Method and apparatus combining diagnostic ultrasound with therapeutic ultrasound to enhance thrombolysis
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-008/06
A61N-007/00
출원번호
US-0500708
(2000-02-09)
발명자
/ 주소
Moehring, Mark A.
Voie, Arne H.
Spencer, Merrill P.
출원인 / 주소
Spentech, Inc.
대리인 / 주소
Dorsey & Whitney LLP
인용정보
피인용 횟수 :
103인용 특허 :
9
초록▼
A method and apparatus for combining therapeutic pulsed or continuous-wave ultrasound with diagnostic pulsed ultrasound are described. In both a therapeutic mode and in a diagnostic mode, the ultrasound is administered from a single probe to a patient suffering from thrombosis. The ultrasound can ha
A method and apparatus for combining therapeutic pulsed or continuous-wave ultrasound with diagnostic pulsed ultrasound are described. In both a therapeutic mode and in a diagnostic mode, the ultrasound is administered from a single probe to a patient suffering from thrombosis. The ultrasound can have the same or different frequency ranges in the diagnostic and therapeutic modes. The pulsed or continuous-wave ultrasound in the therapeutic mode enhances a lysing effect of a thrombolytic agent. The pulsed ultrasound in the diagnostic mode allows monitoring of blood flow to locate a thrombus, to determine an optimal window to administer the therapeutic pulsed ultrasound, and to detect when recanalization has occurred. If an operator attends the device, a graphical display operates during the diagnostic mode to display an image representative of the blood flow.
대표청구항▼
A method and apparatus for combining therapeutic pulsed or continuous-wave ultrasound with diagnostic pulsed ultrasound are described. In both a therapeutic mode and in a diagnostic mode, the ultrasound is administered from a single probe to a patient suffering from thrombosis. The ultrasound can ha
A method and apparatus for combining therapeutic pulsed or continuous-wave ultrasound with diagnostic pulsed ultrasound are described. In both a therapeutic mode and in a diagnostic mode, the ultrasound is administered from a single probe to a patient suffering from thrombosis. The ultrasound can have the same or different frequency ranges in the diagnostic and therapeutic modes. The pulsed or continuous-wave ultrasound in the therapeutic mode enhances a lysing effect of a thrombolytic agent. The pulsed ultrasound in the diagnostic mode allows monitoring of blood flow to locate a thrombus, to determine an optimal window to administer the therapeutic pulsed ultrasound, and to detect when recanalization has occurred. If an operator attends the device, a graphical display operates during the diagnostic mode to display an image representative of the blood flow. emits white light; a second light source that emits a specific wavelength light; a light source switcher that selectively introduces one of said white light and said specific wavelength light into said optical light guide along a light path; a rotary color-filter/shutter; and a filter/shutter driver that moves said color-filter/shutter in a direction substantially transverse to the light path between a first operative position and a second operative position. 2. An electronic endoscope system as set forth in claim 1, wherein said light source switcher includes: a light deflector; and a deflector driver that moves said light deflector between a first operative position and a second operative position, the white light, emitted from said first light source, being directly introduced into said optical light guide when said light deflector is positioned at said first operative position, the white light, emitted from said first light source, being blocked off by said light deflector and the specific wavelength light, emitted from said second light source, being introduced by said light deflector into said optical light guide when said light deflector is positioned at said second operative position. 3. An electronic endoscope system as set forth in claim 2, wherein said light source switcher further includes: an illumination mode selection system that selects one of a first illumination mode, in which said white light is introduced into said optical light guide, and a second illumination mode, in which said specific wavelength light is introduced into said optical light guide; and a controller that controls said deflector driver such that said light deflector is positioned at said first operative position when said first illumination mode is selected by said illumination mode selection system, and such that said light deflector is positioned at said second operative position when said second illumination mode is selected by said illumination mode selection system. 4. An electronic endoscope system as set forth in claim 1, wherein said color-filter/shutter functions as a rotary color filter when moved to said first operative position by said filter/shutter driver and said color-filter/shutter functions as a rotary shutter when moved to said second operative position by said filter/shutter driver, said white light being converted into three primary color lights through said color-filter/shutter, positioned at said first operative position, whereby said three primary color lights are cyclically and sequentially introduced into said optical light guide, said specific wavelength light being cyclically and sequentially introduced into said optical light guide through said color-filter/shutter positioned at said second operative position. 5. An electronic endoscope system as set forth in claim 4, wherein said light source device further includes: an illumination mode selection system that selects one of a first illumination mode, in which said white light is introduced into said optical light guide, and a second illumination mode, in which said specific wavelength light is introduced into said optical light guide; and a controller that controls said filter/shutter driver such that said color-filter/shutter is positioned at said first operative position when said first illumination mode is selected by said illumination mode selection system, and such that said color-filter/shutter is positioned at said second operative position when said second illumination mode is selected by said illumination mode selection system. 6. An electronic endoscope system as set forth in claim 4, wherein said rotary color-filter/shutter comprises a disk element having three primary color filters circumferentially spaced from each other at regular angular intervals, areas between adjacent color filters being formed as light-shielding areas, said light-shielding areas extending radially outwardly beyond said color filters such that the exte nded areas form said rotary shutter. 7. An electronic endoscope system as set forth in claim 4, wherein said rotary color-filter/shutter comprises a disk element having three primary color filters circumferentially spaced from each other at regular angular intervals, areas between adjacent color filters being formed as light-shielding areas, one of said light-shielding areas extending radially outwardly beyond said color filters such that the extended area forms said rotary shutter. 8. A rotary color-filter/shutter comprising: a disk element having three primary color filters circumferentially spaced from each other at regular angular intervals, areas between adjacent color filters being formed as light-shielding areas, at least one of said light-shielding areas extending radially outwardly beyond said color filters such that the extended area for ms a rotary shutter. 9. An electronic endoscope system comprising: a scope having an image sensor provided at a distal end thereof to generate image-pixel signals; an image-signal processing unit, to which a proximal end of said scope is connected, that processes the image-pixel signals to thereby produce a video signal; a light source device provided in said image-signal processing unit; and an optical light guide that extends through said scope, said optical light guide being optically connected to said light source when the connection is established between said scope and said image-signal processing unit, wherein said light source device comprises: a first light source that emits white light; a second light source that emits a specific wavelength light; a light source switcher that selectively introduces one of said white light and said specific wavelength light into said optical light guide; a rotary shutter associated with said second light source such that said rotary shutter is interposed in a specific-wavelength-light path through which said specific wavelength light passes, said rotary shutter including at least two light-shielding elements circumferentially spaced from each other at regular angular intervals and having different radial lengths; and a shutter driver that relatively moves and positions said rotary shutter with respect to said specific-wavelength-light path such that said specific-wavelength-light path is selectively blocked off by said light-shielding elements having the different radial lengths, whereby an exposure time, during which said image sensor is illuminated with said specific wavelength light, is varied. 10. An electronic endoscope system as set forth in claim 9, wherein said light source device further comprises a rotary color filter interposed in a white-light path through which said white light passes, a rotational frequency of said color filter being an integral multiple of a rotational frequency of said rotary shutter. 11. An electronic endoscope system as set forth in claim 9, wherein said light source switcher includes: a light deflector; and a deflector driver that moves said light deflector between a first operative position and a second operative position, the white light, emitted from said first light source, being directly introduced into said optical light guide when said light deflector is positioned at said first operative position, the white light, emitted from said first light source, being blocked off by said light deflector and the specific wavelength light, emitted from said second light source, being introduced-by said light deflector into said optical light guide when said light deflector is positioned at said second operative position. 12. An electronic endoscope system as set forth in claim 11, wherein said light source switcher further includes: an illumination mode selection system that selects one of a first illumination mode, in which said white light is introduced into said optical light guide, and a second illumination mode, in which said specific wavelength light is introduced into said optica l light guide; and a controller that controls said deflector driver such that said light deflector is positioned at said first operative position when said first illumination mode is selected by said illumination mode selection system, and such that said light deflector is positioned at said second operative position when said second illumination mode is selected by said illumination mode selection system. 13. An electronic endoscope system as set forth in claim 9, wherein said rotary shutter is moved by said shutter driver between first and second relative positions with respect to said specific-wavelength-light path, said specific-wavelength-light path being blocked off by a longer one of said light-shielding elements when said rotary shutter is positioned at said first relative position, said specific-wavelength-light path being blocked off by both of said light-shielding elements when said rotary shutter is positioned at said second relative position. 14. An electronic endoscope system as set forth in claim 13, wherein said light source device further includes: an exposure mode selection system that selects one of a first exposure mode, in which said specific-wavelength-light path is blocked off by the longer one of said light-shielding elements, and a second exposure mode, in which said specific-wavelength-light path is blocked off by both of said light-shielding elements; and a controller that controls said shutter driver such that said rotary shutter is positioned at said first relative position when said first exposure mode is selected by said exposure mode selection system, and such that said rotary shutter is positioned at said second relative position when said second exposure mode is selected by said exposure mode selection system.
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