IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
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출원번호 |
US-0829512
(1997-03-28)
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우선권정보 |
CH-199600806 (1996-03-28) |
발명자
/ 주소 |
- Roduit, Jean-Paul
- Kalbermatten, Georges
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
0 인용 특허 :
15 |
초록
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A process for the preparation of arylamides of heteroaromatic carboxylic acids of the formula: in which each Anis nitrogen or CRn(n=1 to 5), with the proviso that at least one of the ring members is nitrogen and that two nitrogen atoms are not bonded directly to one another; R1to R5,if present, ind
A process for the preparation of arylamides of heteroaromatic carboxylic acids of the formula: in which each Anis nitrogen or CRn(n=1 to 5), with the proviso that at least one of the ring members is nitrogen and that two nitrogen atoms are not bonded directly to one another; R1to R5,if present, independently of one another; C1-4-alkyl or aryl, one of the substituents R1to R5being a group of the formula --OR, in which R is an optionally substituted aromatic or heteroaromatic radical; R6is hydrogen or C1-4-alkyl; and R7is an optionally substituted aromatic or heteroaromatic radical. The amides are obtained from the corresponding heteroaromatic halogen compounds, the corresponding aromatic amines and carbon monoxide in the presence of palladium diphosphine complex. Compounds of this class (Formula I) are important herbicides.
대표청구항
▼
1. A process for the preparation of an amide of formula: wherein: A1is nitrogen or CR1, A2is nitrogen or CR2, A3is nitrogen or CR3, A4is nitrogen or CR4,and A5is nitrogen or CR5, with the proviso that at least one of the ring members is A1to A5is nitrogen and that two nitrogen atoms are no
1. A process for the preparation of an amide of formula: wherein: A1is nitrogen or CR1, A2is nitrogen or CR2, A3is nitrogen or CR3, A4is nitrogen or CR4,and A5is nitrogen or CR5, with the proviso that at least one of the ring members is A1to A5is nitrogen and that two nitrogen atoms are not bonded directly to one another; R1to R5,if present, independently of one another are each a member of the group consisting of hydrogen, C1-4-alkyl or aryl, also one of the substituents R1to R5being a group of the formula --OR, in which R is an aromatic radical, a heteroaromatic radical, an aromatic radical substituted with at least one lower alkyl, halogenated alkyl, lower alkoxy, lower alkylthio or alkanesulfonyl, or (p-) fluorophenyl, or a heteroaromatic radical substituted with at least one lower alkyl, halogenated alkyl, lower alkoxy, lower alkylthio or alkanesulfonyl; R6is hydrogen or C1-4-alkyl; and R7is an aromatic radical, a heteroaromatic radical, an aromatic radical substituted with at least one lower alkyl, halogenated alkyl, lower alkoxy, lower alkylthio or alkanesulfonyl, or (p-) fluorophenyl, or a heteroaromatic radical substituted with at least one lower alkyl, halogenated alkyl, lower alkoxy, lower alkylthio or alkanesulfonyl. in a first step, reacting a dihalide of the formula: wherein A1to A5are as defined above, with the proviso that one of the radicals R1to R5on a carbon atom adjacent to a ring nitrogen atom is replaced with Z, Z is chlorine, bromine or iodine, and X independently thereof is chlorine, bromine or iodine, with an aromatic or heteroaromatic hydroxyl compound of formula: R--OH VI, wherein R is as defined above, to give a (hetero)aryloxy halogen compound of formula: wherein A1to A5,and X are as defined above, and, in a second step, said product is reacted with carbon monoxide and an amine of formula: R6--NH--R7 III wherein R6and R7are as defined above, in the presence of a complex of palladium with a diphosphine of formula: R8R9P--[CH2]n--PR10R11 IV
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