초록 ▼

A modified silica support having a polar phase bound to its surface and suitable for use for chromatographic separations, having the following formula: wherein, m=0-20; n=0-20; p=1-50; X is sulfonyl, carbonyl, carbamoyl, or oxycarbonyl; R1=H, alkyl, substituted alkyl, aryl or substituted aryl group

A modified silica support having a polar phase bound to its surface and suitable for use for chromatographic separations, having the following formula: wherein, m=0-20; n=0-20; p=1-50; X is sulfonyl, carbonyl, carbamoyl, or oxycarbonyl; R1=H, alkyl, substituted alkyl, aryl or substituted aryl groups; R2=alkyl, substituted alkyl, aryl or substituted aryl groups; and R3and R4are alkyl, aryl, hydroxyl, or alkoxyl groups or groups including oxygen atoms cross-linked to silicon atoms. Also, a polar silane intermediate to make this support.

대표청구항 ▼

1. A modified silica Support having a a polar phase bound to its surface and suitable for use for chromatographic separations, said modified silica support having the following formula: wherein, m=0-20; n=0-20; p=1-50; X is sulfonyl, carbonyl, carbamoyl or oxycarbonyl; R1=H, alkyl, substitute

1. A modified silica Support having a a polar phase bound to its surface and suitable for use for chromatographic separations, said modified silica support having the following formula: wherein, m=0-20; n=0-20; p=1-50; X is sulfonyl, carbonyl, carbamoyl or oxycarbonyl; R1=H, alkyl, substituted alkyl, aryl or substituted aryl groups; R2=alkyl, substituted alkyl, aryl, or substituted aryl groups; and R3and R4are alkyl, aryl, hydroxyl, or alkoxyl groups, or groups including oxygen atoms cross-linked to silicon atoms. 2. The modified silica support of claim 1 in which R1or R2are C1 to C30 alkyl group. 3. The modified silica support of claim 1 in which R1or R2are carbon chains of sufficient length to impart an ion; exchange, ligand exchange, hydrophilic or reverse phase property to the modified silica support. 4. The modified silica support of claim 1 in which X is sulfonyl. 5. The modified silica a support of claim 1 in which p is at least 1. 6. The modified silica support of claim 1 in which at least some of the hydroxyl groups on the silica surface are end-capped by non-polar and/or polar groups.