초록 ▼

Polyphenol-containing compositions, for example cocoa procyanidin monomer and/or oligomer-containing compositions, and their use inhibiting bacterial growth are disclosed. Compositions may be used for human and veterinary animal administration and may be, for example, in a form of a food, a dietary

Polyphenol-containing compositions, for example cocoa procyanidin monomer and/or oligomer-containing compositions, and their use inhibiting bacterial growth are disclosed. Compositions may be used for human and veterinary animal administration and may be, for example, in a form of a food, a dietary supplement, or a pharmaceutical.

대표청구항 ▼

1. A method of inhibiting bacterial growth in a mammal suffering from, or at risk of, a bacterial infection comprising administering to the mammal a composition comprising an effective amount of a polymeric compound of the formula An,wherein A is a monomer of the following formula: wherein n is

1. A method of inhibiting bacterial growth in a mammal suffering from, or at risk of, a bacterial infection comprising administering to the mammal a composition comprising an effective amount of a polymeric compound of the formula An,wherein A is a monomer of the following formula: wherein n is an integer from 2-18, such that there is at least one terminal monomeric unit A, and one or a plurality of additional monomeric units; R is 3-(α) --OH, 3-(β) --OH, 3-(α)-O-sugar, or 3-(β)-O-sugar; bonding between adjacent monomers takes place at positions selected from the group consisting of 4, 6, and 8; a bond for additional monomeric unit in position 4 has alpha or beta stereochemistry; X, Y, and Z are selected from the group consisting of monomeric unit A, hydrogen, and a sugar, with the provisos that as to at least one terminal monomeric unit, bonding of the additional monomeric unit thereto is at position 4 and optionally Y=Z=hydrogen; the sugar is optionally substituted with a phenolic moiety, and pharmaceutically acceptable salts, oxidation products thereof, or combinations thereof. 2. The method of claim 1, wherein the mammal suffers from a bacterial infection. 3. The method of claim 2, wherein the mammal is a human. 4. The method of claim 2, wherein the mammal is a veterinary animal. 5. The method of claim 1, wherein the polymeric compound is in the form of a cocoa extract. 6. The method of claim 1, wherein the polymeric compound is in the form of a cocoa extract fraction. 7. The method of claim 6, wherein the fraction further comprises epicatechin. 8. The method of claim 1, wherein n is 2. 9. The method of claim 6, wherein the polymeric compound is a procyanidin B2 or B5 dimer. 10. The method of claim 1, wherein n is 3-12. 11. The method of claim 1, wherein the composition further comprises a pharmaceutically acceptable carrier. 12. The method of claim 1, wherein the composition is a food. 13. The method of claim 1, wherein the composition is a dietary supplement. 14. The method of claim 1, wherein the mammal suffers from a Helicobacter pylori infection. 15. The method of claim 1, wherein the mammal suffers from an urinary tract infection.