Enhancement of vascular function by modulation of endogenous nitric oxide production or activity
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A23L-001/305
A61K-009/00
A61K-031/195
출원번호
US-0060252
(2002-02-01)
발명자
/ 주소
Cooke, John P.
Dzau, Victor J.
Gibbons, Gary H.
출원인 / 주소
The Board of Trustees of the Leland Stanford Junior University
대리인 / 주소
Foley & Lardner
인용정보
피인용 횟수 :
35인용 특허 :
44
초록▼
Vascular function and structure is maintained or improved by long term administration of physiologically acceptable compounds which enhance the level of endogenous nitric oxide or other intermediates in the NO induced relaxation pathway in the host. Alternatively, or in combination, other compounds
Vascular function and structure is maintained or improved by long term administration of physiologically acceptable compounds which enhance the level of endogenous nitric oxide or other intermediates in the NO induced relaxation pathway in the host. Alternatively, or in combination, other compounds may be administered which provide for short term enhancement of nitric oxide, either directly or by physiological processes.
대표청구항▼
Vascular function and structure is maintained or improved by long term administration of physiologically acceptable compounds which enhance the level of endogenous nitric oxide or other intermediates in the NO induced relaxation pathway in the host. Alternatively, or in combination, other compounds
Vascular function and structure is maintained or improved by long term administration of physiologically acceptable compounds which enhance the level of endogenous nitric oxide or other intermediates in the NO induced relaxation pathway in the host. Alternatively, or in combination, other compounds may be administered which provide for short term enhancement of nitric oxide, either directly or by physiological processes. tep is accomplished by selecting raw unprocessed carrots. 11. The process as defined in claim 10, and the step of: prior to the leaching step, grinding the selected carrot material to a particle size below a predetermined level to produce a carrot material puree. 12. The process as defined in claim 1 wherein, said leaching step is accomplished by the steps of adding a puree of the carrot material to the aqueous solution, mixing the carrot material with the aqueous material to contact water-soluble sugars in the carrot material with the aqueous solution and removing the carrot material from the aqueous solution. 13. The process as defined in claim 12 wherein, the adding, mixing and removing steps are repeated until the sugar remaining in the carrot material is reduced to below about 1% by weight of the solids. 14. The process as defined in claim 1, and the step of: after the leaching step and before the separating step, adding an aqueous solution to the carrot material; and performing the separating step by wet-grinding the carrot material to enable a substantial majority of the carrot material to pass beyond a particle sizing device. 15. The process as defined in claim 1 wherein, said separating step is accomplished by passing a mixture of the carrot material and an aqueous solution through a separating screen preventing passage of particulate material larger than about 3 millimeters. 16. The process as defined in claim 1 wherein, the bleaching step is accomplished at an elevated temperature. 17. The process as defined in claim 16 wherein, the bleaching step is accomplished at a temperature in the range of about 120 degrees F. to about 150 degrees F. while constantly mixing the carrot material and the aqueous solution. 18. The process as defined in claim 17 wherein, the bleaching step is accomplished at a temperature in the range of about 140 degrees F. to about 145 degrees F. and the bleaching agent is benzoyl peroxide. 19. The process as defined in claim 1 wherein, the removing step is accomplished by removing the aqueous solution from the bleached carrot material until the solids content of the remaining carrot material is above a predetermined level. 20. The process as defined in claim 19 wherein, the removing step is accomplished by pressing the aqueous solution from the carrot material until the solids content of the remaining carrot material is at least above about 20%. 21. The process as defined in claim 1 wherein, the drying step is accomplished by feeding the bleached carrot material into a moving hot air stream having an air temperature in excess of 500 degrees F. 22. The process as defined in claim 21 wherein, the bleached carrot material is fed into a moving hot air stream having a temperature in the range of about 550 degrees F. to about 600 degrees F. 23. The process as defined in claim 1, and the step of: after the drying step, milling the dried carrot material to enable a substantial majority of the carrot material to pass through a particle size limiting device passing particles below a predetermined size. 24. The process as defined in claim 23 wherein, the milling step is accomplished using a turbine mill while simultaneously continuing the drying step in the turbine mill. 25. The process as defined in claim 24 wherein, the turbine mill is operated at a tip speed in excess of 20,000 feed per minute. 26. The process as defined in claim 24 and the steps of: after the separating step, adding fresh aqueous solution to the separated puree of carrot material having reduced sugar content, and repeating the mixing, separating and adding steps until the sugar content of the puree of carrot material is reduced to less than about 1 weight percent of the solids. 27. The process as defined in claim 23 wherein, the milling step is accomplished until 95% of the carrot material can pass through a sizing device passing particles having siz e of 200 microns or less. 28. The process as defined in claim 23 wherein, the milling step is accomplished until 95% of the carrot material can pass through a sizing device passing particles having a size of 100 microns or less. 29. The product produced by the process as defined in claim 1. 30. A nutritionally-fortified, fiber containing, food product comprising: a food product having between about 0.5 weight percent and about 15 weight percent of a carrot fiber produced by the process as defined in claim 1. 31. A process for producing a food grade, dietary fiber product having a water binding capacity of at least about 10 times by weight comprising the steps of: a. selecting carrot material as a source for the fiber product; b. mixing a puree of carrot material having a solids content in the range of about 8 to about 15 weight percent with an aqueous solution sufficient to reduce the solids content of the mixture to a range of about 1 to 6 weight percent in order to contact the carrot material with the aqueous solution for the removal of sugar from the carrot material; c. separating the carrot material from the aqueous solution to produce a puree of carrot material with reduced sugar content having a solids content of at least about 8%; d. adding fresh aqueous solution to the puree of carrot material with reduced sugar content until the solids content of the resulting mixture is about 4 to about 6 weight percent; e. after the adding step, wet grinding the carrot material in the aqueous solution until a substantial majority of the carrot material therein has a size of about 3 millimeters or less; f. elevating the temperature of the mixture of carrot material and aqueous solution passing through the sizing device to a temperature above about 100 degrees F. and below about 150 degrees F.; g. mixing a bleaching agent, selected from the group consisting of benzoyl peroxide, hydrogen peroxide and peracitic acid, with the mixture of carrot material and aqueous solution at the elevated temperature until the carrot material is bleached to a creamy color; h. removing the aqueous solution from the bleached carrot material until the solids content of the bleached carrot material is at least about 20%; i. drying the bleached carrot material after removing the aqueous solution; j. milling the dried carrot material until a 95% of the milled carrot material has a size of less than 200 microns; and k. passing the milled, dried, carrot material through a sizing device to produce a food grade dietary fiber product of known maximum particle size and a water bending capacity of at least 10 times by weight. 32. The process as defined in claim 31 wherein, the carrot material puree is obtained from a fresh carrot cutting and peeling process. 33. The process as defined in claim 32 wherein, the mixing step is accomplished by mixing a puree of carrot material having a solids content of about 10 to about 12 weight percent with an aqueous solution sufficient to reduce the solids content of the mixture to about 1 to about 6 weight percent. 34. The process as defined in claim 33 wherein, the separating step produces a puree of carrot material having a solids content of about 10 to about 12 weight percent. 35. The process as defined in claim 34 wherein, the adding step is accomplished by adding fresh aqueous solution until the solids content is about 5 to about 6 weight percent. 36. The process as defined in claim 35 wherein, the elevating step is accomplished by elevating the temperature of the mixture of carrot material and aqueous solution to about 140 to about 150 degrees F., and the step of mixing a bleaching agent is accomplished by mixing benzoyl peroxide with the mixture while at the elevated temperature in the amount of at least 0.07% by weight of the mixture of carrot material and aqueous solution. 37. The process as defined in claim 34 wherein, the step of mixing a bleaching agent is continu
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (44)
Inoue Ranko (Tokyo JPX) Yamamoto Kohzo (Tokyo JPX), Active amino acid Ca, beverages containing same, and process for their production.
Garvey David S. ; Letts L. Gordon ; Renfroe H. Burt ; Tam Sang William, Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs.
Walaszek Zbigniew (Bastrop TX) Slaga Thomas J. (Austin TX) Hanausek Margaret (Bastrop TX), Formula and method for the prevention and treatment of hypercholesterolemia and cellular hyperproliferative disorders.
Murad Ferid (Lake Forest IL) Kerwin James F. (Grayslake IL) Gorsky Lee D. (Highland Park IL), Guanidino compounds as regulators of nitric oxide synthase.
Acosta Phyllis J. B. (Westerville OH) Grondalski Richard A. (Columbus OH) Liebrecht Jeffrey W. (Columbus OH) Reynolds Patricia A. (Columbus OH), Medical foods for the nutritional support of child/adult metabolic diseases.
Harrison Michael R. ; Heymann Michael A. ; Riemer Robert Kirk ; Natuzzi Eileen Stack, Method and agents for inducement of endogenous nitric oxide synthase for control and management of labor during pregnanc.
March Keith L. (Carmel IN) Hathaway David R. (Indianapolis IN) Wilensky Robert L. (Indianapolis IN), Method for delivery of smooth muscle cell inhibitors.
Kilbourn Robert G. (Houston TX) Griffith Owen W. (Milwaukee WI) Gross Steven S. (New York NY), Methods and compositions for the treatment of hypotension with arginine free essential and essential amino acids and arg.
Anderson Pamela A. (Washington Court House OH) Cipollo Kent L. (Westerville OH) Mohacsi Tivadar G. (Columbus OH), Nutritional formulation for the treatment of renal disease.
Henningfield Mary F. (Columbus OH) McEwen John W. (Hilliard OH) Miller Robert H. (Worthington OH), Nutritional product for trauma and surgery patients.
Cotter Richard (Libertyville IL) Johnson Robert C. (Westchester IL) Ward Michael (McHenry IL) Madsen David C. (Libertyville IL) Valicenti Anthony J. (Deerfield IL) Menard Michael P. (Grayslake IL) Tu, Nutritional support or therapy for individuals at risk or under treatment for atherosclerotic vascular, cardiovascular,.
Rath Matthias W. (Eberhardstrasse 12 7141 Kirchberg/Murr CA DEX) Pauling Linus C. (15 Salmon Creek Big Sur CA 93920), Prevention and treatment of occlusive cardiovascular disease with ascorbate and substances that inhibit the binding of l.
Wullschleger Richard D. (Battle Creek MI) Chen Shirley C. (Tokyo MI JPX) Bowman Frederick A. (Augusta MI) Hawblitz Larry V. (Battle Creek MI), Ready-to-eat-cereal containing psyllium and use thereof for lowering cholesterol levels.
Budzynski Andrei Z. (Glenside PA) Knight Linda C. (East Windsor NJ) Hasan Ahmed A. (Glenside PA), Thrombus-targeted complexes of plasminogen activator and fibrin fragments.
Garfield Robert E. ; Chwalisz Krzysztof,DEX ; Bukowski Radoslaw,DEX ; Yallamp'al Li Chandra, Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substra.
Cooke John P. (Palo Alto CA) Dzau Victor J. (Los Altos Hills CA) Gibbons Gary H. (Palo Alto CA), Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production of activity.
Cooke John P. ; Dzau Victor J. ; Gibbons Gary H., Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production or activity.
Levere Richard D. (5 Seymour Pl. W. Armonk NY 10504) Abraham Nader G. (143 Charter Cir. Ossining NY 10562) Schwartzman Michel L. (415 Old Country Rd. Elmsford NY 10523) Martasek Pavel (60 Hillcrest R, Use of L-arginine in the treatment of hypertension and other vascular disorders.
Yoshimura Norman N. (Westminster CA) Barbul Adrian (Baltimore MD) Tao Robert C. (Huntington Beach CA) Storm Michael C. (Laguna Niguel CA) Kelley Robert E. (Orange CA) Reis Brenda L. (Costa Mesa CA), Use of arginine as an immunostimulator.
Summar, Marshall L.; Barr, Frederick E.; Thompson, Reid Carleton, Methods and compositions for treatment for coronary and arterial aneurysmal subarachnoid hemorrhage.
Schoenfisch, Mark; Riccio, Daniel; Nugent, Julia; Stasko, Nathan, Nitric oxide-releasing S-nitrosothiol-modified silica particles and methods of making the same.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.