Topical compositions containing extracellular products of Pseudomonas lindbergii and Emu oil
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-039/108
A61K-039/07
A61K-006/00
A61K-035/00
A01N-025/34
출원번호
US-0383975
(1999-08-26)
발명자
/ 주소
Farmer, Sean
출원인 / 주소
Ganeden Biotech, Inc.
대리인 / 주소
Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
인용정보
피인용 횟수 :
43인용 특허 :
14
초록▼
The present invention discloses compositions derived from an isolated Bacillus species, spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain, suitable for topical application to the skin or mucosal membranes of
The present invention discloses compositions derived from an isolated Bacillus species, spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain, suitable for topical application to the skin or mucosal membranes of a mammal, which are utilized to inhibit the growth of bacterium, yeast, fungi, virus, and combinations thereof. The present invention also discloses methods of treatment and therapeutic systems for inhibiting the growth of bacterium, yeast, fungi, virus, and combinations thereof, by topical application of therapeutic compositions which are comprised, in part, of isolated Bacillus species, spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain. In addition, the present invention also discloses compositions, methods of treatment, and therapeutic systems for inhibiting the growth of bacterium, yeast, fungi, virus, and combinations thereof, comprising an extracellular product of Pseudomonas lindbergii comprising a supernatant or filtrate of a culture of said Pseudomonas lindbergii strain.
대표청구항▼
1. A composition comprising an extracellular product of Pseudomonas lindbergii, Emu oil, and an anti-ftngal agent selected from the group consisting of Amphotericin B, Carbol-Fuchsin, Ciclopirox, Clotrimzole, Econazole, Haloprogin, Ketoconazole, Mafenide, Miconazole, Naftifine, Nystatin, Oxiconazole
1. A composition comprising an extracellular product of Pseudomonas lindbergii, Emu oil, and an anti-ftngal agent selected from the group consisting of Amphotericin B, Carbol-Fuchsin, Ciclopirox, Clotrimzole, Econazole, Haloprogin, Ketoconazole, Mafenide, Miconazole, Naftifine, Nystatin, Oxiconazole, Silver Sulfadiazine, Sulconazole, Terbinafine, Tioconazole, Tolnafiate, Undecylenic acid, wherein said composition is in the form of an emulsion, a cream, a lotion, a gel, an ointment, a suspension, an aerosol spray, or a semi-solid formulation. 2. The composition of claim 1, wherein said extracellular product is a supernatant or filtrate of a culture of a Pseudomonas lindbergii strain. 3. The composition of claim 1, wherein said composition comprises approximately 0.5% to approximately 99.9% of said Emu oil, by weight. 4. The composition of claim 1, wherein said composition further comprises a carrier, wherein said carrier is selected from the group consisting of trehalose, malto-dextrin, rice flour, micro-crystalline cellulose, magnesium sterate, inositol, fructo-oligosaccharide, gluco-oligosaccharide, dextrose, sucrose, talc, water, physiological salt solution, urea, methanol, ethanol, propanol, butanol, ethylene glycol, propylene glycol, white pertrolatum, isopropyl myristate, lanolin, lanolin alcohol, mineral oil, lavender oil, nasturtium extract oil, sorbitan mono-oleate, cetylstearyl alcohol, hydroxypropyl cellulose, detergent, sucrose stearate, sucrose cocoate, sucrose distearate, 2-ethyl-1,3-hexanediol, polyoxypropylene-15-stearyl ether, glycerol stearate, glycerin, synthetic spermaceti, cetyl alcohol, butylparaben, propylparaben and methylparaben. 5. The composition of claim 1, wherein said extracellular product is a culture supernatant fractionated using a method selected from the group consisting of filtration, liquid chromatography, ion exchange chromatography, and High Performance Liquid Chromatography (HPLC). 6. The composition of claim 1, wherein said extracellular product is in the form of a liquid. 7. The composition of claim 6, wherein said liquid extracellular product and emu oil are present in a ratio of approximately 8:2. 8. The composition of claim 1, wherein said extracellular product comprises approximately 1% of said composition. 9. The composition of claim 1, wherein said extracellular product comprises approximately 10% of said composition. 10. The composition of claim 1, wherein said extracellular product comprises approximately 75% of said composition. 11. The composition of claim 1, wherein said extracellular product comprises approximately 90% of said composition. 12. The composition of claim 1, wherein said extracellular product comprises approximately 50% of said composition. 13. The composition of claim 1, wherein said emu oil comprises between 10 to 75% of said composition. 14. The composition of claim 1, wherein said emu oil comprises between 25 to 60% of said composition. 15. The composition of claim 1, wherein said composition further comprises an emulsifier. 16. The composition of claim 1, wherein said composition is in the form of an emulsion. 17. The composition of claim 1, wherein said composition is in the form of a cream. 18. The composition of claim 1, wherein said composition is in the form of a lotion. 19. The composition of claim 1, wherein said composition is in the form of a gel. 20. The composition of claim 1, wherein said composition is in the form of an ointment. 21. The composition of claim 1, wherein said composition is in the form of an aerosol spray. 22. The composition of claim 1, wherein said composition is in the form of a semi-solid formulation. 23. The composition of claim 1, wherein said composition further comprises an extracellular product of Bacillus coagulans.
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이 특허에 인용된 특허 (14)
Ghosh Peter (Fairlight AUX) Whitehouse Michael (Millswood AUX) Dawson Michael (Newton AUX) Turner Athol G. (Forestville AUX), Anti-inflammatory composition derived from emu oil.
Vinopal Robert T. (Mansfield CT) Nelson ; Jr. John D. (Bethlehem CT) Glynn Michael W. (Darien CT) Coughlin Robert W. (Storrs CT) Vieth Robert F. (Manchester CT) Geiger Jon R. (West Hartford CT), Synergistic biocide composition containing pyrithione plus an additive.
Farmer, Sean; Lefkowitz, Andrew R., Methods for inhibiting microbial infections associated with sanitary products and for enhancing sanitary product degradation.
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