Method and apparatus for flow-through hybridization
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C12M-001/34
C12Q-001/68
C12P-019/34
C07H-021/02
C07H-021/04
출원번호
US-0204865
(1998-12-03)
발명자
/ 주소
Chen, Jer-Kang
Chiesa, Claudia
Fry, George A.
Furniss, Vergine C.
Lambert, Stephen M.
O'Neill, Roger
Mehrpouyan, Majid
출원인 / 주소
PE Corporation (NY)
대리인 / 주소
Pennie & Edmonds LLP
인용정보
피인용 횟수 :
8인용 특허 :
14
초록▼
The present invention provides substrates and apparatuses for efficient, rapid and specific capture, and optimal recovery, of nucleic acids, as well as methods of their use. The substrate is porous in nature and has a capture polynucleotide capable of hybridizing to a target nucleic acid immobilized
The present invention provides substrates and apparatuses for efficient, rapid and specific capture, and optimal recovery, of nucleic acids, as well as methods of their use. The substrate is porous in nature and has a capture polynucleotide capable of hybridizing to a target nucleic acid immobilized thereon. Upon flowing a sample containing or suspected of containing the target nucleic acid through the porous substrate, the target nucleic acid is rapidly captured. Following capture, the target nucleic acid can be efficiently recovered for subsequent use.
대표청구항▼
The present invention provides substrates and apparatuses for efficient, rapid and specific capture, and optimal recovery, of nucleic acids, as well as methods of their use. The substrate is porous in nature and has a capture polynucleotide capable of hybridizing to a target nucleic acid immobilized
The present invention provides substrates and apparatuses for efficient, rapid and specific capture, and optimal recovery, of nucleic acids, as well as methods of their use. The substrate is porous in nature and has a capture polynucleotide capable of hybridizing to a target nucleic acid immobilized thereon. Upon flowing a sample containing or suspected of containing the target nucleic acid through the porous substrate, the target nucleic acid is rapidly captured. Following capture, the target nucleic acid can be efficiently recovered for subsequent use. 00, af Strom, 428/195; US-5098772, 19920300, af Strom; US-5104719, 19920400, Kamen et al.; US-5139917, 19920800, Hare; US-5163247, 19921100, Weber et al.; US-5236801, 19930800, Hare; US-5242739, 19930900, Kronzer et al.; US-5242781, 19930900, Ohbayashi et al.; US-5271990, 19931200, Kronzer et al.; US-5366837, 19941100, Sakai; US-5370132, 19941200, Weber et al.; US-5387107, 19950200, Gunter et al.; US-5407729, 19950400, Verden et al., 428/196; US-5419944, 19950500, Sammis; US-5424141, 19950600, Croner, 428/200; US-5441056, 19950800, Weber et al.; US-5480506, 19960100, Mahn, Sr. et al.; US-5501902, 19960300, Kronzer, 428/323; US-5514435, 19960500, Suzuki et al.; US-5603996, 19970200, Overcash et al.; US-5612168, 19970300, Ishikawa; US-5620548, 19970400, Hare, 156/240; US-5665476, 19970900, Oez; US-5678247, 19971000, Vickers; US-5741387, 19980400, Coleman; US-5759738, 19980600, Tsuno et al.; US-5798179, 19980800, Kronzer, 428/411.1; US-5816730, 19981000, Alspaw et al.; US-5882388, 19990300, Adair et al.; US-5925712, 19990700, Kronzer; US-5932352, 19990800, Higgins; US-5948586, 19990900, Hare; US-6033824, 20000300, Hare et al.; US-6087061, 20000700, Hare et al., 430/138; US-6096475, 20000800, Hare et al., 430/138; US-6228543, 20010500, Mizuno et al.; US-6241841, 20010600, Mahn, Sr. et al.; US-6383710, 20020500, Hare et al.; US-6423466, 20020700, Hare et al.
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이 특허에 인용된 특허 (14)
Tom Henry K. (La Honda CA) Rowley Gerald L. (Cupertino CA), Concentrating zone method in heterogeneous immunoassays.
Koontz Steven L. (Seabrook TX) Spaulding Glenn F. (Houston TX), Method of making a membrane having hydrophilic and hydrophobic surfaces for adhering cells or antibodies by using atomic.
Van Ness Jeffrey (Bothell WA) Petrie Charles R. (Woodinville WA) Tabone John C. (Bothell WA) Vermeulen Nicolaas M.J. (Woodinville WA) Reed Michael W. (Seattle WA), Solid supports for nucleic acid hybridization assays.
Lee, Linda G.; Woo, Sam L.; Ma, Congcong; Reel, Richard T.; Oldham, Mark F.; Cox, David M.; Schroeder, Benjamin G.; Sorenson, Jon M.; Wiyatno, Willy, Apparatus, system, and method using immiscible-fluid-discrete-volumes.
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