; (3) where R1is cycloalkyl or (cycloalkyl)alkyl, the cycloalkyl group is unsubstituted or is substituted with alkyl or hydroxy, where the alkyl is unsubstituted or is substituted with halo, alkoxy, aryl, cycloalkyl, hydroxy, nitro, cyano, thiol or alkylthio; and (4) where R1is aryl, then the heterocyclic group substituted on the R2aryl is exclusive of where Rdis H or alkyl. 2. A compound of the formula wherein the above oxadiazolyl ring is optionally substituted with alkyl, aryl, alkylthio, alkoxy, halo, nitro, keto, cyano, hydroxy, azo, oxo, thiazo, amino, substituted amino, carboxylic acid, carboxylic ester, or alkoxy further substituted with a carboxylic acid or a five- to eight-membered ring optionally containing 1 to 4 heteroatoms selected from oxygen, nitrogen and sulfur, optionally substituted by alkyl or halogen; and R1is (cycloalkyl)alkyl, or a pharmaceutically acceptable salt thereof; with the proviso that in the R1(cycloalkyl)alkyl, the cycloalkyl group is unsubstituted or is substituted with alkyl or hydroxy, where the alkyl is unsubstituted or is substituted with halo, alkoxy, aryl, cycloalkyl, hydroxy, nitro, cyano, thiol or alkylthio. 3. A compound which is: N-(3,3-dimethylbutyl)-4-(1H-indol-1-yl)benzamide; 4-(3-butyl-1,2,4-oxadiazol-5-yl)-N-(3, 3-dimethylbutyl)-benzamide; N-(3,3-dimethylcyclopentyl)-4-(1H-indol-1-yl)benzamide; or a pharmaceutically acceptable salt thereof. 4. The compound as defined in claim 2 wherein the substituent attached to the ozadiazolyl ring is alkyl. 5. The compound as defined in claim 2 wherein R1is 6. The compound as defined in claim 2 having the structure