초록 ▼

A method and system for assessing whether adjustment factors used in a process for testing or monitoring an operational system need to be updated or changed, as well as changing and updating these adjustment factors if needed or desired. At least one current adjustment factor is selected, along with

A method and system for assessing whether adjustment factors used in a process for testing or monitoring an operational system need to be updated or changed, as well as changing and updating these adjustment factors if needed or desired. At least one current adjustment factor is selected, along with the relevant data. The relevant data is then analyzed to generate results that are collected so that a determination can be made as to whether the current adjustment factor(s) needs to be changed. If it is determined that the current adjustment factor(s) needs to be changed, an updated adjustment factor(s) is provided to replace it. Preferably, the updated adjustment factor(s) is validated before incorporating it into the testing or monitoring process.

대표청구항 ▼

A method and system for assessing whether adjustment factors used in a process for testing or monitoring an operational system need to be updated or changed, as well as changing and updating these adjustment factors if needed or desired. At least one current adjustment factor is selected, along with

A method and system for assessing whether adjustment factors used in a process for testing or monitoring an operational system need to be updated or changed, as well as changing and updating these adjustment factors if needed or desired. At least one current adjustment factor is selected, along with the relevant data. The relevant data is then analyzed to generate results that are collected so that a determination can be made as to whether the current adjustment factor(s) needs to be changed. If it is determined that the current adjustment factor(s) needs to be changed, an updated adjustment factor(s) is provided to replace it. Preferably, the updated adjustment factor(s) is validated before incorporating it into the testing or monitoring process. Research Communications (1978) 81(1):154-60. Groves, J.T., et al., "Hydroxylation by Cytochrome P-450 and Metalloporphyrin Models. Evidence for Allylic Rearrangement," J. Am. Chem. Soc., (1984) 106: 2177-81. Guengerich, F. P., et al., "Role of Human Cytochrome P-450 IIE1 in the Oxidation of Many Low Molecular Weight Cancer Suspects," Chem. Res. Toxicol., (1991) 4:168-79. Guengerich, F. P., et al., "Evidence for a 1-Electron Oxidation Mechanism in N-Dealkylation of N,N-Dialkylanilines by Cytochrome P450 2B1," J. Biol. Chem., 271(44):27321-9 (Nov. 1996). Hammond, G. S., "A Correlation of Reaction Rates," J. Am. Chem. Soc., (1955) 77(2):334-40. Hanzlik, R.P., et al., "Intramolecular Kinetic Deuterium Isotope Effects on Microsomal Hydroxylation and Chemical Chlorination of Toluene-α-d1and Toluene-α,α-d2,"J. Am. Chem. Soc., (1985) 107:7164-7. Harada, N., et al., "Kinetic Isotope Effects on Cytochrome P-450-Catalyzed Oxidation Reaction," J. Biol. Chem., (1984) 259(5):3005-10. Hasemann, C.A., et al.,